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| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| T171759-100mg |
100mg |
期货  |
|
| 英文别名 | TELOTRISTAT ETHYL|1033805-22-9|LX1606|LX 1606|LX-1606|Xermelo|LX 1032|Telotristat ethyl [USAN]|(S)-Ethyl 2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoate|LX-1032|UNII-8G388 |
|---|---|
| 规格或纯度 | 97% |
| 英文名称 | Telotristat |
| 储存温度 | 室温 |
| 运输条件 | 常规运输 |
| ALogP | 5.1 |
|---|
| IUPAC Name | ethyl (2S)-2-amino-3-[4-[2-amino-6-[(1R)-1-[4-chloro-2-(3-methylpyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyrimidin-4-yl]phenyl]propanoate |
|---|---|
| INCHI | InChI=1S/C27H26ClF3N6O3/c1-3-39-25(38)20(32)12-16-4-6-17(7-5-16)21-14-23(35-26(33)34-21)40-24(27(29,30)31)19-9-8-18(28)13-22(19)37-11-10-15(2)36-37/h4-11,13-14,20,24H,3,12,32H2,1-2H3,(H2,33,34,35)/t20-,24+/m0/s1 |
| InChi Key | MDSQOJYHHZBZKA-GBXCKJPGSA-N |
| Canonical SMILES | CCOC(=O)C(CC1=CC=C(C=C1)C2=CC(=NC(=N2)N)OC(C3=C(C=C(C=C3)Cl)N4C=CC(=N4)C)C(F)(F)F)N |
| Isomeric SMILES | CCOC(=O)[C@H](CC1=CC=C(C=C1)C2=CC(=NC(=N2)N)O[C@H](C3=C(C=C(C=C3)Cl)N4C=CC(=N4)C)C(F)(F)F)N |
| PubChem CID | 25181577 |
| 分子量 | 574.99 |
| CAS Registry No. | 1033805-22-9 |
|---|---|
| PubChem CID | 25181577 |
| ChEMBL Ligand | CHEMBL2105695 |
| DrugCentral Ligand | 5214 |
输入批号以搜索COA:
| 1. Kulke MH, Hörsch D, Caplin ME, Anthony LB, Bergsland E, Öberg K, Welin S, Warner RR, Lombard-Bohas C, Kunz PL et al.. (2017) Telotristat Ethyl, a Tryptophan Hydroxylase Inhibitor for the Treatment of Carcinoid Syndrome.. J Clin Oncol, 35 (1): (14-23). [PMID:27918724] |
| 2. Margolis KG, Stevanovic K, Li Z, Yang QM, Oravecz T, Zambrowicz B, Jhaver KG, Diacou A, Gershon MD. (2014) Pharmacological reduction of mucosal but not neuronal serotonin opposes inflammation in mouse intestine.. Gut, 63 (6): (928-37). [PMID:23749550] |
| 3. Lamarca A, Barriuso J, McNamara MG, Hubner RA, Valle JW. (2016) Telotristat ethyl: a new option for the management of carcinoid syndrome.. Expert Opin Pharmacother, 17 (18): (2487-2498). [PMID:27817224] |
| 4. Kim JJ, Wang H, Terc JD, Zambrowicz B, Yang QM, Khan WI. (2015) Blocking peripheral serotonin synthesis by telotristat etiprate (LX1032/LX1606) reduces severity of both chemical- and infection-induced intestinal inflammation.. Am J Physiol Gastrointest Liver Physiol, 309 (6): (G455-65). [PMID:26206858] |
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