咔唑类

AMMTC

技术标识符

IUPAC名称

N-[(6-methoxy-9-methyl-2,3,4,9-tetrahydro-1H-carbazol-4-yl)methyl]acetamide

SMILES

COc1ccc2c(c1)c1C(CCCc1n2C)CNC(=O)C

InChIKey

CYOQJCSHEFAKNY-UHFFFAOYSA-N

InChI

1S/C17H22N2O2/c1-11(20)18-10-12-5-4-6-16-17(12)14-9-13(21-3)7-8-15(14)19(16)2/h7-9,12H,4-6,10H2,1-3H3,(H,18,20)

8-[4-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]acetyl]piperazin-1-yl]-9-ethyl-6,6-dimethyl-11-oxo-5H-benzo[b]carbazole-3-carbonitrile

技术标识符

IUPAC名称

8-[4-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]acetyl]piperazin-1-yl]-9-ethyl-6,6-dimethyl-11-oxo-5H-benzo[b]carbazole-3-carbonitrile

SMILES

N#Cc1ccc2c(c1)[nH]c1c2C(=O)c2c(C1(C)C)cc(c(c2)CC)N1CCN(CC1)C(=O)CNc1cccc2c1C(=O)N(C2=O)C1CCC(=O)NC1=O

InChIKey

UMEMOEKJTJMMJN-UHFFFAOYSA-N

InChI

1S/C40H37N7O6/c1-4-22-17-25-26(40(2,3)36-34(35(25)50)23-9-8-21(19-41)16-28(23)43-36)18-30(22)45-12-14-46(15-13-45)32(49)20-42-27-7-5-6-24-33(27)39(53)47(38(24)52)29-10-11-31(48)44-37(29)51/h5-9,16-18,显示更多

关联靶标

ALK tyrosine kinase receptor

4-(9-ethyl-9H-carbazol-3-yl)-1-phosphonatobutane-1-sulfonate

技术标识符

IUPAC名称

4-(9-ethyl-9H-carbazol-3-yl)-1-phosphonatobutane-1-sulfonate

SMILES

CCn1c2ccc(cc2c2c1cccc2)CCCC(S(=O)(=O)[O-])P(=O)([O-])[O-]

InChIKey

ZZMVEURNXXVJQQ-UHFFFAOYSA-K

InChI

1S/C18H22NO6PS/c1-2-19-16-8-4-3-7-14(16)15-12-13(10-11-17(15)19)6-5-9-18(26(20,21)22)27(23,24)25/h3-4,7-8,10-12,18H,2,5-6,9H2,1H3,(H2,20,21,22)(H,23,24,25)/p-3

关联靶标

Squalene synthase

2‐Methyl‐11‐(1‐methylethyl)‐8‐(pyrimidin‐2‐yloxy)‐2,5,6,11,12,13‐hexahydro‐4H‐indazolo[5,4‐a]pyrrolo[3,4‐c]carbazol‐4‐one

技术标识符

IUPAC名称

2‐Methyl‐11‐(1‐methylethyl)‐8‐(pyrimidin‐2‐yloxy)‐2,5,6,11,12,13‐hexahydro‐4H‐indazolo[5,4‐a]pyrrolo[3,4‐c]carbazol‐4‐one

SMILES

Cn1nc2c(c1)c1c3C(=O)NCc3c3c(c1CC2)n(C(C)C)c1c3cc(cc1)Oc1ncccn1

InChIKey

GCRBQBQLMPBGQC-UHFFFAOYSA-N

InChI

1S/C27H24N6O2/c1-14(2)33-21-8-5-15(35-27-28-9-4-10-29-27)11-17(21)23-18-12-30-26(34)24(18)22-16(25(23)33)6-7-20-19(22)13-32(3)31-20/h4-5,8-11,13-14H,6-7,12H2,1-3H3,(H,30,34)

关联靶标

Protein delta homolog 1, Mitogen-activated protein kinase kinase kinase 12

1-allyl-2-[3-(isopropylamino)propoxy]-9H-carbazole

技术标识符

IUPAC名称

(3-{[1-(prop-2-en-1-yl)-9H-carbazol-2-yl]oxy}propyl)(propan-2-yl)amine

SMILES

C=CCc1c(OCCCNC(C)C)ccc2c1[nH]c1c2cccc1

InChIKey

UQDMMPHZGIOABI-UHFFFAOYSA-N

InChI

1S/C21H26N2O/c1-4-8-18-20(24-14-7-13-22-15(2)3)12-11-17-16-9-5-6-10-19(16)23-21(17)18/h4-6,9-12,15,22-23H,1,7-8,13-14H2,2-3H3

关联靶标

Squalene synthase

(S)-flurocarazolol

技术标识符

IUPAC名称

(2S)-1-(9H-carbazol-4-yloxy)-3-(1-fluoropropan-2-ylamino)propan-2-ol

SMILES

FCC(NC[C@@H](COc1cccc2c1c1ccccc1[nH]2)O)C

InChIKey

QHLGXPUIUKSADT-ABLWVSNPSA-N

InChI

1S/C18H21FN2O2/c1-12(9-19)20-10-13(22)11-23-17-8-4-7-16-18(17)14-5-2-3-6-15(14)21-16/h2-8,12-13,20-22H,9-11H2,1H3/t12?,13-/m0/s1

关联靶标

5-hydroxytryptamine receptor 1B, 5-hydroxytryptamine receptor 1A

pegcantratinib

技术标识符

IUPAC名称

3-[2-(2-methoxyethoxy)ethyl]-15'-methylspiro[1,3-oxazolidine-5,16'-28-oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8,10,12,20,22,24,26-nonaene]-2,3',4-trione

SMILES

CC12C3(CC(O1)N4C5=CC=CC=C5C6=C7C(=C8C9=CC=CC=C9N2C8=C64)CNC7=O)C(=O)N(C(=O)O3)CCOCCOC

InChIKey

MTDVEOMKVDOULD-UHFFFAOYSA-N

InChI

1S/C32H28N4O7/c1-31-32(29(38)34(30(39)43-32)11-12-41-14-13-40-2)15-22(42-31)35-20-9-5-3-7-17(20)24-25-19(16-33-28(25)37)23-18-8-4-6-10-21(18)36(31)27(23)26(24)35/h3-10,22H,11-16H2,1-2H3,(H,33,37)

cmp5

技术标识符

IUPAC名称

1-(9-ethylcarbazol-3-yl)-N-(pyridin-3-ylmethyl)methanamine

SMILES

CCn1c2ccc(cc2c2c1cccc2)CNCc1cccnc1

InChIKey

GAVUWQFIRGBDHN-UHFFFAOYSA-N

InChI

1S/C21H21N3/c1-2-24-20-8-4-3-7-18(20)19-12-16(9-10-21(19)24)13-23-15-17-6-5-11-22-14-17/h3-12,14,23H,2,13,15H2,1H3

关联靶标

Protein arginine N-methyltransferase 5

[³H]ramatroban

技术标识符

IUPAC名称

3-[(3R)-3-[(4-fluorophenyl)sulfonylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]propanoic acid

SMILES

OC(=O)CCn1c2CC[C@H](Cc2c2c1cccc2)NS(=O)(=O)c1ccc(cc1)F

InChIKey

LDXDSHIEDAPSSA-OAHLLOKOSA-N

InChI

1S/C21H21FN2O4S/c22-14-5-8-16(9-6-14)29(27,28)23-15-7-10-20-18(13-15)17-3-1-2-4-19(17)24(20)12-11-21(25)26/h1-6,8-9,15,23H,7,10-13H2,(H,25,26)/t15-/m1/s1

关联靶标

Prostaglandin D2 receptor 2, Thromboxane A2 receptor

TM30089

技术标识符

IUPAC名称

2-[3-[(4-fluorophenyl)sulfonyl-methylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid

SMILES

CN(C1CCC2=C(C1)C3=CC=CC=C3N2CC(=O)O)S(=O)(=O)C4=CC=C(C=C4)F

InChIKey

CANCTKXGRVNXFP-UHFFFAOYSA-N

InChI

1S/C21H21FN2O4S/c1-23(29(27,28)16-9-6-14(22)7-10-16)15-8-11-20-18(12-15)17-4-2-3-5-19(17)24(20)13-21(25)26/h2-7,9-10,15H,8,11-13H2,1H3,(H,25,26)

关联靶标

Prostaglandin D2 receptor 2

TTT-3002

技术标识符

SMILES

CNC(=O)[C@@]1(N)C[C@@H]2O[C@@]1(C)n1c3ccccc3c3c1c1n2c2ccccc2c1c1c3CNC1=O

InChIKey

DCAYZGCTSXLIHO-FYCNXDEQSA-N

InChI

1S/C27H23N5O3/c1-26-27(28,25(34)29-2)11-18(35-26)31-16-9-5-3-7-13(16)20-21-15(12-30-24(21)33)19-14-8-4-6-10-17(14)32(26)23(19)22(20)31/h3-10,18H,11-12,28H2,1-2H3,(H,29,34)(H,30,33)/t18-,26+,27-/m0/s1

关联靶标

Receptor-type tyrosine-protein kinase FLT3, Leucine-rich repeat serine/threonine-protein kinase 2

KL044

技术标识符

IUPAC名称

2-(9H-carbazol-9-yl)-N-(2-chloro-6-cyanophenyl)acetamide

SMILES

N#Cc1cccc(c1NC(=O)Cn1c2ccccc2c2c1cccc2)Cl

InChIKey

ZDAKKNHUWVTCRS-UHFFFAOYSA-N

InChI

1S/C21H14ClN3O/c22-17-9-5-6-14(12-23)21(17)24-20(26)13-25-18-10-3-1-7-15(18)16-8-2-4-11-19(16)25/h1-11H,13H2,(H,24,26)

关联靶标

Cryptochrome-1