UH-NIP-16 exhibits antimicrobial activity against Mycobacterium tuberculosis , with MIC 50 of 1.86 and 3.05 μM, for pathogenic mycobacterial strains H37Rv and CDC1551. UH-NIP-16 synergizes with Streptomycin , Isoniazid , Ethambutol and Bedaquiline , potentiates their anti-tuberculosis activities.