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DL-闪白酸

规格或纯度: >98.0%
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货号 (SKU) 包装规格 是否现货 价格 数量
S161215-5g
 5g 现货 Stock Image
S161215-25g
 25g 期货 Stock Image
S161215-100g
 100g 现货 Stock Image
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羧酸 羰基化合物
main product photo

基本描述

别名 2-羟基异己酸|2-羟基-4-甲基戊酸
英文别名 2-Hydroxy-4-methylpentanoic acid|498-36-2|DL-leucic acid|2-Hydroxy-4-methylvaleric acid|2-Hydroxyisocaproic acid|Leucic acid|leucinic acid|alpha-Hydroxyisocaproic acid|10303-64-7|Pentanoic acid, 2-hydroxy-4-methyl-|2-HYDROXY-4-METHYL-PENTANOIC ACID|DL-2-H
规格或纯度 >98.0%
英文名称 DL-Leucic Acid
运输条件 常规运输
产品介绍


application：

Leucic Acid is an intermediate used to prepare aryl-substituted indazole derivatives as modulators and inhibitors of protein kinases in the treatment of tumor growth, cellular proliferation, and angiogenesis.

名称和标识符

PubChem SID 488186718
IUPAC Name 2-hydroxy-4-methylpentanoic acid
INCHI InChI=1S/C6H12O3/c1-4(2)3-5(7)6(8)9/h4-5,7H,3H2,1-2H3,(H,8,9)
InChi Key LVRFTAZAXQPQHI-UHFFFAOYSA-N
Canonical SMILES CC(C)CC(C(=O)O)O
Isomeric SMILES CC(C)CC(C(=O)O)O
WGK Germany 3
PubChem CID 92779
分子量 132.16

化学和物理性质

溶解性 Soluble in water. (82 g/L) at 25°C
熔点 74-80°C

安全和危险性（GHS）

象形图
ghs07

Harmful
信号词 Warning
危险声明 H315: Causes skin irritation
H319: Causes serious eye irritation
预防措施声明 P305+P351+P338,P280,P302+P352,P321,P264,P362+P364,P264+P265,P337+P317,P332+P317
WGK Germany 3

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参考文献

1. M Friedrich,P W Wüstenberg,U Hinz,J Schröder,R Noack,H Klinkmann.  (1989-02-01)  [The growth of rats in renal compensatory adaptation in feeding with a supplemented diet of hydroxy-analogs of essential amino acids]..  Zeitschrift fur Urologie und Nephrologie,  82  ((2)):  (105-112).  [PMID:2728631]
2. B Bossow,C Wandrey.  (1987-01-01)  Continuous enzymatically catalyzed production of L-leucine from the corresponding racemic hydroxy acid..  Annals of the New York Academy of Sciences,  506  ():  (325-336).  [PMID:3124688]
3. K P Boebel,D H Baker.  (1982-10-01)  Comparative utilization of the alpha-keto and D- and L-alpha-hydroxy analogs of leucine, isoleucine and valine by chicks and rats..  The Journal of nutrition,  112  ((10)):  (1929-1939).  [PMID:7119896]
4. H Drechsel,A Thieken,R Reissbrodt,G Jung,G Winkelmann.  (1993-05-01)  Alpha-keto acids are novel siderophores in the genera Proteus, Providencia, and Morganella and are produced by amino acid deaminases..  Journal of bacteriology,  175  ((9)):  (2727-2733).  [PMID:8478334]
5. K D Webster,M W Anders.  (1989-09-01)  Bioactivation mechanism of L-thiomorpholine-3-carboxylic acid..  Archives of biochemistry and biophysics,  273  ((2)):  (562-571).  [PMID:2774567]
6. L J Spaapen,D Ketting,S K Wadman,L Bruinvis,M Duran.  (1987-01-01)  Urinary D-4-hydroxyphenyllactate, D-phenyllactate and D-2-hydroxyisocaproate, abnormalities of bacterial origin..  Journal of inherited metabolic disease,  10  ((4)):  (383-390).  [PMID:3126358]
7. E Haan,G Brown,A Bankier,D Mitchell,S Hunt,J Blakey,G Barnes.  (1985-05-01)  Severe illness caused by the products of bacterial metabolism in a child with a short gut..  European journal of pediatrics,  144  ((1)):  (63-65).  [PMID:4018104]
8. C Jakobs,L Sweetman,W L Nyhan.  (1984-07-16)  Hydroxy acid metabolites of branched-chain amino acids in amniotic fluid..  Clinica chimica acta; international journal of clinical chemistry,  140  ((2)):  (157-166).  [PMID:6467607]
9. T Kuhara,T Shinka,Y Inoue,M Matsumoto,M Yoshino,Y Sakaguchi,I Matsumoto.  (1983-09-30)  Studies of urinary organic acid profiles of a patient with dihydrolipoyl dehydrogenase deficiency..  Clinica chimica acta; international journal of clinical chemistry,  133  ((2)):  (133-140).  [PMID:6688766]
10. M Sakko,L Tjäderhane,T Sorsa,P Hietala,A Järvinen,P Bowyer,R Rautemaa.  (2012-04-10)  2-Hydroxyisocaproic acid (HICA): a new potential topical antibacterial agent..  International journal of antimicrobial agents,  39  ((6)):  (539-540).  [PMID:22483561]
11. Anders H Honoré,Stina D Aunsbjerg,Parvaneh Ebrahimi,Michael Thorsen,Connie Benfeldt,Susanne Knøchel,Thomas Skov.  (2015-11-18)  Metabolic footprinting for investigation of antifungal properties of Lactobacillus paracasei..  Analytical and bioanalytical chemistry,  408  ((1)):  (83-96).  [PMID:26573172]
12. Georgia Lytra,Celine Franc,Margaux Cameleyre,Jean-Christophe Barbe.  (2017-06-08)  Study of Substituted Ester Formation in Red Wine by the Development of a New Method for Quantitative Determination and Enantiomeric Separation of Their Corresponding Acids..  Journal of agricultural and food chemistry,  65  ((24)):  (5018-5025).  [PMID:28590732]
13. Xinyang Wang,Xinshu Zhao,Jing Chou,Jiaying Yu,Tongshu Yang,Liyan Liu,Fengmin Zhang.  (2018-08-15)  Taurine, glutamic acid and ethylmalonic acid as important metabolites for detecting human breast cancer based on the targeted metabolomics..  Cancer biomarkers : section A of Disease markers,  23  ((2)):  (255-268).  [PMID:30103303]
14. David Selis,Yashika Pande,Cristine Smoczer,Michelle Wheater,Jamal Alhabeil,Susan Paurazas,Mazin Askar.  (2019-03-19)  Cytotoxicity and Genotoxicity of a New Intracanal Medicament, 2-hydroxyisocaproic Acid-An In\xa0Vitro Study..  Journal of endodontics,  45  ((5)):  (578-583).  [PMID:30879773]
15. Veronika Walser,Markus Kranzler,Monika Ehling-Schulz,Timo D Stark,Thomas F Hofmann.  (2021-04-04)  Structure Revision of Isocereulide A, an Isoform of the Food Poisoning Emetic Bacillus cereus Toxin Cereulide..  Molecules (Basel, Switzerland),  26  ((5)):  ().  [PMID:33806334]
16. Si Wu,Si Chen,Xin Dong,Guangguo Tan,Wuhong Li,Ziyang Lou,Zhenyu Zhu,Yifeng Chai.  (2014-12-02)  Lipidomic profiling reveals significant alterations in lipid biochemistry in hypothyroid rat cerebellum and the therapeutic effects of Sini decoction..  Journal of ethnopharmacology,  159  ():  (262-273).  [PMID:25435288]
17. Rafał P Maksym,Andrea Ghirardo,Wei Zhang,Veronica von Saint Paul,Birgit Lange,Birgit Geist,Mohammad-Reza Hajirezaei,Jörg-Peter Schnitzler,Anton R Schäffner.  (2018-06-26)  The Defense-Related Isoleucic Acid Differentially Accumulates in Arabidopsis Among Branched-Chain Amino Acid-Related 2-Hydroxy Carboxylic Acids..  Frontiers in plant science,  9  ():  (766-766).  [PMID:29937770]
18. Biswapriya B Misra,Sobha R Puppala,Anthony G Comuzzie,Michael C Mahaney,John L VandeBerg,Michael Olivier,Laura A Cox.  (2019-04-06)  Analysis of serum changes in response to a high fat high cholesterol diet challenge reveals metabolic biomarkers of atherosclerosis..  PloS one,  14  ((4)):  (e0214487-e0214487).  [PMID:30951537]
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