(Z)-Ganoderenic acid D is the z-isomer of Ganoderenic acid D. (Z)-Ganoderenic acid D is the triterpene that can be isolated from Ganoderma , and contributes to the bitter taste of the basidiocarps and extracts of Ganoderma species. Ganoderenic acid D inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis.