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,适用于对基线干扰要求严格的色谱和分析工作流程。
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在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
ZX782 is a Hty -type PROTAC targeting GPX4 and a ferroptosis inducer, which induces GPX4 degradation and significantly increases lipid ROS accumulation in HT1080 cells. ZX782 can be used to treat AD by reducing the size and/or number of brain amyloid plaques and by inhibiting the spread of IL-1beta-positive microglial-like cells around amyloid plaques. ZX782 is labeled with hydrophobic benzyl alcohol (HBA) and appears bright blue under acidic conditions, which can be used for quantitative determination. ZX782 is composed of target protein ligand (red part) ML-210 , PROTAC linker (black part) Bromo-PEG2-CH2-Boc and Hty molecule (blue part) Adamantan-1-ylmethanamine. The conjugate consisting of Hyt and linker parts is Adamantan-C-amide-PEG2-C-Br , and the activity control of the target protein ligand is Hydroxyl-ML-210.