计算溶液所需的质量、体积或浓度。
为什么选择此级别
，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
UNC569 is a potent, reversible, ATP-competitive and orally active Mer kinase inhibitor with an IC 50 of 2.9 nM and a K i of 4.3 nM. UNC569 also inhibits Axl and Tyro3 with IC 50 s of 37 nM and 48 nM, respectively. UNC569 can be used for acute lymphoblastic leukemia (ALL) and atypical teratoid/rhabdoid tumors research
In Vitro
UNC569 (24 hours) induces apoptosis in ALL cell lines, and increases the levels of cleaved Caspase 3 and cleaved PARP. UNC569 (1 µM; 1.5 hours) treatment effectively inhibit the activation of Mer and downstream signaling, including the PI3K/AKT and MAPK/ERK pathways. UNC569 (1 hour) inhibits Mer phosphorylation levels with IC50 values of 141 nM and 193 nM in human B-ALL (acute lymphoblastic leukemia) 697 and Jurkat cell lines, respectively . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Apoptosis AnalysisCell Line: 697 and Jurkat cells Concentration: 0.4 µM, 0.8 µM, 1 µM, 1.2 µM, 1.4 µM, 1.6 µM, 1.8 µM, 2 µM Incubation Time: 24 hours Result: Induced apoptosis in ALL cell lines. Western Blot AnalysisCell Line: 697 and Jurkat cells Concentration: 1 µM Incubation Time: 1.5 hours Result: Inhibited Mer activation and downstream signaling through ERK1/2 and AKT.
In Vivo
The in vivo pharmacokinetic properties of UNC569 (3 mg/kg) are also assessed in mice via both intravenous (IV) and oral (PO) administration. UNC569 has low systemic clearance (19.5 mL/min/kg), high volume of distribution (V ss of 5.83 L/kg), and good oral bioavailability (57%) . Leukemic zebrafish are treated continuously for 2 weeks by immersion in 4 µM UNC569. the result shows that UNC569 induces more than 50% reduction in tumor burden compared with vehicle- and mock-treated fish. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
IC50& Target:IC50: 2.9 nM (Mer), 37 nM (Axl), 48 nM (Tyro3), Ki: 4.3 nM (Mer)
规格
规格或纯度
10mM in DMSO
英文名称
UNC569
生化机理
UNC569 是一种强效、可逆、具有 ATP 竞争性和口服活性的 Mer 激酶抑制剂，其 IC 50 为 2.9 nM，K i 为 4.3 nM。UNC569 还能抑制 Axl 和 Tyro3，其 IC 50 s 分别为 37 nM 和 48 nM。UNC569 可用于急性淋巴母细胞白血病的治疗。
储存条件
-80℃储存
运输条件
特低温运输
名称和识别符
分子类型
小分子
Isomeric SMILES
CCCCNC1=NC=C2C(=NN(C2=N1)CC3CCC(CC3)N)C4=CC=C(C=C4)F
PubChem CID
MeSH Entry Terms
UNC569
分子量
396.50
技术文档
高级数据
质检证书(CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
常见问题
本产品应如何储存？
请于?80 °C条件下保存。需超低温保存以维持规定的有效期。
本产品如何运输？
本产品采用干冰配冷袋冷冻运输。收货后请立即拆包，并按上述储存条件保存；处理干冰时请戴隔热手套并保持通风。
本产品的 CAS 号、分子式和分子量是多少？
本产品的 CAS 号为 1350547-65-7，分子式为 C22H29FN6，分子量为 396.50 g/mol。
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