XM462 is a dihydroceramide desaturase inhibitor. XM462 produced a mixed-type inhibition (K i =2 μM) in vitro. XM462 has dihydroceramide desaturase inhibition both in vitro and in cultured cells with IC 50 values of 8.2 and 0.78 μM, respectively. XM462 can be used for the research of tumor.