VU6024578 (BI02982816) is a selective, orally active positive allosteric modulator (PAM) for metabotropic glutamate receptor ( mGluR1 ), that activates human mGluR1 and rat mGluR1 with EC 50 of 54 nM and 46 nM. VU6024578 exhibits antipsychotic activity in rats amphetamine-induced hyperactivity models and MK-801 -induced novel object recognition (NOR) models. VU6024578 is blood brain barrier penetrable.