计算溶液所需的质量、体积或浓度。
为什么选择此级别
，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
YC-001 is an inverse agonist and antagonist of rod opsin . YC-001 reversibly binds rod opsin and stabilizes the rod opsin structure. YC-001 protects mice from bright light-induced retinal degeneration. YC-001 has the potential for the research of retinal degeneration
In Vitro
YC-001 (0-100 µM) shows a potency activity of 8.7 µM and an efficacy at 150–310%. YC-001 (0.5, 1, 5, 10, 20, 40 µM) improves the glycosylation profile of P23H opsin mutant. YC-001 (0,-1.5 µM) reversibly binds rod opsin with EC 50 OF 0.98 µM. YC-001 (0.313, 0.625, 1.25, 2.5, 5, 10, 20, 80 µM) increases in cAMP level in a dose-dependent manner in NIH3T3 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: NIH3T3 cells Concentration: 0.5, 1, 5, 10, 20, 40 µM Incubation Time: Result: Improved the glycosylation profile of P23H opsin.
In Vivo
YC-001 (50, 200mg/kg; i.p.) protects Abca4−/−Rdh8−/− mice from bright light-induced retinal degeneration . YC-001 (200mg/kg; i.p.) enters mouse eyes after systemic administration but is not retained for prolonged periods . YC-001 (100 mg/kg, 200 mg/kg; i.p.; daily for 24 days) shows virtually no acute toxicity . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 6-week-old Abca4 −/−Rdh8−/− mice Dosage: 50, 200mg/kg Administration: I.P. Result: Protected Abca4−/−Rdh8−/− mice from bright light-induced retinal degeneration. Animal Model: C57BL/6 mouse Dosage: 200 mg/kg Administration: I.P. Result: Entered mouse eyes after systemic administration but is not retained for prolonged periods. Animal Model: C57BL/6 mice Dosage: 100 mg/kg, 200 mg/kg Administration: I.p.; daily, 24 days Result: Showed no acute toxicity.
IC50& Target:rod opsin
规格
规格或纯度
10mM in DMSO
英文名称
YC-001
生化机理
YC-001 是杆状视蛋白的反向激动剂和拮抗剂。YC-001 可逆地与杆状视蛋白结合，并稳定杆状视蛋白的结构。YC-001 可保护小鼠免受强光诱导的视网膜变性。YC-001 具有研究视网膜变性的潜力。
储存条件
-80℃储存
运输条件
特低温运输
名称和识别符
技术文档
高级数据
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
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溶液计算器
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