WD6305 is a potent and selective METTL3-METTL14 PROTAC degrader. WD6305 has DC 50 values of 140 nM and 194 nM for METTL3 and METTL14 , respectively. WD6305 inhibits m 6 A modification and proliferation of AML cells, and induces apoptosis. WD6305 has antitumor activity.(Pink: UZH2 ; Black: Linker; Blue: VHL ligand )