YLT-11 is a potent, selective and orally active PLK4 inhibitor with K d values of >10000, 653, >10000, 5.2 nM for PLK1 , PLK2 , PLK3 , PLK4 , respectively. YLT-11 shows antiproliferative activity. YLT-11 induces Apoptosis and cell cycle arrest at G2/M phase. YLT-11 show anticancer activity.