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N-乙酰-L-谷氨酰胺

规格或纯度: 99%
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货号 (SKU) 包装规格 是否现货 价格 数量
A117200-5g
 5g 现货 Stock Image
A117200-25g
 25g 现货 Stock Image
A117200-100g
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化学生物学 谷氨酰胺
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基本描述

别名 乙酰谷氨酰胺|Ac-Gln-OH
英文别名 Aceglutamide|N-Acetyl-L-glutamine|2490-97-3|N-Acetylglutamine|L-Glutamine, N2-acetyl-|L-Glutamine, N-acetyl-|N2-Acetyl-L-glutamine|Nalpha-Acetyl-L-glutamine|acetyl-l-glutamine|(S)-2-Acetamido-5-amino-5-oxopentanoic acid|Aceglutamid|Acetylglutamine|N2-acet
规格或纯度 99%
英文名称 N-Acetyl-L-Glutamine
应用 一种骨吸收抑制剂；金合欢基二磷酸合成酶抑制剂 （farnesyl diphosphate synthase）(IC50 = 460 nM); CD45蛋白酪氨酸磷酸酯酶(protein tyrosine phosphatase )抑制剂。
储存温度 2-8°C储存
运输条件 冰袋运输
产品介绍

易溶于水，能溶于乙醇和乙酸乙酯。 一种骨吸收抑制剂；金合欢基二磷酸合成酶抑制剂 （farnesyl diphosphate synthase）(IC50 = 460 nM); CD45蛋白酪氨酸磷酸酯酶(protein tyrosine phosphatase )抑制剂。

名称和标识符

EC号 219-647-7
IUPAC Name (2S)-2-acetamido-5-amino-5-oxopentanoic acid
INCHI InChI=1S/C7H12N2O4/c1-4(10)9-5(7(12)13)2-3-6(8)11/h5H,2-3H2,1H3,(H2,8,11)(H,9,10)(H,12,13)/t5-/m0/s1
InChi Key KSMRODHGGIIXDV-YFKPBYRVSA-N
Canonical SMILES CC(=O)NC(CCC(=O)N)C(=O)O
Isomeric SMILES CC(=O)N[C@@H](CCC(=O)N)C(=O)O
WGK Germany 3
PubChem CID 182230
分子量 188.18
Beilstein号 1727471
Reaxy-Rn 1727471

化学和物理性质

密度 1.29
比旋光度 -12 ° (C=3, H2O)
熔点 195-199°C

安全和危险性（GHS）

WGK Germany 3
Reaxy-Rn 1727471
Merck Index 25
个人防护装备 Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

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参考文献

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7. Satu Pekkala,Ana I Martínez,Belén Barcelona,Igor Yefimenko,Ulrich Finckh,Vicente Rubio,Javier Cervera.  (2010-06-26)  Understanding carbamoyl-phosphate synthetase I (CPS1) deficiency by using expression studies and structure-based analysis..  Human mutation,  31  ((7)):  (801-808).  [PMID:20578160]
8. Hannah C Bygd,Lilusi Ma,Kaitlin M Bratlie.  (2017-06-21)  Physicochemical properties of liposomal modifiers that shift macrophage phenotype..  Materials science & engineering. C, Materials for biological applications,  79  ():  (237-244).  [PMID:28629014]
9. Cecilia Roux,Chiara Riganti,Sammy Ferri Borgogno,Roberta Curto,Claudia Curcio,Valeria Catanzaro,Giuseppe Digilio,Sergio Padovan,Maria Paola Puccinelli,Monica Isabello,Silvio Aime,Paola Cappello,Francesco Novelli.  (2017-12-10)  Endogenous glutamine decrease is associated with pancreatic cancer progression..  Oncotarget,  8  ((56)):  (95361-95376).  [PMID:29221133]
10. Ninghua Huang,Bing Cao,Elisa Brietzke,Caroline Park,Danielle Cha,Zihang Pan,Judy Zhu,Yaqiong Liu,Qing Xie,Jing Zeng,Roger S McIntyre,Jingyu Wang,Lailai Yan.  (2018-12-24)  A pilot case-control study on the association between N-acetyl derivatives in serum and first-episode schizophrenia..  Psychiatry research,  272  ():  (36-41).  [PMID:30579179]
11. Yukako Komaki,Adam M-A Simpson,Jong Kwon Choe,Margaux M Pinney,Daniel Herschlag,Yi-Hsueh Chuang,William A Mitch.  (2019-07-28)  Serum electrolytes can promote hydroxyl radical-initiated biomolecular damage from inflammation..  Free radical biology & medicine,  141  ():  (475-482).  [PMID:31349038]
12. Y Chen.  (1992-01-01)  Clinical research on treating senile dementia by combining acupuncture with acupoint-injection..  Acupuncture & electro-therapeutics research,  17  ((2)):  (61-73).  [PMID:1353652]
13. D Barrett,N A Breslau,M B Wax,P B Molinoff,R W Downs.  (1989-08-11)  New form of pseudohypoparathyroidism with abnormal catalytic adenylate cyclase..  The American journal of physiology,  257  ((2 Pt 1)):  (E277-E283).  [PMID:2548394]
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