三(2-氯乙基)胺盐酸盐

  • ≥98%
有货

库存信息

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库存信息

关闭
货号 (SKU) 包装规格 是否现货 价格 数量
T472651-5g
5g 期货 Stock Image
T472651-25g
25g 期货 Stock Image

基本描述

英文别名 CS-6361 | Trichlormethin | Triethylamine,2',2''-trichloro-, hydrochloride | Tris-N-lost | VEAUDLLZYJVHRI-UHFFFAOYSA-N | HN3 hydrochloride | NSC260424 | AS-63894 | NSC 30211 | Trichlor-triaethylamin-hydrochlorid | Trimustine hydrochloride | Tris(2-chloroet
规格或纯度 ≥98%
英文名称 Tris(2-chloroethyl)amine hydrochloride

AI解读

关联靶点(人)

LMNA Tbio Prelamin-A/C (36751 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

关联靶点(其它种属)

rep Replicase polyprotein 1ab (378 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
groL GroEL/GroES (1042 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

分子类型 小分子
IUPAC Name 2-chloro-N,N-bis(2-chloroethyl)ethanamine;hydrochloride
INCHI InChI=1S/C6H12Cl3N.ClH/c7-1-4-10(5-2-8)6-3-9;/h1-6H2;1H
InChi Key VEAUDLLZYJVHRI-UHFFFAOYSA-N
Canonical SMILES C(CCl)N(CCCl)CCCl.Cl
Isomeric SMILES C(CCl)N(CCCl)CCCl.Cl
PubChem CID 61220
UN Number 2928
分子量 241

化学和物理性质

闪点(℉) Not applicable
闪点(℃) Not applicable
熔点 127-130℃ (lit.)
分子量 241.000 g/mol
XLogP3
氢键供体数Hydrogen Bond Donor Count 1
氢键受体数Hydrogen Bond Acceptor Count 1
可旋转键计数Rotatable Bond Count 6
精确质量Exact Mass 240.977 Da
单同位素质量Monoisotopic Mass 238.98 Da
拓扑极表面积Topological Polar Surface Area 3.200 Ų
重原子数Heavy Atom Count 11
形式电荷Formal Charge 0
复杂度Complexity 55.700
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 0
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 2

安全和危险性(GHS)

象形图 GHS06,   GHS08,   GHS05
信号词 Danger
危险声明

H351: 怀疑引起遗传缺陷

H314: 造成严重的皮肤灼伤和眼睛损伤

H300: 吞咽致命

预防措施声明

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。

P321: 特殊处理(请参阅此标签上的...)。

P405: 密闭存放

P501: 将内容物/容器处理到。。。

P264: 处理后要彻底洗手。

P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。

P270: 使用本产品时,请勿进食、饮水或吸烟。

P301+P330+P331: 如误吞咽:漱口。不要诱导呕吐。

P304+P340: 如误吸入:将人转移到空气新鲜处,保持呼吸舒适体位。

P363: 再次使用之前,请清洗受污染的衣物。

P330: 漱口

P203: 使用前,获取、阅读并遵守所有安全说明。

P301+P316: 如果吞咽:立即寻求紧急医疗救助。

P305+P354+P338: 如果进入眼睛:立即用水冲洗几分钟。取下隐形眼镜(如果有的话),并且操作简单。继续冲洗。

P318: 如果暴露或担心,请就医。

P302+P361+P354: 如果接触皮肤:立即脱掉所有被污染的衣服。立即用水冲洗几分钟。

P316: 立即寻求紧急医疗救助。

个人防护装备 dust mask type N95 (US),Eyeshields,Gloves
RIDADR UN 2928 8(6.1) / PGI

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:

参考文献

1. I Sýkora,D Gandalovicová.  (1992-04-01)  Trichlormethine hydrochloride and correlation of its mutagenic and toxic effects on male germ cells in mice..  Mutation research,  266  ((2)): (291-297).  [PMID:1373838]
2. N I Ryabchenko,V Jurásková,B P Ivannik,A V Konov,V Drásil.  (1991-02-01)  The effects of radiation and alkylating agents on chromatin degradation in normal and tumour lymphoid cells..  General physiology and biophysics,  10  ((1)): (41-48).  [PMID:1651271]
3. N I Riabchenko,V Jurasková,B P Ivannik,A V Konov,V Drasil.  (1991-01-01)  [The effect of irradiation and alkylating agents on chromatin breakdown in normal and malignant lymphoid cells]..  Radiobiologiia,  31  ((1)): (22-26).  [PMID:2008520]
4. []}].  (1990-01-01)  Trichlormethine (trimustine hydrochloride)..  IARC monographs on the evaluation of carcinogenic risks to humans,  50  (143-149).  [PMID:2292796]
5. T Hiratsuka.  (1988-05-31)  Cross-linking of three heavy-chain domains of myosin adenosinetriphosphatase with a trifunctional alkylating reagent..  Biochemistry,  27  ((11)): (4110-4114).  [PMID:2970866]
6. V Ujházy,J Siracký.  (1980-01-01)  Heterogeneity of tumor cells..  Antibiotics and chemotherapy,  28  (120-122).  [PMID:6998360]
7. I Sýkora,V Vortel,O Marhan,A Dynterová.  (1981-01-01)  Carcinogenicity of trichloromethine hydrochloride (TS-160 Spofa) and morphological damage after its intraamniotic injection..  Neoplasma,  28  ((5)): (565-574).  [PMID:7312075]
8. D B Wildenauer,H Reuther,J Remien.  (1980-12-02)  Reactions of the alkylating agent tris(2-chloroethyl)-amine with the erythrocyte membrane. Effects on shape changes of human erythrocytes and ghosts..  Biochimica et biophysica acta,  603  ((1)): (101-116).  [PMID:7448181]
9. G L Gresham,G S Groenewold,J E Olson.  (2001-02-17)  Identification of the nitrogen-based blister agents bis(2-chloroethyl)methylamine (HN-2) and tris(2-chloroethyl)amine (HN-3) and their hydrolysis products on soil using ion trap secondary ion mass spectrometry..  Journal of mass spectrometry : JMS,  35  ((12)): (1460-1469).  [PMID:11180637]
10. Thong-Hiang Yeo,Mer-Lin Ho,Weng-Keong Loke.  (2008-02-14)  Development of a liquid chromatography-multiple reaction monitoring procedure for concurrent verification of exposure to different forms of mustard agents..  Journal of analytical toxicology,  32  ((1)): (51-56).  [PMID:18269793]
11. Pravin Kumar,Anshoo Gautam,Chandra Jatav Prakash,Abdhesh Kumar,K Ganeshan,Uma Pathak,R Vijayaraghavan.  (2010-02-19)  Ameliorative effect of DRDE 07 and its analogues on the systemic toxicity of sulphur mustard and nitrogen mustard in rabbit..  Human & experimental toxicology,  29  ((9)): (747-755).  [PMID:20164158]
12. E G Ankel,B J Ring,C S Lai,J S Holcenberg.  (1986-01-01)  The lack of effects of alkylating agents on mammalian cell membranes..  International journal of tissue reactions,  ((5)): (347-354).  [PMID:3023251]
13. L Szinicz,G J Albrecht,N Weger.  (1981-01-01)  Effect of various compounds on the reaction of tris-(2-chloroethyl)amine with ribonucleic acid in vitro and on its toxicity in mice..  Arzneimittel-Forschung,  31  ((10)): (1713-1717).  [PMID:6172133]
14. D Slamenová,M Dusinská,E Budayová,A Gabelová.  (1983-03-01)  The genetic effects of the cytostatic drug TS160 on Chinese hamster fibroblasts in vitro..  Mutation research,  116  ((3-4)): (431-440).  [PMID:6188044]
15. J R Stuff,R L Cheicante,H D Durst,J L Ruth.  (1999-08-24)  Detection of the chemical warfare agents bis-(2-chloroethyl)ethylamine (HN-1) and tris-(2-chloroethyl)amine (HN-3) in air..  Journal of chromatography. A,  849  ((2)): (529-540).  [PMID:10457448]
16. S M Bertoluzzo,A Bollini,M Rasia,A Raynal.  (2000-02-08)  Kinetic model for erythrocyte aggregation..  Blood cells, molecules & diseases,  25  ((5-6)): (339-349).  [PMID:10660481]
17. Hiroyuki Morimoto,Sean H Wiedemann,Akitake Yamaguchi,Shinji Harada,Zhihua Chen,Shigeki Matsunaga,Masakatsu Shibasaki.  (2006-04-06)  Trichloromethyl ketones as synthetically versatile donors: application in direct catalytic mannich-type reactions and the stereoselective synthesis of azetidines..  Angewandte Chemie (International ed. in English),  45  ((19)): (3146-3150).  [PMID:16596693]
18. Qing Liu,Yanxia Teng,Yong Niu,Qingjun Liu,Huawei Duan,Ping Bin,Yuxin Zheng,Yufei Dai.  (2009-11-03)  [Study on the influence factors of human peripheral blood B lymphocyte transformation by Epstein-Barr virus]..  Wei sheng yan jiu = Journal of hygiene research,  38  ((5)): (528-530).  [PMID:19877506]

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