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2(2-吡啶)酮

规格或纯度: 98%

CAS编号: 19437-26-4
分子式: C₁₁H₈N₂O
分子量: 184.19
Beilstein号: 126598
EC号: 243-067-3
MDL号: MFCD00006288
PubChem编号: 88065

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货号 (SKU)	包装规格	是否现货	价格	数量
D107727-1g	1g	现货
D107727-5g	5g	现货
D107727-10g	10g	现货
D107727-25g	25g	现货
D107727-100g	100g	现货

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吡啶类无卤杂环砌块

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基本描述

别名	2-二吡啶基酮\|双(2-吡啶基)甲酮\|2,2'-二吡啶基甲酮
英文别名	di-2-Pyridyl ketone\|19437-26-4\|Di(pyridin-2-yl)methanone\|dipyridin-2-ylmethanone\|2,2'-Carbonyldipyridine\|Di(2-pyridyl) ketone\|Bis(2-pyridyl) ketone\|Methanone, di-2-pyridinyl-\|2,2'-Dipyridyl ketone\|MFCD00006288\|2-(pyridine-2-carbonyl)pyridine\|Di(2-pyridyl)
规格或纯度	98%
英文名称	Di(2-pyridyl)ketone
生化机理	The Schiff base ligands derived from di-2-pyridyl ketone exhibit antiproliferative activity in SK-N-MC neuroepithelioma (cancer) cells.
运输条件	常规运输
产品介绍	不溶于水。

名称和标识符

EC号	243-067-3
IUPAC Name	dipyridin-2-ylmethanone
INCHI	InChI=1S/C11H8N2O/c14-11(9-5-1-3-7-12-9)10-6-2-4-8-13-10/h1-8H
InChi Key	QPOWUYJWCJRLEE-UHFFFAOYSA-N
Canonical SMILES	C1=CC=NC(=C1)C(=O)C2=CC=CC=N2
Isomeric SMILES	C1=CC=NC(=C1)C(=O)C2=CC=CC=N2
WGK Germany	3
PubChem CID	88065
分子量	184.19
Beilstein号	126598
Reaxy-Rn	126598

化学和物理性质

溶解性	Low solubility in water.
密度	1.169
闪点(℉)	230 °F
闪点(℃)	110 °C
熔点	52-55°C

安全和危险性（GHS）

象形图	Harmful
信号词	Warning
危险声明	H315: Causes skin irritation H319: Causes serious eye irritation H335: May cause respiratory irritation
预防措施声明	P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319
WGK Germany	3
Reaxy-Rn	126598
个人防护装备	dust mask type N95 (US),Eyeshields,Gloves

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参考文献

1. Constantinos G Efthymiou,Anastasia N Georgopoulou,Constantina Papatriantafyllopoulou,Aris Terzis,Catherine P Raptopoulou,Albert Escuer,Spyros P Perlepes. (2010-08-04) Initial employment of di-2-pyridyl ketone as a route to nickel(II)/lanthanide(III) clusters: triangular Ni(2)Ln complexes.. Dalton transactions (Cambridge, England : 2003), 39 ((37)): (8603-8605). [PMID:20680222]
2. Maram T Basha,Jy D Chartres,Namfon Pantarat,Mohammad Akbar Ali,Aminul Huq Mirza,Danuta S Kalinowski,Des R Richardson,Paul V Bernhardt. (2012-03-01) Heterocyclic dithiocarbazate iron chelators: Fe coordination chemistry and biological activity.. Dalton transactions (Cambridge, England : 2003), 41 ((21)): (6536-6548). [PMID:22362375]
3. Anastasia N Georgopoulou,Karrar Al-Ameed,Athanassios K Boudalis,Dimitrios F Anagnostopoulos,Vassilis Psycharis,John E McGrady,Yiannis Sanakis,Catherine P Raptopoulou. (2017-09-19) Site preferences in hetero-metallic [Fe. Dalton transactions (Cambridge, England : 2003), 46 ((38)): (12835-12844). [PMID:28920627]
4. Hana Jansová,Tomáś Šimůnek. (2017-09-22) Cardioprotective Potential of Iron Chelators and Prochelators.. Current medicinal chemistry, 26 ((2)): (288-301). [PMID:28933303]
5. Joanna Masternak,Agnieszka Gilewska,Barbara Barszcz,Iwona Łakomska,Katarzyna Kazimierczuk,Jerzy Sitkowski,Joanna Wietrzyk,Anna Kamecka,Magdalena Milczarek. (2020-08-14) Ruthenium(II) and Iridium(III) Complexes as Tested Materials for New Anticancer Agents.. Materials (Basel, Switzerland), 13 ((16)): (). [PMID:32784666]
6. Tingting Wang,Youxun Liu,Yun Fu,Tengfei Huang,Yun Yang,Shaoshan Li,Changzheng Li. (2017-10-19) Antiproliferative activity of di-2-pyridylhydrazone dithiocarbamate acetate partly involved in p53 mediated apoptosis and autophagy.. International journal of oncology, 51 ((6)): (1909-1919). [PMID:29039462]
7. Xingshuang Guo,Yun Fu,Zhuo Wang,Tingting Wang,Cuiping Li,Tengfei Huang,Fulian Gao,Changzheng Li. (2018-05-17) Di-2-pyridylhydrazone Dithiocarbamate Butyric Acid Ester Exerted Its Proliferative Inhibition against Gastric Cell via ROS-Mediated Apoptosis and Autophagy.. Oxidative medicine and cellular longevity, 2018 (): (4950705-4950705). [PMID:29765497]
8. Sharleen V Menezes,Zaklina Kovacevic,Des R Richardson. (2019-01-27) The metastasis suppressor NDRG1 down-regulates the epidermal growth factor receptor via a lysosomal mechanism by up-regulating mitogen-inducible gene 6.. The Journal of biological chemistry, 294 ((11)): (4045-4064). [PMID:30679310]
9. Szakacs, et al.. (2021) An inventory of lysosomal ABC transporters.. Febs Letters, 594 (): (3965-3985). [PMID:33098571]

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