Wulfenioidin F is a diterpenoid, that can be isolated from the whole plant of Orthosiphon wulfenioides. Wulfenioidin F exhibits activity against Zika virus (ZIKV) with an EC 50 of 8.07 μM. Wulfenioidin F interferes with the replication of the ZIKV by inhibiting the expression of the ZIKV envelope (E) protein.