KDU731

≥98%

CAS编号: 1610610-48-4
分子式: C₂₂H₁₆N₆O₂
分子量: 396.40
PubChem编号: 76281701

有货

库存信息

关闭

库存信息

关闭

库存信息

关闭

货号 (SKU)	包装规格	是否现货
K649480-1mg	1mg	期货
K649480-5mg	5mg	期货
K649480-10mg	10mg	期货

查看相关系列

PI3K/Akt/mTOR (764) PI4K (21)

Skip to the end of the images gallery

Skip to the beginning of the images gallery

基本描述

规格或纯度	≥98%
英文名称	KDU731
生化机理	KDU731 是一种具有口服活性的隐孢子虫 PI4K 抑制剂，IC50 值为 25 nM，可在体外和体内阻断隐孢子虫感染。KDU731 是一种治疗由隐孢子虫引起的腹泻的候选药物，具有广泛的临床应用前景。
储存温度	-20°C储存
运输条件	超低温冰袋运输
产品介绍	KDU731, an orally active C. parvum PI4K inhibitor with an IC 50 value of 25 nM, blocks Cryptosporidium infection in vitro and in vivo. KDU731 is a promising agent candidate for the treatment of diarrhea caused by Cryptosporidium and meets a broad range of safety . In Vivo KDU731 (orally administration; 7 or 10mg/kg; 16 days) has potent activity against Cryptosporidium in immunocompromised IFN-γ KO mice and dramatically reduces oocyst shedding. KDU731 (orally administration; 5 mg/kg; every 12 hours for 7 days) is tolerated in all calves, and treated calves shed significantly fewer oocysts than vehicle treated calves in their stool. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 6-8 week old C57BL/6 IFN-γ-knockout mice with 10,000 oocysts Dosage: 7 or 10 mg/kg Administration: Orally administration; 7 or 10 mg/kg; 16 days Result: Resulted in significant reduction of oocyst shedding. Animal Model: Neonatal calves with 5 x 10 7 oocysts Dosage: 5 mg/kg Administration: Orally administration; 5 mg/kg; every 12 hours for 7 days Result: Resulted in significant reduction of oocyst shedding in treated calves in their stool. Form:Solid

名称和识别符

IUPAC Name	3-(4-carbamoylphenyl)-N-(5-cyanopyridin-2-yl)-N-methylpyrazolo[1,5-a]pyridine-5-carboxamide
INCHI	InChI=1S/C22H16N6O2/c1-27(20-7-2-14(11-23)12-25-20)22(30)17-8-9-28-19(10-17)18(13-26-28)15-3-5-16(6-4-15)21(24)29/h2-10,12-13H,1H3,(H2,24,29)
InChi Key	YTIYJNWWLQSAAU-UHFFFAOYSA-N
Canonical SMILES	CN(C1=NC=C(C=C1)C#N)C(=O)C2=CC3=C(C=NN3C=C2)C4=CC=C(C=C4)C(=O)N
Isomeric SMILES	CN(C1=NC=C(C=C1)C#N)C(=O)C2=CC3=C(C=NN3C=C2)C4=CC=C(C=C4)C(=O)N
PubChem CID	76281701
MeSH Entry Terms	KDU731
分子量	396.40

化学和物理性质

溶解性	DMSO : 83.33 mg/mL (210.22 mM; Need ultrasonic)
分子量	396.400 g/mol
XLogP3	1.600
氢键供体数Hydrogen Bond Donor Count	1
氢键受体数Hydrogen Bond Acceptor Count	5
可旋转键计数Rotatable Bond Count	4
精确质量Exact Mass	396.133 Da
单同位素质量Monoisotopic Mass	396.133 Da
拓扑极表面积Topological Polar Surface Area	117.000 Å²
重原子数Heavy Atom Count	30
形式电荷Formal Charge	0
复杂度Complexity	697.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	0
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

摩尔浓度计算器

计算溶液所需的质量、体积或浓度。

质量

浓度

体积

分子量

g/mol

稀释计算器

计算配制储备溶液所需的稀释度。

浓度1（C1）

体积 1 (V1)

浓度 2 (C2)

体积 2 (V2)

复溶计算器

复溶计算器允许您快速计算试剂的体积，以复溶小瓶。只需输入试剂的质量和目标浓度，计算器将确定其余部分。

体积（添加到小瓶中）

质量（小瓶）

所需的复溶浓度

KDU731

库存信息

库存信息

库存信息

基本描述

AI解读

名称和识别符

化学和物理性质

质检证书（CoA,COO,BSE/TSE 和分析图谱)

相关文档

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器