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NG-497 is a selective human adipose triglyceride lipase ( ATGL ) inhibitor that targets the enzymatically active patatin-like domain of human ATGL. NG-497 has potential value for tumor research.
In Vitro
NG-497 selectively inactivates human and nonhuman primate ATGL but not structurally and functionally related lipid hydrolases and abolishes human adipocytes in a dose-dependent and reversible manner Lipolysis. NG-497 (40 μM, 80 min) reduces lipolysis-dependent respiration in HepG2 cells without impairing mitochondrial function through off-target effects. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid