Verosudil hydrochloride (AR-12286 hydrochloride) is the hydrochloride form of Verosudil. Verosudil hydrochloride is an inhibitor for Rho-kinase ( ROCK ) with K i s of 2 and 2 nM for ROCK1 and ROCK2 , respectively. Verosudil hydrochloride lowers intraocular pressure (IOP) primarily by increasing aqueous humour outflow through the trabecular meshwork.