计算溶液所需的质量、体积或浓度。
概述
DDR1-IN-6 is a selective Discoidin Domain Receptor family, member 1 (DDR1) inhibitor with an IC 50 of 9.72 nM. DDR1-IN-6 inhibits auto-phosphorylation DDR1b (Y513) with an IC 50 of 9.7 nM. DDR1-IN-6 has anti-cancer activity
In Vitro
DDR1-IN-6 (compound 1; for 24 hours) inhibits collagen production in human hepatic stellate cell LX-2 (IC 50 =13 nM). DDR1-IN-6 (72 hours) has cytotoxicity in LX-2 cells (CC 50 =3 μM). DDR1-IN-6 (0-30 μM) has anti-proliferation effects on primary tumor cells freshly isolated from PC-07-0024 (IC 50 =5.7 μM of 3 days; IC 50 =2.65 μM of 6 days) and LU-01-0523 derived xenograft (PDX) tumor model (IC 50 >30 μM of 3 days; IC 50 >30 μM of 6 days). MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:DDR1 9.72 nM (IC 50 )
规格
别名
DDR1-输入-6
规格或纯度
≥98%
英文名称
DDR1-IN-6
生化机理
DDR1-IN-6 是一种选择性 Discoidin Domain Receptor 家族成员 1 (DDR1) 抑制剂，IC 50 为 9.72 nM。DDR1-IN-6 可抑制自动磷酸化 DDR1b (Y513)，IC50 为 9.7 nM。DDR1-IN-6 具有抗癌活性。
储存条件
2-8°C储存,避光,干燥
运输条件
低温运输
作用类型
抑制剂
纯度
≥98%
名称和识别符
分子类型
小分子
分子量
433.39
高级数据
化学和物理性质
溶解性
DMSO : 10 mg/mL (23.07 mM; Need ultrasonic)
质检证书(CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
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