VHL Ligand-Linker Conjugates 17 incorporates a VHL ligand for the E3 ubiquitin ligase , and a PROTAC linker. VHL Ligand-Linker Conjugates 17 can be used in the synthesis of a series of PROTACs , such as ARD-266. ARD-266 is a highly potent androgen receptor (AR) PROTAC degrader. VHL Ligand-Linker Conjugates 17 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.