计算溶液所需的质量、体积或浓度。
THK5351, 诊断
有货
为什么选择此级别
Moligand™ 级 ，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
THK5351 can be radiolabeled and used as a radiotracer for in vivo imaging of tau pathology in the brain.
In Vitro
Aggregated tau protein is a major neuropathological substrate central to the pathophysiology of neurodegenerative diseases such as Alzheimer's disease (AD). 18 F-THK5351 binds to Alzheimer disease hippocampal homogenates with high affinity (K d =2.9 nM; maximum number of binding sites=368.3 pmol/g tissue). It has fast dissociation from white-matter tissue. The THK5351 binding amount correlates with the amount of tau deposits in tissue. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
THK5351 exhibits favorable pharmacokinetics and no defluorination in mice. 18 F-THK5351 enters the brain immediately after intravenous injection and shows a fast washout from the brain. At 0.1 and 1 mg/kg, no animals died and no treatment-related changes in any animal are noted in clinical observations, body weight measurement, and pathologic examination . Autoradiography in the brain sections of patients with PSP demonstrates [ 3 H]THK-5351 binding to tau deposits with a high selectivity. Although patients with PSP exhibits no remarkable [ 18 F]THK-5351 retention in the temporal cortex, significantly higher tracer retention is observed in the globus pallidus and midbrain. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
规格
规格或纯度
Moligand™,10mM in DMSO
英文名称
THK5351
生化机理
THK5351 可进行放射性标记并用作放射性示踪剂，用于脑内 tau 病理学的活体成像。
储存条件
-80℃储存
运输条件
特低温运输
作用机制
诊断
名称和识别符
分子类型
小分子
Isomeric SMILES
CNC1=NC=C(C=C1)C2=NC3=C(C=C2)C=C(C=C3)OC[C@@H](CF)O
关联CAS
PubChem CID
MeSH Entry Terms
18F-THK5351;THK5351
分子量
327.35
技术文档
高级数据
产品属性
| ALogP | 2.8 |
|---|
安全和危险性（GHS）
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
Copyright © 2023至今 上海阿拉丁生化科技股份有限公司 保留所有权利。
危险品化学品经营许可证（带存储）