,红霉素,红霉素|红霉素碱 | erythromycin|114-07-8|Erythromycin A|E-Mycin|Abomacetin|Erythromycinum|Emgel|Erymax|Ilotycin|Robimycin|Torlamicina|Eryderm|Erythro-Statin|E-Glades|Ery-Tab|Erythromycine|Eritromicina|Erycett,Erythromycin-阿拉丁试剂

货号 (SKU)	包装规格	是否现货
E105345-1g	1g	现货
E105345-5g	5g	现货
E105345-25g	25g	现货
E105345-100g	100g	现货
E105345-500g	500g	现货

基本描述

别名	红霉素\|红霉素碱
英文别名	erythromycin\|114-07-8\|Erythromycin A\|E-Mycin\|Abomacetin\|Erythromycinum\|Emgel\|Erymax\|Ilotycin\|Robimycin\|Torlamicina\|Eryderm\|Erythro-Statin\|E-Glades\|Ery-Tab\|Erythromycine\|Eritromicina\|Erycette\|Pantomicina\|Erygel\|Sansac\|E-Base\|Erythra-Derm\|Erythromycin base\|
规格或纯度	效价 ≥850 μg/mg
英文名称	Erythromycin
生化机理	在转肽步骤抑制延长期，靠结合到核糖体上抑制细菌蛋白合成，对细菌诱发红霉素抗性。抗菌谱: 革兰氏阴性和阳性细菌。属大环内酯抗生素（Macrolide antibiotic） .大环内酯类抗生素。抑制细胞色素p450 3A4和P-糖蛋白。结合50S核糖体亚基并抑制革兰氏阳性和革兰氏阴性细菌中的蛋白质合成。
储存温度	充氩
运输条件	常规运输
备注	如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍	Erythromycin is a potent macrolide inhibitor of CYP3A4 with antiinflammatory and prokinetic properties. Macrolides belong to a group of antibiotics that bind to the 50S ribosomal subunit and inhibit protein synthesis. Erythromycin is derived from Streptomyces erythreus and has been shown to inhibit NF-κB transcriptional activation, which leads to the inhibition of cytokine gene expression of IL-8 and lL-6. This mechanism was shown to occur via calcineruin-independent signaling T lymphocytes. A macrolide antibiotic protein synthesis inhibitor. Erythromycin is an antibiotic produced by growth of certain strains of Streptomyces erythreus. This product is composed largely of erythromycin A with small amounts of erythromycins B and C and is recommended for concentration at 100 mg/L. Concentrations between 50 and 200 mg/L have also proven effective in controlling bacterial growth. Erythromycin has been used as a motilin receptor agonist, to block respiratory glycoconjμgate secretion in human airways in vitro, and for selecting plasmid-cured and recombinant lactococcus lactis MG1363 strains. Erythromycin is a potent macrolide inhibitor of CYP3A4 with antiinflammatory and prokinetic properties. Macrolides belong to a group of antibiotics that bind to the 50S ribosomal subunit and inhibit protein synthesis. Erythromycin is derived from Streptomyces erythreus and has been shown to inhibit NF-κB transcriptional activation, which leads to the inhibition of cytokine gene expression of IL-8 and lL-6. This mechanism was shown to occur via calcineruin-independent signaling T lymphocytes. A macrolide antibiotic protein synthesis inhibitor. Erythromycin is an antibiotic produced by growth of certain strains of Streptomyces erythreus. This product is composed largely of erythromycin A with small amounts of erythromycins B and C and is recommended for concentration at 100 mg/L. Concentrations between 50 and 200 mg/L have also proven effective in controlling bacterial growth. Erythromycin has been used as a motilin receptor agonist, to block respiratory glycoconjugate secretion in human airways in vitro, and for selecting plasmid-cured and recombinant lactococcus lactis MG1363 strains.

产品属性

ALogP	2.7

名称和标识符

EC号	204-040-1
IUPAC Name	(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione
INCHI	InChI=1S/C37H67NO13/c1-14-25-37(10,45)30(41)20(4)27(39)18(2)16-35(8,44)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26/h18-26,28-32,34,40-42,44-45H,14-17H2,1-13H3/t18-,19-,20+,21+,22-,23+,24+,25-,26+,28-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1
InChi Key	ULGZDMOVFRHVEP-RWJQBGPGSA-N
Canonical SMILES	CCC1C(C(C(C(=O)C(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)N(C)C)O)(C)O)C)C)O)(C)O
Isomeric SMILES	CC[C@@H]1[C@@]([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]2C[C@@]([C@H]([C@@H](O2)C)O)(C)OC)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)O)C)C)O)(C)O
WGK Germany	3
RTECS	KF437500
PubChem CID	12560
分子量	733.93
Beilstein号	75279

化学和物理性质

溶解性	熔于乙醇、甲醇、丙酮、氯仿、乙腈和乙酸乙酯，中等程度溶于醚、二氯甲烷和乙酸戊酯。难溶于水。微有引湿性，无臭，味苦。遇酸不稳定。水中溶解度:+/- 3 MG/ML。
密度	1.2
敏感性	对湿度敏感
比旋光度	-74 ° (C=2, EtOH)
熔点	138-140°C

安全和危险性（GHS）

象形图	Health Hazard Harmful
信号词	Danger
危险声明	H319: Causes serious eye irritation H317: May cause an allergic skin reaction H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled
预防措施声明	P261,P305+P351+P338,P280,P302+P352,P321,P501,P284,P304+P340,P272,P333+P313,P362+P364,P264+P265,P337+P317,P342+P316
WGK Germany	3
RTECS	KF437500
Merck Index	3681
个人防护装备	Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

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参考文献

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