VH032 -C2-NH-Boc is a Boc-modified VH032 that acts as a ligand for VHL and recruits von Hippel-Lindau (VHL) proteins. VH032 -C2-NH-Boc will remove the protecting group under acidic conditions, and can be directly used for the synthesis of PROTAC molecules. VH032 -C2-NH-Boc is a key intermediate for the synthesis of PROTACs based on VHL ligands.