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1,2-二硬脂酰-sn-甘油-3-磷酸乙醇胺 (DSPE) 偶联聚乙二醇 (DSPE PEG) 是一种兼具亲水性和疏水性的磷脂-聚乙二醇偶联物。聚乙二醇化磷脂是优良的脂质体形成材料,可用于药物递送、基因转染和疫苗递送。磷脂的聚乙二醇化可显著提高包封药物的血液循环时间和稳定性。此外,通过在其表面修饰靶向配体(例如抗体、肽),这些材料还可用于靶向药物递送。
1,2-Distearoyl-sn-Glycero-3-Phosphoethanolamine (DSPE) conjugated Polyethylene Glycol, DSPE PEG is a phospholipid PEG conjugate which has both hydrophilicity and hydrophobility. Pegylated phospholipids are excellent liposome formation materials that can be used for drug delivery, gene transfection and vaccine delivery as well. Pegylation of phospholipids significantly improves the blood circulation time and stability for encapsulated drugs. These materials can also be used for targeted drug delivery by modifying their surfaces with targeting ligands such as antibodies, peptides.