WYRGRL 是一种选择性的、高亲和力的胶原 II 型 (collagen type II) 亲和肽,其 IC50 为 140 nM。II 型胶原是关节软骨细胞外基质中最主要、最特异的结构蛋白。WYRGRL 可将小分子化合物如 Dexamethasone (D137736) 和纳米载体工程化外泌体精准导向软骨,显著增强了其治疗骨关节炎的效果。
氨基酸序列(Sequence): Trp-Tyr-Arg-Gly-Arg-Leu
WYRGRL is a selective, high-affinity collagen type II-binding peptide with a IC50 of 140 nM. Collagen type II is the most abundant and specific structural protein in the extracellular matrix of articular cartilage. WYRGRL can precisely target small-molecule compounds such as Dexamethasone (D137736) and nanocarrier-engineered exosomes to cartilage, significantly enhancing their therapeutic effects on osteoarthritis
Sequence: Trp-Tyr-Arg-Gly-Arg-Leu