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帕莫酸

规格或纯度: 97%
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货号 (SKU) 包装规格 是否现货 价格 数量
P106763-5g
 5g 现货 Stock Image
P106763-25g
 25g 现货 Stock Image
P106763-100g
 100g 现货 Stock Image
P106763-250g
 250g 现货 Stock Image
P106763-500g
 500g 现货 Stock Image
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GPR35 Agonist
main product photo

基本描述

别名 扑酸|4,4'-亚甲基二(3-羟基-2-萘甲酸|亚甲基双羟萘酸|4,4'-亚甲基双(3-羟基-2-萘甲酸)
英文别名 PAMOIC ACID|130-85-8|Embonic acid|4,4'-Methylenebis(3-hydroxy-2-naphthoic acid)|Pamosaeure|2-Naphthalenecarboxylic acid, 4,4'-methylenebis[3-hydroxy-|NSC30188|4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic acid|MFCD000040
规格或纯度 97%
英文名称 Pamoic acid
生化机理 Pamoic acid, also known as embonic acid, is the free acid form of pamoates or embonates. It has shown to have agonist activity for GPR35, an orphan G protein coupled receptor.
应用 A naphthoic acid derivative.
储存温度 充氩
运输条件 常规运输
产品介绍

实际上不溶于水、乙酸、乙醇、乙醚和苯；溶于硝基苯和吡啶，微溶于氯仿。A naphthoic acid derivative.

A naphthoic acid derivative.

名称和标识符

PubChem SID 488180825
EC号 204-998-0
IUPAC Name 4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic acid
INCHI InChI=1S/C23H16O6/c24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29/h1-10,24-25H,11H2,(H,26,27)(H,28,29)
InChi Key WLJNZVDCPSBLRP-UHFFFAOYSA-N
Canonical SMILES C1=CC=C2C(=C1)C=C(C(=C2CC3=C(C(=CC4=CC=CC=C43)C(=O)O)O)O)C(=O)O
Isomeric SMILES C1=CC=C2C(=C1)C=C(C(=C2CC3=C(C(=CC4=CC=CC=C43)C(=O)O)O)O)C(=O)O
WGK Germany 3
RTECS QL2180000
PubChem CID 8546
分子量 388.37
Beilstein号 901319
Reaxy-Rn 901319

化学和物理性质

溶解性 Soluble in nitrobenzene, pyridine.不溶于水，可溶于硝基苯，极微溶于氯仿，不溶于乙醚,醇,苯
密度 1.499
熔点 ≥300°C

安全和危险性（GHS）

象形图
ghs09

Environmental Hazard

ghs07

Harmful
信号词 Warning
危险声明 H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
H302: Harmful if swallowed
H400: Very toxic to aquatic life
H410: Very toxic to aquatic life with long lasting effects
预防措施声明 P261,P305+P351+P338,P273,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P362+P364,P391,P330,P264+P265,P301+P317,P337+P317,P332+P317,P319
WGK Germany 3
RTECS QL2180000
Reaxy-Rn 901319
Merck Index 7005
个人防护装备 dust mask type N95 (US),Eyeshields,Gloves

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参考文献

1. Zhao P, Sharir H, Kapur A, Cowan A, Geller EB, Adler MW, Seltzman HH, Reggio PH, Heynen-Genel S, Sauer M, Chung TD, Bai Y, Chen W, Caron MG, Barak LS, Abood ME.  (2010)  Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity..  Mol Pharmacol,  78  (4):  (560-8).  [PMID:20826425]
2. T Saesmaa.  (1989-02-03)  Identification and purity determination of benzathine and embonate salts of some beta-lactam antibiotics by thin-layer chromatography..  Journal of chromatography,  463  ((2)):  (469-473).  [PMID:2708491]
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6. M Jørgensen.  (1998-11-21)  Quantitative determination of pamoic acid in dog and rat serum by automated ion-pair solid-phase extraction and reversed-phase high-performance liquid chromatography..  Journal of chromatography. B, Biomedical sciences and applications,  716  ((1-2)):  (315-323).  [PMID:9824246]
7. Jennifer L Best,Carlos A Amezcua,Bernhard Mayr,Lawrence Flechner,Christopher M Murawsky,Beverly Emerson,Tsaffrir Zor,Kevin H Gardner,Marc Montminy.  (2004-12-09)  Identification of small-molecule antagonists that inhibit an activator: coactivator interaction..  Proceedings of the National Academy of Sciences of the United States of America,  101  ((51)):  (17622-17627).  [PMID:15585582]
8. Humphrey Fonge,Satish K Chitneni,Jin Lixin,Kathleen Vunckx,Kristof Prinsen,Johan Nuyts,Luc Mortelmans,Guy Bormans,Yicheng Ni,Alfons Verbruggen.  (2007-10-13)  Necrosis avidity of (99m)Tc(CO)3-labeled pamoic acid derivatives: synthesis and preliminary biological evaluation in animal models of necrosis..  Bioconjugate chemistry,  18  ((6)):  (1924-1934).  [PMID:17929883]
9. Corinne Hazan,François Boudsocq,Virginie Gervais,Olivier Saurel,Marion Ciais,Christophe Cazaux,Jerzy Czaplicki,Alain Milon.  (2008-04-18)  Structural insights on the pamoic acid and the 8 kDa domain of DNA polymerase beta complex: towards the design of higher-affinity inhibitors..  BMC structural biology,  8  ():  (22-22).  [PMID:18416825]
10. Chad Deisenroth,Aaron R Thorner,Takeharu Enomoto,Charles M Perou,Yanping Zhang.  (2010-06-16)  Mitochondrial Hep27 is a c-Myb target gene that inhibits Mdm2 and stabilizes p53..  Molecular and cellular biology,  30  ((16)):  (3981-3993).  [PMID:20547751]
11. Kristof Prinsen,Junjie Li,Hubert Vanbilloen,Peter Vermaelen,Ellen Devos,Luc Mortelmans,Guy Bormans,Yicheng Ni,Alfons Verbruggen.  (2010-06-29)  Development and evaluation of a 68Ga labeled pamoic acid derivative for in vivo visualization of necrosis using positron emission tomography..  Bioorganic & medicinal chemistry,  18  ((14)):  (5274-5281).  [PMID:20580560]
12. T Saesmaa,A M Tötterman.  (1990-01-01)  Dissolution studies on ampicillin embonate and amoxycillin embonate..  Journal of pharmaceutical and biomedical analysis,  8  ((1)):  (61-65).  [PMID:2102266]
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