计算溶液所需的质量、体积或浓度。
为什么选择此级别
，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
VU041 is a first submicromolar-affinity inhibitor of Anopheles (An.) gambiae and Aedes (Ae.) aegypti inward rectifier potassium 1 (Kir1) channels with IC 50 values of 2.5 μM and 1.7 μM, respectively. VU041 inhibits appreciably is mammalian Kir2.1 ( IC 50 of 12.7 μM), and has less inhibitory effect on mammalian Kir1.1, Kir4.1, Kir6.2/SUR1, and Kir7.1. VU041 also induces impaired Malpighian tubule function
In Vitro
VU041 is only moderately metabolized by cytochrome P450 enzymes and does not appear to be metabolized by esterases. VU041 is the first small-molecule inhibitor of mosquito Kir1 channels that exhibits topical toxicity in both insecticide-susceptible and -resistant lines of mosquitoes. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Topical VU041 application to adult female mosquitoes of both species inhibits their fecundity. Importantly, VU041 is selective for mosquito Kir channels over mammalian Kir channel orthologs and non-lethal to adult honey bees (Apis mellifera). The in vivo experiments of blood meal processing and diuretic capacity suggest that one mechanism of action of VU041 is the disruption of excretory functions mediated by Malpighian tubules . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
IC50& Target:IC50: 2.5 μM ( Anopheles (An.) gambiae Kir1 channels), 1.7 μM ( Aedes (Ae.) aegypti Kir1 channels) and 12.7 μM (Mammalian Kir2.1)
规格
规格或纯度
10mM in DMSO
英文名称
VU041
生化机理
VU041 是冈比亚按蚊（An. gambiae）和埃及伊蚊（Aeedes. aegypti）内向整流钾 1（Kir1）通道的首个亚摩尔亲和性抑制剂，其 IC 50 值分别为 2.5u2009μM 和 1.7u2009μM。VU041 对哺乳动物 Kir2.1 有明显的抑制作用。
储存条件
-80℃储存
运输条件
特低温运输
名称和识别符
分子类型
小分子
Isomeric SMILES
C1CCC2=C(C1)C(=NN2CC(=O)N3CCCC4=CC=CC=C43)C(F)(F)F
PubChem CID
分子量
363.38
技术文档
高级数据
质检证书（CoA,COO,BSE/TSE 和分析图谱)
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溶液计算器
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