计算溶液所需的质量、体积或浓度。
为什么选择此级别
提供 ≥93% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-20°C储存,干燥。超低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
ODN 1585 is a potent inducer of IFN and TNFα production. ODN 1585 is a potent stimulator of NK (natural killer) function. ODN 1585 increases CD8+ T-cell function, including the CD8+ T cell-mediated production of IFN-γ. ODN 1585 induces regression of established melanomas in mice. ODN 1585 can confer complete protection against malaria in mice. ODN 1585 can be used for acute myelogenous leukemia (AML) and malaria research. ODN 1585 can be used as a vaccine adjuvant .
In Vitro
ODN 1585 (3 μg/mL, 48 h) induces PBMC producing IFN-α in the nanogram range. ODN 1585 increases the percentage of CD69+ (early marker of activation) NK cells within 24 h (26±7%). CpG ODN (0.6μg/mL, 18 h) stimulates NK cell-mediated lysis of K562 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
ODN 1585 (50-500 μg, Injection into the tibialis anterior muscle, single) protects 20 to 90% of mice from sporozoite infection . ODN 1585 (100 μg/dose, IP, twice weekly) is determined to be optimal for the induction of antitumor responses in several systems involving comparisons of 30, 100, and 300 μg/injection. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: BALB/c ByJ mice (4- to 8-week-old, female, 6-18 mice in each group) Dosage: 50, 100, 200, or 500 μg (in 50 μL of saline) Administration: Injection into the tibialis anterior muscle, single (at 7, 2, or 1 day(s) prior to sporozoite infection, on the day of infection, and/or at 1 day postinfection) Result: Protected 20 to 90% of mice from infection when the ODN 1585 was administered around the time of sporozoite challenge with doses of 50 to 500 μg. The highest level of protection (90%) resulted from administration of 200 μg of CpG ODN 1585 the day before challenge or 100 μg of CpG ODN 1585 on the day before and the day of challenge.
Form:Solid
规格
规格或纯度
≥93%
英文名称
ODN 1585
生化机理
ODN 1585 能有效诱导 IFN 和 TNFα 的产生。ODN 1585 能有效刺激 NK（自然杀伤细胞）功能。ODN 1585 可增强 CD8+ T 细胞功能，包括 CD8+ T 细胞介导的 IFN-γ 生成。ODN 1585 可诱导雌激素水平下降。
储存条件
-20°C储存,干燥
运输条件
超低温运输
纯度
≥93%
名称和识别符
分子类型
小分子
Smiles
[DNA, d(G-sp-G-G-G-T-C-A-A-C-G-T-T-G-A-G-G-sp-G-sp-G-sp-G-sp-G)]
分子量
6430.00
技术文档
高级数据
化学和物理性质
溶解性
H2O : 20 mg/mL (3.11 mM; Need ultrasonic)
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
常见问题
本产品的纯度是多少？
本产品的化学纯度（含量）为 ≥93%。批次的具体数值以分析证书（COA）为准。
本产品应如何储存？
请于?20 °C、干燥条件下保存。请与干燥剂一同密封保存，本品对湿气敏感。
本产品如何运输？
本产品采用保温箱配冰袋运输。收货后请立即拆包，并按上述储存条件保存。
本产品的 CAS 号、分子式和分子量是多少？
本产品的 CAS 号为 386832-46-8，分子量为 6430.00 g/mol。
如何获取批次专用COA？
每个订单都会随附分析证书（COA），您也可以从账户订单历史中下载。如需订购前的COA，请联系您的客户代表，或使用PDP上的"申请COA"按钮——我们将提供代表性批次的COA。
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
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