计算溶液所需的质量、体积或浓度。
| 活性类型 | 活性值-log(M) | 作用机制 | 期刊 | 参考文献(PubMed IDs) |
|---|
有货
为什么选择此级别
Moligand™ 级 提供 ≥97% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
避光,室温,充氩。常规运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 29 篇同行评审文献引用。
规格
别名
乙酰胆碱
英文别名
ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl | ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl- | KBio1_000686 | C01996 | EINECS 200-128-9 | Epitope ID:176773 | OIPILFWXSMYKGL-UHFFFAOYSA-N | 2rin | BDBM10759 | KBio3_001292 | NCGC00018123-02 | AB00053790-25 | N
规格或纯度
Moligand™, ≥97%
英文名称
Acetylcholine
储存条件
避光,室温,充氩
运输条件
常规运输
作用类型
激动剂
作用机制
M 1 受体激动剂；M 2 受体激动剂；M 3 受体激动剂；M 4 受体激动剂；M 5 受体激动剂
纯度
≥97%
名称和识别符
EC号
200-128-9
分子类型
小分子
IUPAC Name
2-acetyloxyethyl(trimethyl)azanium
INCHI
1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1
InChi Key
OIPILFWXSMYKGL-UHFFFAOYSA-N
Smiles
CC(=O)OCC[N+](C)(C)C
Isomeric SMILES
CC(=O)OCC[N+](C)(C)C
PubChem CID
MeSH Entry Terms
2-(Acetyloxy)-N,N,N-trimethylethanaminium;Acetilcolina Cusi;Acetylcholine;Acetylcholine Bromide;Acetylcholine Chloride;Acetylcholine Fluoride;Acetylcholine Hydroxide;Acetylcholine Iodide;Acetylcholine L Tartrate;Acetylcholine L-Tartrate;Acetylcholine Perc
分子量
146.21
技术文档
高级数据
系统学分类
分类树（Taxonomy Tree）
| 界（kingdom) | 有机化合物 |
|---|---|
| 超类（Superclass) | 有机氮化合物 |
| 类（Class) | 有机氮化合物 |
| 亚类（Subclass） | 季铵盐 |
| 中间层级节点（Intermediate Tree Nodes） | 胆碱 |
| 直接上位类(Direct Parent) | 酰基胆碱 |
| 其他上位类（Alternative Parents） | 四烷基铵盐 羧酸酯 一元羧酸及其衍生物 有机光子化合物 有机盐 有机氧化物 碳氢化合物衍生物 羰基化合物 胺类 有机阳离子 |
| 分子骨架（Molecular Framework) | 脂肪族无环化合物 |
| 取代基（Substituents） | 酰基胆碱 - 脂肪族非环化合物 - 氨基酸 - 羰基 - 羧酸衍生物 - 羧酸酰胺 - 烃衍生物 - 单羧酸或其衍生物 - 有机铵盐 - 有机氧化物 - 有机氧化合物 - 有机盐 - 有机氧化合物 - 有机氮化合物 - 四烷基铵盐 |
| 描述（Description） | 该化合物属于有机化合物类别中的酰基胆碱类。此类化合物为胆碱的酰化衍生物。胆碱（2-羟基-N,N,N-三甲基乙酰胺）是一种季铵盐，化学式为(CH₃)₃N⁺(CH₂)₂OH。 |
| 外部描述符（External Descriptors） | a small molecule |
三维结构
交互式化学结构模型
关联靶点（人）
CHRNA7
Tchem
神经元乙酰胆碱受体亚基 α-7(Neuronal acetylcholine receptor subunit alpha-7)
(6 活性数据)
CHRM5
Tclin
毒蕈碱乙酰胆碱受体 M5(Muscarinic acetylcholine receptor M5)
(4 活性数据)
CHRM3
Tclin
毒蕈碱乙酰胆碱受体 M3(Muscarinic acetylcholine receptor M3)
(5 活性数据)
CHRM4
Tclin
毒蕈碱乙酰胆碱受体 M4(Muscarinic acetylcholine receptor M4)
(5 活性数据)
CHRM2
Tclin
毒蕈碱乙酰胆碱受体 M2(Muscarinic acetylcholine receptor M2)
(7 活性数据)
CHRM1
Tclin
毒蕈碱乙酰胆碱受体 M1(Muscarinic acetylcholine receptor M1)
(6 活性数据)
F2
Tclin
Thrombin
(11687 活性数据)
ESR1
Tclin
Estrogen receptor alpha
(17718 活性数据)
NR3C1
Tclin
Glucocorticoid receptor
(14987 活性数据)
PGR
Tclin
Progesterone receptor
(8562 活性数据)
ADRB2
Tclin
Beta-2 adrenergic receptor
(11824 活性数据)
CHRM2
Tclin
Muscarinic acetylcholine receptor M2
(10671 活性数据)
ADRB1
Tclin
Beta-1 adrenergic receptor
(6630 活性数据)
HTR1A
Tclin
Serotonin 1a (5-HT1a) receptor
(14969 活性数据)
ADRA2A
Tclin
Alpha-2a adrenergic receptor
(9450 活性数据)
AR
Tclin
Androgen Receptor
(11781 活性数据)
CHRM1
Tclin
Muscarinic acetylcholine receptor M1
(12690 活性数据)
DRD2
Tclin
Dopamine D2 receptor
(23596 活性数据)
GABRA1
Tclin
GABA receptor alpha-1 subunit
(399 活性数据)
MAOA
Tclin
Monoamine oxidase A
(11911 活性数据)
CNR1
Tclin
Cannabinoid CB1 receptor
(20913 活性数据)
DRD1
Tclin
Dopamine D1 receptor
(9720 活性数据)
DRD4
Tchem
Dopamine D4 receptor
(7907 活性数据)
ACHE
Tclin
Acetylcholinesterase
(18204 活性数据)
PTGS1
Tclin
Cyclooxygenase-1
(9233 活性数据)
SLC6A2
Tclin
Norepinephrine transporter
(10102 活性数据)
HRH2
Tclin
Histamine H2 receptor
(5428 活性数据)
HTR2A
Tclin
Serotonin 2a (5-HT2a) receptor
(14758 活性数据)
HTR2C
Tclin
Serotonin 2c (5-HT2c) receptor
(11471 活性数据)
AVPR2
Tclin
Vasopressin V2 receptor
(2912 活性数据)
ADORA1
Tclin
Adenosine A1 receptor
(17603 活性数据)
AGTR1
Tclin
Type-1 angiotensin II receptor
(5176 活性数据)
SLC6A4
Tclin
Serotonin transporter
(12625 活性数据)
CRHR1
Tclin
Corticotropin releasing factor receptor 1
(2996 活性数据)
ADRA1A
Tclin
Alpha-1a adrenergic receptor
(8359 活性数据)
PTGS2
Tclin
Cyclooxygenase-2
(13999 活性数据)
HRH1
Tclin
Histamine H1 receptor
(7573 活性数据)
OPRM1
Tclin
Mu opioid receptor
(19785 活性数据)
DRD3
Tclin
Dopamine D3 receptor
(14368 活性数据)
AVPR1A
Tclin
Vasopressin V1a receptor
(5412 活性数据)
OPRD1
Tclin
Delta opioid receptor
(15096 活性数据)
OPRK1
Tclin
Kappa opioid receptor
(16155 活性数据)
HTR3A
Tclin
Serotonin 3a (5-HT3a) receptor
(3366 活性数据)
GCGR
Tclin
Glucagon receptor
(2563 活性数据)
SLC6A3
Tclin
Dopamine transporter
(10535 活性数据)
GRIN1
Tclin
Glutamate (NMDA) receptor subunit zeta 1
(122 活性数据)
KCNH2
Tclin
HERG
(29587 活性数据)
CACNA1C
Tclin
Voltage-gated L-type calcium channel alpha-1C subunit
(766 活性数据)
PDE3A
Tclin
Phosphodiesterase 3A
(3309 活性数据)
ESR2
Tclin
Estrogen receptor beta
(9272 活性数据)
SLC29A1
Tclin
Equilibrative nucleoside transporter 1
(1711 活性数据)
CHRM4
Tclin
Muscarinic acetylcholine receptor M4
(6041 活性数据)
CHRM5
Tclin
Muscarinic acetylcholine receptor M5
(4677 活性数据)
ADRA2B
Tclin
Alpha-2b adrenergic receptor
(4412 活性数据)
ADRA2C
Tclin
Alpha-2c adrenergic receptor
(4876 活性数据)
CHRM3
Tclin
Muscarinic acetylcholine receptor M3
(7750 活性数据)
关联靶点（其它种属）
Mc4r
Melanocortin receptor 4 (1205 活性数据)
Npy1r
Neuropeptide Y receptor type 1 (8 活性数据)
Cckar
Cholecystokinin A receptor (90 活性数据)
Ntsr1
Neurotensin receptor 1 (48 活性数据)
Pde4d
Phosphodiesterase 4D (4 活性数据)
Bdkrb1
Bradykinin B1 receptor (77 活性数据)
Glra1
Glycine receptor subunit alpha-1 (65 活性数据)
Periplaneta americana (513 活性数据)
Oryctolagus cuniculus (11301 活性数据)
Mus musculus (284745 活性数据)
Rattus norvegicus (775804 活性数据)
RAW264.7 (28094 活性数据)
CHRNA4
Neuronal acetylcholine receptor subunit alpha-4 (14 活性数据)
rep
Replicase polyprotein 1ab (378 活性数据)
Acetylcholine-binding protein (240 活性数据)
Aorta (2975 活性数据)
Slc22a5
Solute carrier family 22 member 5 (44 活性数据)
Chrna3
Neuronal acetylcholine receptor; alpha3/beta2 (421 活性数据)
Chrna2
Neuronal acetylcholine receptor; alpha2/beta2 (198 活性数据)
Chrna3
Neuronal acetylcholine receptor; alpha3/beta4 (1368 活性数据)
Chrm1
Muscarinic acetylcholine receptor (3770 活性数据)
Chrna3
Neuronal acetylcholine receptor (756 活性数据)
Nicotinic acetylcholine receptor alpha8 subunit (79 活性数据)
SARS-CoV-2 (38078 活性数据)
作用机制
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
化学和物理性质
敏感性
对光和湿度敏感
分子量
146.210 g/mol
XLogP3
0.200
氢键供体数Hydrogen Bond Donor Count
0
氢键受体数Hydrogen Bond Acceptor Count
2
可旋转键计数Rotatable Bond Count
4
精确质量Exact Mass
146.118 Da
单同位素质量Monoisotopic Mass
146.118 Da
拓扑极表面积Topological Polar Surface Area
26.300 Ų
重原子数Heavy Atom Count
10
形式电荷Formal Charge
1
复杂度Complexity
115.000
同位素原子数Isotope Atom Count
0
定义的原子立体中心计数Defined Atom Stereocenter Count
0
未定义的原子立体中心计数Undefined Atom Stereocenter Count
0
定义的键立体中心计数Defined Bond Stereocenter Count
0
未定义的键立体中心计数Undefined Bond Stereocenter Count
0
所有立体化学键的总数The total count of all stereochemical bonds
0
共价键合单元计数Covalently-Bonded Unit Count
1
安全和危险性（GHS）
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
此产品的引用文献
引用文献
| 1. Zou Gang, Yu Ruihong, Zhao Dezhang, Duan Zhaohui, Guo Shimin, Wang Tingting, Ma Limei, Yuan Zhiyi, Yu Chao. (2023) Celastrol ameliorates energy metabolism dysfunction of hypertensive rats by dilating vessels to improve hemodynamics. Journal of Natural Medicines, [PMID:38032498] [10.1007/s11418-023-01759-x] |
| 2. Haifeng Yao, Yahui Zhang, Yongping Dong, Mingfu Ye. (2023) Inhibiting effect of graphdiyne on Ru(bpy)32+ ECL and its application in drug detection based on the host–guest interaction of cucurbit[8]uril. JOURNAL OF ELECTROANALYTICAL CHEMISTRY, [10.1016/j.jelechem.2023.117868] |
| 3. Wenting Lin, Kan Li, Yingjun Qin, Xing Han, Xiaohui Chen, Yuan Ren. (2023) Flunitrazepam induces neurotoxicity in zebrafish through microbiota-gut-brain axis. SCIENCE OF THE TOTAL ENVIRONMENT, [PMID:37532048] [10.1016/j.scitotenv.2023.165974] |
| 4. Puli Hu, Yaowei Zhou, Aori Qileng, Hongzhi Liang, Beier Kong, Weipeng Liu, Yingju Liu. (2023) The cohesion of cascade enzyme reaction with metal-organic framework composite for the sensitive detection of malathion and in-situ imaging of vegetables. SENSORS AND ACTUATORS B-CHEMICAL, [10.1016/j.snb.2023.133591] |
| 5. Xin Huang, Rui Wang, Yikai Wang, Changbao Chen, Shuying Liu. (2022) Investigation on property differences of ginseng and American ginseng by spatial metabolomics of neurochemicals with desorption electrospray ionization mass spectrometry imaging. JOURNAL OF ETHNOPHARMACOLOGY, [PMID:36516905] [10.1016/j.jep.2022.116006] |
| 6. Zixin Li, Luchen Shan, Pei Yu. (2022) Preventive effect of tetramethylpyrazine on nitroglycerin-tolerance in rats by improving oxidative stress and ribosome homeostasis. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, [PMID:35724458] [10.1016/j.bbrc.2022.06.013] |
| 7. Dong Guo, Lulu Luo, Yuan Kong, Zhiyang Kuang, Siyi Wen, Meirong Zhao, Weiguang Zhang, Jun Fan. (2022) Enantioselective neurotoxicity and oxidative stress effects of paclobutrazol in zebrafish (Danio rerio). PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, [PMID:35772839] [10.1016/j.pestbp.2022.105136] |
| 8. Wu Hongjiao, Chen Jiaqi, Yang Yi, Yu Weitai, Chen Ying, Lin Pengcheng, Liang Ke. (2022) Smartphone-coupled three-layered paper-based microfluidic chips demonstrating stereoscopic capillary-driven fluid transport towards colorimetric detection of pesticides. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 414 (5): (1759-1772). [PMID:35059790] [10.1007/s00216-021-03839-x] |
| 9. Dan Luo, Shao-zhong Hu, Ting Huang, Nan Zhang, Yan-zhou Lei, Yong Wang. (2021) Electrospun Cellulose Acetate/Polyethylenimine Porous Fibers toward Highly Efficient Removal of Cr(VI). ACS Applied Polymer Materials, [10.1021/acsapm.1c00836] |
| 10. Si Tang, Jing Zhu, Dong Zhao, Huaheng Mo, Zhaofu Zeng, Mengqing Xiong, Minglin Dong, Ke Hu. (2020) Effects of the excitation or inhibition of basal forebrain cholinergic neurons on cognitive ability in mice exposed to chronic intermittent hypoxia. BRAIN RESEARCH BULLETIN, [PMID:32905806] [10.1016/j.brainresbull.2020.08.027] |
| 11. Qi Wu, Yifei Wang, Linxia Wang, Yu Su, Guorong He, Xiaojiang Chen, Lei Hou, Wenyan Zhang, Yao-Yu Wang. (2024) A Portable Electrochemical Biosensor Based on an Amino-Modified Ionic Metal–Organic Framework for the One-Site Detection of Multiple Organophosphorus Pesticides. ACS Applied Materials & Interfaces, [PMID:39363450] [10.1021/acsami.4c13087] |
| 12. Yamin Liu, Xunjiang Wang, Jiaojiao Wei, Kangning Fu, Yilin Chen, Linnan Li, Zhengtao Wang, Li Yang. (2024) Comprehensive Profiling of Amino Acids and Derivatives in Biological Samples: A Robust UHPLC-MS/MS Method for Investigating Acute Lung Injury. JOURNAL OF CHROMATOGRAPHY A, [PMID:38537486] [10.1016/j.chroma.2024.464816] |
| 13. Hongxin Zhang, Xuegang Li, Xue Zhou, Fang Wang, Yanan Zhang, Yong Zhao. (2024) Dual-Channel Optical Fiber SPR Sensor: Sensitive Tributyrin Measurement From Trace to High Levels. IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT, [10.1109/TIM.2024.3427791] |
| 14. Chen Ruan, Siqi Zhou, Xinru Wu, Lina Zou, Rong Wang, Gaiping Li. (2024) Lanthanide coordination polymers as luminescent laccase mimics for ratiometric sensing of dopamine. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, [PMID:39520818] [10.1016/j.saa.2024.125398] |
| 15. Hongxin Zhang, Xuegang Li, Xue Zhou, Yanan Zhang, Yong Zhao. (2024) Optical Fiber Surface Plasmon Resonance Sensor for Glyceryl Tributyrate Detection Based on the PAA/CS Composite Hydrogel Embedding Protease Method. ANALYTICAL CHEMISTRY, [PMID:38656893] [10.1021/acs.analchem.3c05357] |
| 16. Hongxin Zhang, Xuegang Li, Xue Zhou, Yanan Zhang, Yong Zhao. (2024) Sensitive and Label-Free Optical Fiber Biosensor Based on ZIF-8/Lipase Composite Material and Its Application in Tributyrin Detection. IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT, [10.1109/TIM.2024.3379069] |
| 17. Guo Haihua, Li Meng, Lin Yue, Zhai Zizhao, Wang Guanlin, Zhao Suqing. (2024) The Prophylactic Effects of Isosteviol Aerosol Inhalation on Bronchial Asthma in Mice. PHARMACEUTICAL CHEMISTRY JOURNAL, 57 (12): (1872-1882). [10.1007/s11094-024-03091-4] |
| 18. Hao-Hua Deng, Hua-Ping Peng, Kai-Yuan Huang, Shao-Bin He, Qiao-Feng Yuan, Zhen Lin, Rui-Ting Chen, Xing-Hua Xia, Wei Chen. (2019) Self-Referenced Ratiometric Detection of Sulfatase Activity with Dual-Emissive Urease-Encapsulated Gold Nanoclusters. ACS Sensors, [PMID:30652857] [10.1021/acssensors.8b01130] |
| 19. Yuan Li, Yinying Ding, Jifeixue Zhao, Xiaogang Luo. (2025) Acetylcholinesterase-immobilized cellulose membrane biosensors designed by covalent bonding for indirect visual colorimetric detection of chlorpyrifos. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, [PMID:40096780] [10.1016/j.saa.2025.126005] |
| 20. Baoting Dou, Hui Shen, Zhimin Li, Huanyu Cheng, Po Wang. (2025) Chemically modified DNAzymes-based electrochemical sensor for binary and highly sensitive detection of reactive oxygen species. Chemical Science, [PMID:39867952] [10.1039/D4SC05512H] |
| 21. Hongxin Zhang, Xuegang Li, Xue Zhou, Yanan Zhang, Yong Zhao. (2024) Label-free SPR fiber microfluidic sensor with PDA-MA cross-linked lipase for specific detection of tributyrin. OPTICS AND LASER TECHNOLOGY, [10.1016/j.optlastec.2024.111054] |
| 22. Jie Yan, Xiaowen Zhang, Lifeng Feng, Shengzheng Zhang, Han Wei, Wencong Tian, Qiwen Li, Jing Li, Liang Yang, Jie Liu, Yang Xu, Jianlin Cui, Shan Ren, Zhi Qi, Yang Gao. (2025) Ertugliflozin induces vasodilation by inhibiting AMPK-mediated mitochondrial fission in vascular smooth muscle cells. EUROPEAN JOURNAL OF PHARMACOLOGY, [PMID:40451567] [10.1016/j.ejphar.2025.177784] |
| 23. Zhenjie Zhang, Wei Wei, Anne Ailina Li, Chenhao Wang, Chengchen Tang, Qing Wang, Lianqun Zhou, Hui Kong. (2025) High accuracy sensor for two-parameter detection of adrenaline and pH in sweat. BIOSENSORS & BIOELECTRONICS, [PMID:40532433] [10.1016/j.bios.2025.117675] |
| 24. Man Xiong, Lei Yang, Xinfang Liu, Sidong Luo, Yeyang Wang. (2025) Circumferentially Aligned Electrospun Vascular Grafts Improves Its Vascular Regeneration and Remodeling in vivo. International Journal of Nanomedicine, [PMID:40535837] [10.2147/IJN.S518283] |
| 25. Zhang Tingting, Tao Qin, Chen Rong, Xu Wen, Xu Jun, Wang Xiaoying. (2025) A portable electrochemical sensor for simultaneous voltammetric determination of multiple neurotransmitters using magnetic composite nanozyme. MICROCHIMICA ACTA, 192 (9): (1-14). [PMID:40788582] [10.1007/s00604-025-07435-z] |
| 26. Zhou Siqi, Ruan Chen, Hou Yuxian, Zou Lina, Wang Rong, Li Gaiping. (2025) Nanozyme-Facilitated In-Situ Fluorogenic Ratiometric Nanosensor for Ultrasensitive and Selective Dopamine Detection. JOURNAL OF FLUORESCENCE, [PMID:41099973] [10.1007/s10895-025-04585-4] |
| 27. Qi Shen, Mengzhu Tong, Lu Cheng, Junxi Li, Yuze Gao, Yibing Huang, Quan Luo. (2025) Self-Calibrating Dual-Signal Cascade Amplification Strategy for Anti-Interference Detection of Carbamate Pesticides via Fluorescent Gold Nanozymes. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, [10.1016/j.colsurfa.2025.138994] |
| 28. Weirui Fang, Xiaoyi Zhu, Xingyu Rong, Zhen Wang, Manjun Du, Shiyu Liu, KangJu Lee, Yaowen Liu. (2026) Facile Fabrication of PVA Nanofibers Decorated With Ratiometric Fluorescent Carbon Dots for Chlorpyrifos Recognition With Deep Learning. eFood, 7 (4): (e70178). [10.1002/efd2.70178] |
| 29. Yanxia Wang, Yanyan Sun, Peng Shen, Wen Zhang, Wenxuan Pan, Xinchen Zhang, Zhaoxia Xu, Xiumei Guan, Yiying Sun, Min Cheng. (2026) AMPK-YAP/TAZ signaling pathway mediates the amelioration of endothelial dysfunction elicited by moderate-intensity exercise-induced wall shear stress. EXPERIMENTAL CELL RESEARCH, 462 (2): (115168). [PMID:42668035] [10.1016/j.yexcr.2026.115168] |
溶液计算器
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