计算溶液所需的质量、体积或浓度。
概述
TMX-4100 is a selective phosphodiesterase 6D ( PDE6D ) degrader. TMX-4100 shows a high degradation preference for PDE6D with the DC 50 values less than 200 nM in MOLT4, Jurkat, and MM.1S cells. TMX-4100 can be used for the research of multiple myeloma
In Vitro
TMX-4100 (compound 3; 1 μM; 4 h) shows a high degradation preference for PDE6D in MOLT4 cells. TMX-4100 has better proteome-wide degradation selectivity in MOLT4 cells, compare to PDE6D degrader FPFT-2216. TMX-4100 does not impede the growth of KRAS-dependent cell lines (MIA PaCa-2, NCI-H358, AGS, PA-TU-8988T cells). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: MOLT4 cells Concentration: 1 μM Incubation Time: 4 hours Result: Showed a high degradation preference for PDE6D. Western Blot AnalysisCell Line: MOLT4, Jurkat, and MM.1S cells Concentration: 0 nM, 40 nM, 200 nM, 1 μM; Incubation Time: 4 hours Result: Showed a high degradation preference for PDE6D with the DC 50 value less than 200 nM.
IC50& Target:PDE6 PDE6D
规格
规格或纯度
10mM in DMSO
英文名称
TMX-4100
生化机理
TMX-4100 是一种选择性磷酸二酯酶 6D （PDE6D ）降解剂。TMX-4100 对 PDE6D 有很高的降解偏好，在 MOLT4、Jurkat 和 MM.1S 细胞中的 DC 50 值小于 200 nM。TMX-4100 可用于多发性骨髓瘤的研究。
储存条件
-80℃储存
运输条件
特低温运输
名称和识别符
分子类型
小分子
分子量
262.29
高级数据
质检证书(CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
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溶液计算器
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