计算溶液所需的质量、体积或浓度。
| 活性类型 | Relation | Activity value | Units | Action Type | 期刊 | PubMed Id | doi | Assay Aladdin ID |
|---|
为什么选择此级别
提供 ≥99% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
避光,-20°C储存。超低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
β-Amyrin acetate is a triterpenoid with potent anti-inflammatory, antifungal, anti-diabetic, anti-hyperlipidemic activities. β-Amyrin acetate can inhibit HMG-CoA reductase activity by locating in the hydrophobic binding cleft of HMG CoA reductase.
In Vitro
β-Amyrin acetate (50 μg/mL) inhibits heat-induced hemolysis and hypotonicity-induced hemolysis of human erythrocytes. β-Amyrin acetate (5-100 μM) has HMG-CoA reductase inhibitory activity by locating in the hydrophobic binding cleft lined with residues Leu562, Gly560, Ala564, Gly569, Ser852, Leu853, Leu857, Met854, Ala856, Ser852 and Ala855 of human HMG CoA reductase. β-Amyrin acetate (7.8-1000 μg/mL, 48 h) inhibits all of the Candida fungal species tested with MIC values ranging from 30 to 250 μg/mL) . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
β-Amyrin acetate (applied on the anterior surface of the right ear, 100 μg/ear, a single dose) significantly inhibits xylene-induced ear edema in mice . β-Amyrin acetate (intraperitoneal injection, 4 mg/100 g, daily for 6 consecutive days) shows significant anti-inflammatory activities (43.6%) in adult albino rats. β-Amyrin acetate (subcutaneous injection, 4 mg/100 g, daily for 10 days ) increases the ATP-phosphohydrolase activity in liver homogenates both in normal and arthritic rats. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Xylene-induced mouse ear topical edema model Dosage: 50 and 100 μg/ear (5 μL) Administration: Applied on the anterior surface of the right ear Result: Inhibited Xylene-induced ear edema in mice Animal Model: Adult albino ratsDosage: 4 mg/100g, daily for 6 consecutive days Administration: Intraperitoneal injection Result: Showed significant anti-inflammatory activities with mean average weight of granulation tissue of 9.2 mg after 6 days.
Form:Solid
规格
别名
β-香树脂醇醋酸盐
规格或纯度
≥99%
英文名称
β-Amyrin acetate
生化机理
β-香树脂醇醋酸酯是一种三萜类化合物，具有很强的抗炎、抗真菌、抗糖尿病和抗高血脂活性。β-香树精醋酸酯可通过位于 HMG CoA 还原酶的疏水结合裂隙中，抑制 HMG-CoA 还原酶的活性。
储存条件
避光,-20°C储存
运输条件
超低温运输
纯度
≥99%
名称和识别符
分子类型
小分子
Smiles
CC(=O)O[C@H]1CC[C@]2([C@H](C1(C)C)CC[C@@]3([C@@H]2CC=C4[C@]3(CC[C@@]5([C@H]4CC(CC5)(C)C)C)C)C)C
Isomeric SMILES
CC(=O)O[C@H]1CC[C@]2([C@H](C1(C)C)CC[C@@]3([C@@H]2CC=C4[C@]3(CC[C@@]5([C@H]4CC(CC5)(C)C)C)C)C)C
PubChem CID
分子量
468.75
技术文档
高级数据
关联靶点（人）
TOP1
Tclin
DNA topoisomerase I
(7553 活性数据)
HL-60
(67320 活性数据)
HT-29
(80576 活性数据)
MCF7
(126967 活性数据)
MRC5
(9203 活性数据)
PANC-1
(6144 活性数据)
PC-3
(62116 活性数据)
SK-MEL-1
(285 活性数据)
SK-OV-3
(52876 活性数据)
A549
(127892 活性数据)
A2780
(11979 活性数据)
HeLa
(62764 活性数据)
SLCO1B1
Tchem
Solute carrier organic anion transporter family member 1B1
(2672 活性数据)
关联靶点（其它种属）
Nos2
Nitric oxide synthase, inducible (3573 活性数据)
Mycobacterium tuberculosis (203094 活性数据)
Trichomonas vaginalis (2376 活性数据)
RAW264.7 (28094 活性数据)
作用机制
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
化学和物理性质
分子量
468.800 g/mol
XLogP3
9.700
氢键供体数Hydrogen Bond Donor Count
0
氢键受体数Hydrogen Bond Acceptor Count
2
可旋转键计数Rotatable Bond Count
2
精确质量Exact Mass
468.397 Da
单同位素质量Monoisotopic Mass
468.397 Da
拓扑极表面积Topological Polar Surface Area
26.300 Ų
重原子数Heavy Atom Count
34
形式电荷Formal Charge
0
复杂度Complexity
897.000
同位素原子数Isotope Atom Count
0
定义的原子立体中心计数Defined Atom Stereocenter Count
8
未定义的原子立体中心计数Undefined Atom Stereocenter Count
0
定义的键立体中心计数Defined Bond Stereocenter Count
0
未定义的键立体中心计数Undefined Bond Stereocenter Count
0
所有立体化学键的总数The total count of all stereochemical bonds
0
共价键合单元计数Covalently-Bonded Unit Count
1
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
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