计算溶液所需的质量、体积或浓度。
为什么选择此级别
提供 ≥99% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-20°C储存。超低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
PS10 is a novel, potent and ATP-competitive pan- PDK inhibitor, inhibits all PDK isoforms with IC 50 of 0.8 μM, 0.76 μM, 2.1 μM and 21.3 μM for PDK2, PDK4, PDK1, and PDK3, respectively. PS10 shows high affinity for PDK2 ( K d = 239 nM) than for Hsp90 (K d = 47 μM) PS10 improves glucose tolerance, stimulates myocardial carbohydrate oxidation in diet-induced obesity. PS10 has the potential for the investigation of diabetic cardiomyopathy .PDK: pyruvate dehydrogenase kinase
In Vitro
PS10 shows a higher affinity of PS10 for PDK2 (K d = 239 nM) than for Hsp90 (K d = 47,000 nM). PS10 is less potent than cycloheximide in HeLa cells, it shows an IC 50 value of 284 μM for the growth inhibition and PS10 has low toxicity in cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
PS10 (Intraperitoneal injection; 70 mg/kg; single dose) treatment lead to 11- and 23-fold higher PDC activity in heart and liver, respectively. Meanwhile, there results in a 1.4-fold enhancement of PDC activity in kidneys compared with vehicle-group . PS10 (Intraperitoneal injection; 70 mg/kg; 3 days) treatment results that thePDC activity profiles and the phospho-E1α subunit level is similar to the single-dose. Notably, the three-day treatment attenuates the enhancement of PDK activity in heart . PS10 (intraperitoneal injection; 70 mg/kg; 4 weeks) is treated in mice and subjected to a glucose tolerance test. when challenged with 1.5 g/kg glucose, the plasma glucose level in the vehicle-treated control is at 200 mg/dl at 0 min, peaks at 482 mg/dl at 30 min, and reduces to 210 mg/dl at 120 min. In PS10-treated DIO mice, the glucose level at 168 mg/dl at 0 min is lower than that in vehicle-treated animals, reachs 312 mg/dl at 30 min, and returns to 163 mg/dl at 120 min . PS10 (intraperitoneal injection; 70 mg/kg) and DCA both stimulates flux through PDC as measured by the appearance of hyperpolarized [ 13 C]bicarbonate. It shows similar glucose tolerance response to glucose challenge restores PDC activity in the DIO mouse hearts. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: C57BL/6J male mice at 6 to 8 weeks oldDosage: 70 mg/kg/day Administration: Intraperitoneal injection Result: Improved glucose tolerance in the intact animal.
Form:Solid
IC50& Target:IC50: 0.8 μM (PDK2),0.76 μM (PDK4),2.1 μM (PDK3),21.3 μM (PDK1)
规格
规格或纯度
≥99%
英文名称
PS10
生化机理
PS10 是一种新型、强效的 ATP 竞争性泛 PDK 抑制剂，可抑制所有 PDK 同工酶，对 PDK2、PDK4、PDK1 和 PDK3 的 IC 50 分别为 0.8 μM、0.76 μM、2.1 μM 和 21.3 μM。PS10 对 PDK2 的亲和力（K d = 239 nM）高于对 Hsp90 的亲和力（K d = 239 nM）。
储存条件
-20°C储存
运输条件
超低温运输
作用类型
抑制剂
纯度
≥99%
名称和识别符
分子类型
小分子
分子量
323.32
技术文档
高级数据
化学和物理性质
溶解性
DMSO : 62.5 mg/mL (193.31 mM; Need ultrasonic)
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
常见问题
本产品的纯度是多少？
本产品的化学纯度（含量）为 ≥99%。批次的具体数值以分析证书（COA）为准。
本产品应如何储存？
请于?20 °C条件下保存。需冷冻保存以维持规定的有效期。
本产品如何运输？
本产品采用保温箱配冰袋运输。收货后请立即拆包，并按上述储存条件保存。
本产品的 CAS 号、分子式和分子量是多少？
本产品的 CAS 号为 1564265-82-2，分子式为 C14H13NO6S，分子量为 323.32 g/mol。
如何获取批次专用COA？
每个订单都会随附分析证书（COA），您也可以从账户订单历史中下载。如需订购前的COA，请联系您的客户代表，或使用PDP上的"申请COA"按钮——我们将提供代表性批次的COA。
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
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