KT-413 (example I-3) is an orally active PROTAC-class IRAK degrader. KT-413 consists of a target protein ligand (red part) PROTAC IRAK4 ligand-5 , an E3 ubiquitin ligase ligand (blue part) Thalidomide-4-Br , and a PROTAC linker (black part) 2-(2-Azaspiro[3.3]heptan-6-yl)ethanamine. E3 ubiquitin ligase and linker can form Thalidomide-NH-C2-2-azaspiro[3.3]heptane. The active control for the target protein ligand is RSL3-4-Me.