VEGFR-2-IN-36 (compound 15) is a VEGFR-2 inhibitor ( IC 50 : 0.067 μM) and inducer of apoptosis with anticancer activity. VEGFR-2-IN-36 upregulates BAX levels and downregulates Bcl-2 levels. VEGFR-2-IN-36 is toxic to cancer cells, MCF-7 ( IC 50 =0.42 μM) and HepG2 ( IC 50 =0.22 μM).