URB694 is a carbamate FAAH inhibitor that irreversibly carbamoylate the nucleophile catalytic serine in FAAH active site. URB694 exhibits antidepressant-like activity and cardioprotective effects. URB694 can be used to prepare 11 C-Carbonyl-URB694 for in vivo positron emission tomography (PET) imaging studies of the brain FAAH.