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在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
TPC2-A1-P is a powerful and membrane permeable agonist of two pore channel 2 (TPC2) with an EC 50 of 10.5 μM. TPC2-A1-P plays its role by mimicking the physiological actions of PI(3,5)P2. TPC2-A1-P also shows higher potency to induce Na 2+ mobilisation fr
IC50& Target:EC50: 10.5 μM (TPC2)
In Vitro:Two-pore channels (TPC1-3) are ancient members of the voltage-gated ion channel superfamily. TPCs are expressed throughout the endo-lysosomal system and regulates the trafficking of various cargoes. TPC2 can mediate different physiological and possib
Biological Activity:TPC2-A1-P is a powerful and membrane permeable agonist of two porexa0channelxa02xa0(TPC2) with an EC 50 of 10.5 μM. TPC2-A1-P plays its role by mimicking the physiological actionsxa0ofxa0PI(3,5)P2. TPC2-A1-P also shows higher potency to induce Na 2+ mobil