K6PC-5

≥99%

CAS编号: 756875-51-1
分子式: C₁₉H₃₇NO₄
分子量: 343.5
PubChem编号: 11660192

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货号 (SKU)	包装规格	是否现货
K648900-5mg	5mg	期货
K648900-10mg	10mg	期货
K648900-25mg	25mg	期货
K648900-50mg	50mg	期货
K648900-100mg	100mg	期货

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Anti-infection (2825) Filovirus (13) Immunology/Inflammation (1944) SphK (27)

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基本描述

英文别名	9UO46U4GM1 \| DTXSID50997113 \| HY-124042 \| N-(1,3-dihydroxypropan-2-yl)-2-hexyl-3-oxodecanamide \| UNII-9UO46U4GM1 \| F82343 \| Dihydroxyisopropyl capryloylcaprylamide \| MS-25262 \| SCHEMBL23149790 \| K6PC-5, >=98% (HPLC) \| Q27273251 \| CS-0084020 \| C19H37NO4 \|
规格或纯度	≥99%
英文名称	K6PC-5
生化机理	K6PC-5 是一种神经酰胺衍生物，是一种鞘氨醇激酶 1（SPHK1）激活剂，可引起细胞内钙水平的快速瞬时升高。K6PC-5 具有治疗涉及异常角质细胞的皮肤病、神经变性和病毒的潜力。
储存温度	-20°C储存
运输条件	超低温冰袋运输
产品介绍	K6PC-5, a ceramide derivative, is a sphingosine kinase 1(SPHK1) activator and elicites a rapid transient increase in intracellular calcium levels. K6PC-5 has the potential for skin diseases involving abnormal keratinocyte, and neurodegeneration and virus infection research In Vitro K6PC-5 (1-10 μM; 24 h) increases the involucrin and loricrin levels in a dose-dependent manner in normal human epidermal keratinocytes (NHEKs). K6PC-5 promotes differentiation and proliferation of keratinocytes via intracellular Ca 2+ signaling. In addition, K6PC-5 stimulates the phosphorylation of p42/44 extracellular signal-regulated kinase and c-Jun N-terminal kinase. K6PC-5 (1-10 μM; 24 h) promotes fibroblasts proliferation and collagen synthesis in human fibroblasts. K6PC-5 induces intracellular Ca 2+ concentration ([Ca 2+ ] i ) oscillations in human fibroblasts. K6PC-5 (10, 25, and 50 μM; 48 h) significantly attenuates EBOV-induced infection in EBOV-infected EA.hy926 cells. K6PC-5 significantly reduces the virus titers in supernatants of infected cells and strikingly decreased the amount of VP40 in a concentration-dependent manner. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: Normal human epidermal keratinocytes (NHEKs) Concentration: 1 μM, 5 μM, 10 μM Incubation Time: 24 h Result: Increased the involucrin and loricrin levels in a dose-dependent manner. Cell Proliferation AssayCell Line: Human fibroblasts Concentration: 1 μM, 5 μM, 10 μM Incubation Time: 24 h Result: Promoted fibroblast proliferation and procollagen production in human fibroblasts significantly. In Vivo In intrinsically aged hairless mice (56 weeks old), 1% K6PC-5 is applied topically for 2 weeks. This K6PC-5 treatment significantly increases both the number of dermal fibroblasts and collagen production. As a consequence, dermal thickness also increased significantly. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Intrinsically aged hairless mice (56 weeks old)Dosage: 1% (vehicle (PEG:EtOH = 7:3)) Administration: Topical application; twice daily for 2 weeks Result: Enhanced fibroblast proliferation, collagen production, and eventually increased dermal thickness. Form:Solid IC50& Target:SphK1

名称和识别符

IUPAC Name	N-(1,3-dihydroxypropan-2-yl)-2-hexyl-3-oxodecanamide
INCHI	InChI=1S/C19H37NO4/c1-3-5-7-9-11-13-18(23)17(12-10-8-6-4-2)19(24)20-16(14-21)15-22/h16-17,21-22H,3-15H2,1-2H3,(H,20,24)
InChi Key	CGYVFCHCRBGGJG-UHFFFAOYSA-N
Canonical SMILES	CCCCCCCC(=O)C(CCCCCC)C(=O)NC(CO)CO
Isomeric SMILES	CCCCCCCC(=O)C(CCCCCC)C(=O)NC(CO)CO
PubChem CID	11660192
分子量	343.5

化学和物理性质

溶解性	DMSO : 100 mg/mL (291.12 mM; Need ultrasonic)
分子量	343.500 g/mol
XLogP3	4.200
氢键供体数Hydrogen Bond Donor Count	3
氢键受体数Hydrogen Bond Acceptor Count	4
可旋转键计数Rotatable Bond Count	16
精确质量Exact Mass	343.272 Da
单同位素质量Monoisotopic Mass	343.272 Da
拓扑极表面积Topological Polar Surface Area	86.600 Å²
重原子数Heavy Atom Count	24
形式电荷Formal Charge	0
复杂度Complexity	329.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	0
未定义的原子立体中心计数Undefined Atom Stereocenter Count	1
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1

安全和危险性（GHS）

RIDADR	NONHforallmodesoftransport

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名称和识别符

化学和物理性质

安全和危险性（GHS）

质检证书（CoA,COO,BSE/TSE 和分析图谱)

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