5-(羟甲基)脲嘧啶

货号 (SKU)	包装规格	是否现货
H170384-250mg	250mg	期货
H170384-1g	1g	现货
H170384-5g	5g	现货
H170384-10g	10g	现货
H170384-25g	25g	现货
H170384-100g	100g	现货
H170384-500g	500g	现货

基本描述

别名	5-羟甲基尿嘧啶
英文别名	5-Hydroxymethyluracil\|4433-40-3\|5-(Hydroxymethyl)uracil\|5-(HYDROXYMETHYL)PYRIMIDINE-2,4(1H,3H)-DIONE\|5-Oxymethyluracil\|5-Hydroxymethyl uracil\|5-(Hydroxymethyl)pyrimidine-2,4-diol\|Uracil, 5-(hydroxymethyl)-\|2,4(1H,3H)-Pyrimidinedione, 5-(hydroxymethyl)-\|5-
规格或纯度	97%
英文名称	5-(Hydroxymethyl)uracil
储存温度	室温
运输条件	常规运输
产品介绍	5-(Hydroxymethyl)uracil serves as a stable major oxidative modification of thymine formed through the action of ionizing radiation.

名称和标识符

PubChem SID	488185527
IUPAC Name	5-(hydroxymethyl)-1H-pyrimidine-2,4-dione
INCHI	InChI=1S/C5H6N2O3/c8-2-3-1-6-5(10)7-4(3)9/h1,8H,2H2,(H2,6,7,9,10)
InChi Key	JDBGXEHEIRGOBU-UHFFFAOYSA-N
Canonical SMILES	C1=C(C(=O)NC(=O)N1)CO
Isomeric SMILES	C1=C(C(=O)NC(=O)N1)CO
WGK Germany	3
RTECS	YR0513000
PubChem CID	78168
分子量	142.11

数据库链接

PubChem SID	488185527

化学和物理性质

溶解性	Soluble in water. (50 g/L ) at 20°C, DMSO, dimethyl formamide or 100% ethanol.
熔点	>300°C

安全和危险性（GHS）

象形图	Harmful
信号词	Warning
危险声明	H315: Causes skin irritation H319: Causes serious eye irritation H335: May cause respiratory irritation
预防措施声明	P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319
WGK Germany	3
RTECS	YR0513000
个人防护装备	Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter

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参考文献

1. R J Boorstein,A Cummings,D R Marenstein,M K Chan,Y Ma,T A Neubert,S M Brown,G W Teebor. (2001-08-30) Definitive identification of mammalian 5-hydroxymethyluracil DNA N-glycosylase activity as SMUG1.. The Journal of biological chemistry, 276 ((45)): (41991-41997). [PMID:11526119]
2. Yoke W Kow. (2002-10-04) Repair of deaminated bases in DNA.. Free radical biology & medicine, 33 ((7)): (886-893). [PMID:12361800]
3. Masaki Hori,Shuji Yonei,Hiroshi Sugiyama,Katsuhito Kino,Kazuo Yamamoto,Qiu-Mei Zhang. (2003-02-13) Identification of high excision capacity for 5-hydroxymethyluracil mispaired with guanine in DNA of Escherichia coli MutM, Nei and Nth DNA glycosylases.. Nucleic acids research, 31 ((4)): (1191-1196). [PMID:12582238]
4. Jane E A Wibley,Timothy R Waters,Karl Haushalter,Gregory L Verdine,Laurence H Pearl. (2003-06-25) Structure and specificity of the vertebrate anti-mutator uracil-DNA glycosylase SMUG1.. Molecular cell, 11 ((6)): (1647-1659). [PMID:12820976]
5. T Kasama,A Ono,S Izuta. (2003-07-03) Binding activity of replication protein A to single-stranded DNA containing oxidized pyrimidine base.. Nucleic acids research. Supplement (2001), ((1)): (167-168). [PMID:12836317]
6. Anne Grove. (2003-07-23) Surface salt bridges modulate DNA wrapping by the type II DNA-binding protein TF1.. Biochemistry, 42 ((29)): (8739-8747). [PMID:12873134]
7. Ken Akamatsu,Kentaro Fujii,Akinari Yokoya. (2004-03-25) Qualitative and quantitative analyses of the decomposition products that arise from the exposure of thymine to monochromatic ultrasoft X rays and 60Co gamma rays in the solid state.. Radiation research, 161 ((4)): (442-450). [PMID:15038767]
8. Qiu-Mei Zhang,Shin-Ichiro Yonekura,Masashi Takao,Akira Yasui,Hiroshi Sugiyama,Shuji Yonei. (2004-11-10) DNA glycosylase activities for thymine residues oxidized in the methyl group are functions of the hNEIL1 and hNTH1 enzymes in human cells.. DNA repair, 4 ((1)): (71-79). [PMID:15533839]
9. Hauh-Jyun Candy Chen,Chan-Fu Wu,Ju-Li Huang. (2005-01-15) Measurement of urinary excretion of 5-hydroxymethyluracil in human by GC/NICI/MS: correlation with cigarette smoking, urinary TBARS and etheno DNA adduct.. Toxicology letters, 155 ((3)): (403-410). [PMID:15649624]
10. T R Mirsaev. (2008-02-02) Experimental study of hepatoprotective activity of hydroxymethyluracil.. Bulletin of experimental biology and medicine, 143 ((5)): (575-576). [PMID:18239770]
11. T R Mirsaev. (2008-02-02) Correction of morphological shifts in experimental syringomyelia.. Bulletin of experimental biology and medicine, 143 ((5)): (648-649). [PMID:18239792]
12. Kristin Kemmerich,Felix A Dingler,Cristina Rada,Michael S Neuberger. (2012-03-27) Germline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil- and UNG-backup uracil-excision activities and increases cancer predisposition of Ung-/-Msh2-/- mice.. Nucleic acids research, 40 ((13)): (6016-6025). [PMID:22447450]
13. Hideharu Hashimoto,Xing Zhang,Xiaodong Cheng. (2012-06-29) Excision of thymine and 5-hydroxymethyluracil by the MBD4 DNA glycosylase domain: structural basis and implications for active DNA demethylation.. Nucleic acids research, 40 ((17)): (8276-8284). [PMID:22740654]
14. Hideharu Hashimoto,Samuel Hong,Ashok S Bhagwat,Xing Zhang,Xiaodong Cheng. (2012-09-11) Excision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylation.. Nucleic acids research, 40 ((20)): (10203-10214). [PMID:22962365]
15. Berta Mendes,Pedro Silva,Fernando Aveiro,Jorge Pereira,José S Câmara. (2013-03-14) A micro-extraction technique using a new digitally controlled syringe combined with UHPLC for assessment of urinary biomarkers of oxidatively damaged DNA.. PloS one, 8 ((3)): (e58366-e58366). [PMID:23484022]
16. Toni Pfaffeneder,Fabio Spada,Mirko Wagner,Caterina Brandmayr,Silvia K Laube,David Eisen,Matthias Truss,Jessica Steinbacher,Benjamin Hackner,Olga Kotljarova,David Schuermann,Stylianos Michalakis,Olesea Kosmatchev,Stefan Schiesser,Barbara Steigenberger,Nada Raddaoui,Gengo Kashiwazaki,Udo Müller,Cornelia G Spruijt,Michiel Vermeulen,Heinrich Leonhardt,Primo Schär,Markus Müller,Thomas Carell. (2014-05-20) Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA.. Nature chemical biology, 10 ((7)): (574-581). [PMID:24838012]
17. Arturo Papaluca,J Richard Wagner,H Uri Saragovi,Dindial Ramotar. (2018-05-03) UNG-1 and APN-1 are the major enzymes to efficiently repair 5-hydroxymethyluracil DNA lesions in C. elegans.. Scientific reports, 8 ((1)): (6860-6860). [PMID:29717169]
18. Huseyin Cavdar,Murat Senturk,Murat Guney,Serdar Durdagi,Gulru Kayik,Claudiu T Supuran,Deniz Ekinci. (2019-02-09) Inhibition of acetylcholinesterase and butyrylcholinesterase with uracil derivatives: kinetic and computational studies.. Journal of enzyme inhibition and medicinal chemistry, 34 ((1)): (429-437). [PMID:30734597]
19. Anne Grove,Tatiana C Saavedra. (2002-06-12) The role of surface-exposed lysines in wrapping DNA about the bacterial histone-like protein HU.. Biochemistry, 41 ((24)): (7597-7603). [PMID:12056890]
20. Daniel K Rogstad,Pingfang Liu,Artur Burdzy,Susan S Lin,Lawrence C Sowers. (2002-06-19) Endogenous DNA lesions can inhibit the binding of the AP-1 (c-Jun) transcription factor.. Biochemistry, 41 ((25)): (8093-8102). [PMID:12069602]
21. Mayumi Matsubara,Tamon Tanaka,Hiroaki Terato,Eiji Ohmae,Shunsuke Izumi,Katsuo Katayanagi,Hiroshi Ide. (2004-10-07) Mutational analysis of the damage-recognition and catalytic mechanism of human SMUG1 DNA glycosylase.. Nucleic acids research, 32 ((17)): (5291-5302). [PMID:15466595]
22. Rafal Rozalski,Agnieszka Siomek,Daniel Gackowski,Marek Foksinski,Christine Gran,Arne Klungland,Ryszard Olinski. (2004-12-29) Diet is not responsible for the presence of several oxidatively damaged DNA lesions in mouse urine.. Free radical research, 38 ((11)): (1201-1205). [PMID:15621697]
23. Elena K Braithwaite,Padmini S Kedar,Li Lan,Yaroslava Y Polosina,Kenjiro Asagoshi,Vladimir P Poltoratsky,Julie K Horton,Holly Miller,George W Teebor,Akira Yasui,Samuel H Wilson. (2005-07-09) DNA polymerase lambda protects mouse fibroblasts against oxidative DNA damage and is recruited to sites of DNA damage/repair.. The Journal of biological chemistry, 280 ((36)): (31641-31647). [PMID:16002405]
24. S Sh Mananova,I A Pashnina,S V Sibiryak. (2010-12-17) Opposite effects of 5-hydroxymethyluracil on mitogenic response of T cells stimulated through T-cell receptor or through T-cell receptor and CD28 co-receptor molecule.. Bulletin of experimental biology and medicine, 150 ((1)): (58-60). [PMID:21161052]
25. Hideharu Hashimoto,Yiwei Liu,Anup K Upadhyay,Yanqi Chang,Shelley B Howerton,Paula M Vertino,Xing Zhang,Xiaodong Cheng. (2012-03-01) Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation.. Nucleic acids research, 40 ((11)): (4841-4849). [PMID:22362737]
26. Ewelina Zarakowska,Daniel Gackowski,Marek Foksinski,Ryszard Olinski. (2013-09-24) Are 8-oxoguanine (8-oxoGua) and 5-hydroxymethyluracil (5-hmUra) oxidatively damaged DNA bases or transcription (epigenetic) marks?. Mutation research. Genetic toxicology and environmental mutagenesis, 764-765 (): (58-63). [PMID:24055867]
27. Adam B Robertson,John Arne Dahl,Arne Klungland. (2014-06-18) DNA metabolism: bases of DNA repair and regulation.. Nature chemical biology, 10 ((7)): (487-488). [PMID:24937064]

5-(羟甲基)脲嘧啶

库存信息

库存信息

库存信息

库存信息

库存信息

库存信息

库存信息

基本描述

名称和标识符

数据库链接

化学和物理性质

安全和危险性（GHS）

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参考文献