Tibesaikosaponin V (TKV) is a triterpene diglycoside, which can be isolated from the methanol extract of the roots of Bupleurum chinense DC. . Tibesaikosaponin V inhibits lipid accumulation and triacylglycerol content occurred without cytotoxicity to adipocytes. Tibesaikosaponin V suppresses the mRNA expression of nuclear transcription factors, such as peroxisome proliferator-activated receptor γ ( PPARγ ) and CCAAT/enhancer binding protein α ( C/EBPα ). Tibesaikosaponin V inhibits 3T3-L1 preadipocyte differentiation. Tibesaikosaponin V can be used fro research of obesity and its associated metabolic disorders
IC50& Target:PPARγ
规格
别名
西藏柴胡皂苷V
英文名称
Tibesaikosaponin V
生化机理
Tibesaikosaponin V(TKV)是一种三萜类二糖苷,可从柴胡根部的甲醇提取物中分离出来。.Tibesaikosaponin V 可抑制脂质积累和三酰甘油含量,对脂肪无细胞毒性。