JOURNAL OF MOLECULAR STRUCTURE
·
2019
·
IF 2.12
Xue-Pu Feng,Xin Na,Ya-Fei Guo,Rui Qian,Jian-Qiang Zhang,Zhen Chen,Rui Yang
1, 2-O, O-Diacetyllycorine (DALY) is one of the lycorine derivatives which has various biological properties. However, the bioavailability and clinical application of DALY was restrained because of its low water solubility and moderate antitumor activities . In order to improve its physicochemical properties, we prepared the inclusion complex of DALY with α-cyclodextrin (α-CD). The inclusion complex was characterized by UV, XRD, DSC , TG, 1 H, 2D NMR spectroscopy and its anticancer activity was evaluated in vitro against the human cell lines HCT116, A549, HepG2 and K562. The results demonstrated that DALY was encapsulated into the cavity of α-CD to form the complexes with 1:1 stoichiometry . The water solubility of DALY significantly increased for about 49 times after the inclusion complexation with α-CD. Furthermore, the cytotoxicity of DALY/α-CD against the examined cell lines was significantly increased for about 80 times compared to that of the free DALY. The improved physicochemical and biological properties of the inclusion complexes will be beneficial for its potential applications in the design and formulation of natural medicines.
研究领域:
药学
·
肿瘤学
·
天然药物化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2024
·Vol. 141
·期 32
·e55747
·
IF 2.7
Yuhang Wang,Mingyang Liu,Zhengsheng Hu,Hanlin Lv,Yanjun Chen,Yifeng Wang
As an efficient means of material carrying, multilayer capsules are widely used in medicine, agriculture, food safety and other fields. Here, we report a kind of temperature-triggered multilayer capsule with chitosan-sodium dodecyl benzene sulfonate (CS-SDBS) as the shell and gelatin bead containing α-cyclodextrin (α-CD@gelatin) as the core. The α-CD@gelatin/CS-SDBS multilayer capsules can simultaneously encapsulate various substances, such as drugs, fluorescent materials, and nanoparticles. The encapsulated substances do not interfere with each other because they are located in different layers. Both the temperature-sensitive property of gelatin and the host-guest interaction between α-CD and SDBS are utilized to achieve temperature-controlled release of substances in the multilayer capsules. The release rate can be adjusted by the α-CD amount in the gelatin beads. The controlled drug release and chemical detection of the multilayer capsules are studied with sodium salicylate, iodine, and purple cabbage pigment as the carriers. The results show that the α-CD@gelatin/CS-SDBS multilayer capsules have excellent capabilities of encapsulation and controlled release, which are beneficial for their application in the fields of substance encapsulation, drug-controlled release, and chemical detection.
研究领域:
材料科学
·
医药学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
Analytical Methods
·
2019
·Vol. 11
·期 14
·1951-1957
·
IF 2.378
Qiumin Ye,Jihong Hu,Datong Wu,Baozhu Yang,Yongxin Tao,Yong Qin,Yong Kong
Recognition of enantiomers using simple and smart devices remains a challenge in modern chemistry, and the development of advanced host materials is the key for the chiral recognition of guest enantiomers. Here, we report a novel enantioselective sensing device based on a bioactive tripeptide, glutathione (GSH). During the construction of the GSH-based enantioselective sensing device, the mercapto group (–SH) of GSH was effectively protected by α-cyclodextrin (α-CD) from being oxidized to disulfide bond (S–S). The α-CD/GSH showed an efficient recognition of tryptophan (Trp) enantiomers due to the intrinsic chiral microenvironment of GSH and the well-retained spatial configuration of GSH. The temperature sensitivity of the α-CD/GSH enantioselective sensing device is also discussed. Finally, the proposed α-CD/GSH was successfully applied in the analysis of the ratio of L- and D-Trp in non-racemic enantiomer mixtures.
研究领域:
化学
·
生物化学
✓ 已验证
产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2023
·
IF 8.6
Xi Quan,Jun Zhang,Linlin Yin,Wei Zuo,Yu Tian
In this work, novel Fe 3 O 4 @α-CD nanoparticle was synthesized for the catalytic activation of peroxymonosulfate (PMS) towards carbamazepine (CBZ) degradation. The effect of α-CD content, Fe 3 O 4 @α-CD dosage and PMS concentration on the catalyst activity were systematically evaluated. The results showed the synergistic effect between α-CD and Fe 3 O 4 can greatly improve the removal efficiency of CBZ in the Fe 3 O 4 @α-CD/PMS system. CBZ removal efficiency gained 73.37% in 5 min at pH 7.0 with PMS 1 mM, Fe 3 O 4 @α-CD load 0.4 g/L and CBZ 10 μM. The variation in the removal efficiency of different PPCPs under the same conditions mainly ascribed to the adsorption of α-CD and the activation of PMS by Fe 3 O 4 to generate free radicals, in which sulfate radical (SO 4 ·− ) and hydroxyl radicals ( · OH) was determined as the reactive species in the Fe 3 O 4 @α-CD/PMS system. Density functional theory (DFT) calculations was also utilized to optimize the structure of composite and confirmed that the charge distribution mainly concentrate on Fe 3 O 4 . As deduced from the LC-MS analysis, the possible CBZ degradation pathways were proposed. CBZ degradation efficiency still reached 54% after three cycle, which indicates that Fe 3 O 4 @α-CD catalyst has a good reusability potential and practical applications.
研究领域:
环境科学
·
材料科学
·
催化化学
✓ 已验证
DOI
高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2021
·
IF 4.759
Xinying Zheng,Yang Qin,Xiaobing Meng,Zhengyu Jin,Liuping Fan,Jinpeng Wang
In this work, we for the first time synthesized the polyethylene glycol (PEG) bonded silica gel via KH-560 as a silane coupling reagent for column chromatography by a solid/liquid surface continuous reaction method. The molecular interaction, structure, morphology, and thermostability was characterized by fourier transform infrared spectroscopy (FTIR), elemental analysis (EA), scanning electronic microscope (SEM) and thermogravimetric analysis (TGA). Given that PEG is capable to self-assemble with α-CD, the PEG bonded silica gel was used as packing of column chromatography to achieve the selective separation of α-cyclodextrin (α-CD) at room temperature and atmospheric pressure. The bonded silica gel column could realize the effective separation of α-CD in the enzymatic hydrolysis mixture, which provides support for industrial separation of α-CD.
研究领域:
化学
·
材料科学
·
分离技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING RESEARCH & DESIGN
·
2020
·
IF 3.35
Zhengzhong Zhou,Dan Li,Qigang Wu,Tao Zheng,Haoran Yuan,Na Peng
A facilitated-transport enantio-separation mechanism was proposed in this study and verified with an enantio-selective thin film composite membrane. The polysulfone membrane substrate was first fabricated at the optimized conditions, and the chiral selector α-CD was then incorporated into the selective layer by mixing with the MPD monomer for interfacial polymerization. Racemic tryptophan was employed as the model selectant, and inversed enantio-selectivities, 1.55 and 0.6 were observed from two different operation mode driven by concentration gradient and pressure gradient, respectively. The facilitated-transport separation mechanism was demonstrated by the concentration driven mode. The effects of other influencing factors including racemic feed concentration, α-CD concentration and pressure were also investigated.
研究领域:
生物化学
·
材料科学
·
分离技术
✓ 已验证
产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2017
·
IF 4.811
Taotao Xu,Junhua Li,Jun Cao,Wenxia Gao,Li Li,Bin He
Poly(pseudo)rotaxane (PPR) nanoparticles was facilely prepared using poly(ethylene glycol) (PEG) modified with protoporphyrin (PpIX) and α-cyclodextrin (α-CD) via host-guest interaction, the effect of α-CD number on the nanoparticle properties was investigated. The PEG with protoporphyrin (PEG-PpIX) end capping was synthesized via coupling reaction and the poly(pseudo)rotaxane nanoparticles with different amount of α-CD were fabricated by host-guest interaction between mPEG-PpIX and α-CDs. The final product was characterized by nuclear magnetic spectrum ( 1 H NMR), X-ray diffraction (XRD), atomic force microscope (AFM) and dynamic light scattering (DLS). The results showed that the poly(pseudo)rotaxane nanoparticles with uniform spherical shape was successfully prepared and doxorubicin (DOX) could be efficiently encapsulated in the nanoparticles. The amount of α-CDs in poly(pseudo)rotaxane nanoparticles was proportional to micellar size and drug release rate. The nanoparticles with higher α-CD number showed better anticancer efficacy in half maximal inhibitory concentration (IC 50 ) test. The cell internalization efficiency of DOX-loaded poly(pseudo)rotaxane nanoparticles could be further improved by lowering the α-CD number to receive smaller nanoparticle size.
研究领域:
生物化学
·
药学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICAL LETTERS
·
2025
·
IF 1.8
Long Chen,Jianglong Du,Xiaopeng Peng,Jiacheng Ye,Keqi Ye,Yinghua Yan,Chuan-Fan Ding
The identification and separation of isomers are of great significance due to the distinct physicochemical properties and wide-ranging applications. In this study, a simple and rapid method based on ion mobility spectrometry (IMS) was developed to distinguish and relatively quantify the 2,5/3,5-lutidine (2,5/3,5-LUT) isomers. Initially, the two isomers were separated through complexation with α-, β-, and γ-cyclodextrins (CDs), with a slight inter-peak resolution observed in the formation of the [CD+LUT+H]+ complexes. To enhance the differentiation, metal ions (Mn2+, Fe2+, Co2+, Zn2+) were introduced to form ternary complexes, and α-CD in coordination with Zn2+ yielded the most effective separation of 2,5/3,5-LUT. Theoretical conformations of [α-CD + 2,5/3,5-LUT+H]+ and [α-CD + 2,5/3,5-LUT+Zn-H]+ were optimized. Furthermore, collision-induced dissociation (CID) analysis of the [α-CD + 2,5/3,5-LUT+Zn-H]+ complexes revealed that the dissociation energy varies due to different spatial conformations. Finally, the method demonstrated reliable relative quantification, achieving a satisfactory linear correlation (R2>0.99). The developed approach offers a simple, precise, and cost-effective strategy for isomer identification and conformational analysis, with potential applications in chemical and pharmacological fields.
研究领域:
分析化学
·
药物化学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Bio Materials
·
2019
·
IF 0
Peihong Li,Chunling Zhang,Rui Li,Lijie Qu,Xueyan Dai,Yanlong Sui,Jiazi Hou
Pluronic F127 is a thermosensitive polymer that has been extensively studied and utilized in biomedicine. To improve the gelation properties of F127, α-cyclodextrin was introduced by physical interactions, such as forming inclusion complexes, hydrogen bond self-assembly, and hydrophobic interactions, to prepare F127−α-CD hydrogels. This study explored the temperature-dependent sol–gel transition behavior, gelation mechanism, interior morphology, and controlled release of the anticancer drug 5-fluorouracil. Results showed that hydrogel could be obtained at 1.0%–8.0% weight content of F127. The cross-linking points in this system were PEO−α-CD microcrystalline region and micelle with poly(propylene oxide) as the core. The network inside F127−α-CD hydrogels made it stable and conducive for controlled release. Therefore, this hydrogel is a promising drug release system.
研究领域:
药剂学
·
生物材料
✓ 已验证
产品关联
DOI
PubMed
JOURNAL OF MOLECULAR LIQUIDS
·
2022
·
IF 6.633
Ang Li,Siru Ren,Chuanjiang Teng,Hongmei Liu,Qi Zhang
Deep eutectic solvents (DESs) are emerging as potential candidates as additives/modifiers in chiral electrokinetic chromatography (EKC). However, the true role of DESs in the chiral separation process is far from being fully elucidated. Since most previous studies have been restricted to using choline chloride as the hydrogen-bond acceptor (HBA) in DESs, here we first evaluated the effect of five types of DESs (containing different HBAs) on the enantioseparation performance of an α-CD-based EKC system. The results demonstrate that these DESs are capable of moderately improving the enantioresolutions of several model drugs. A series of comparative experiments indicate that the improvement is mainly due to the contribution of the HBAs, rather than the selected hydrogen-bond donors (HBDs). Considering that most of these DESs are achiral, we further prepared five chiral DESs, aiming to investigate whether there is a synergistic effect between α-cyclodextrin and chiral DESs. However, these chiral DESs did not show obvious superiority compared with achiral DESs. This conclusion is different from the use of achiral or chiral ionic liquids (ILs) as additives in chiral EKC, in which chiral ILs usually exhibit significantly better enantioseparation performance than achiral ILs. Another important conclusion of this work is that there seems to be no significant difference between using DESs and their individual components, which is also different from the performance of most previously reported ILs. This conclusion indicates that the DESs may be virtually completely dissociated into their initial components (HBAs + HBDs) in the separation medium due to the destruction of their hydrogen-bond network. Therefore, a question which deserves particular attention of researchers in this field is raised here: whether it is absolutely necessary to use DESs in chiral EKC since adding HBAs and HBDs separately seems to have the same function?
研究领域:
分析化学
·
色谱技术
✓ 已验证
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Yue Lu,Jingnan Zhao,Guofeng Zhao,Peiyu Yi,Liyuan Duan,Huinan Sun,Qilei Liu,Qingwei Meng
Sulfur quantum dots, a new type of non-metallic quantum dots, have gained widespread attention as a promising alternative material. In this work, we synthesized aqueous sulfur quantum dots modified with α -cyclodextrin (CD-S dots) by hydrothermal method. Under visible light irradiation, CD-S dots could promote the dehydrogenative cross-coupling reaction of alcohols and amines to produce imine products. We demonstrated the host-guest interaction between the ligand of CD-S dots and benzyl alcohol through experiments such as nuclear magnetic resonance (NMR) spectroscopy. Consequently, benzyl alcohol could easily approach the surface of CD-S dots without being affected by the ligand, and then it could be oxidized by holes. It was suggested that CD-S dots reduced the barriers of carrier transfer through host-guest interactions with benzyl alcohol, and improved the selectivity and efficiency of the reaction. Our work provided ideas for the application of emerging sulfur quantum dots in selective organic synthesis. Based on the rich tunability of quantum dot materials, various efficient and eco-friendly catalytic systems are expected to be developed.
研究领域:
材料科学
·
有机化学
·
光催化技术
✓ 已验证
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2018
·
IF 4.946
Haoran Fan,Jinpeng Wang,Qingran Meng,Zhengyu Jin
In present study, monodisperse photoresponsive hollow-shell structured molecularly imprinted polymers (PHSMIPs) were fabricated based on surface imprinting technique and first proposed for selective recognition and adsorption of α-cyclodextrin (α-CD) from complex samples. The structure and the binding properties of PHSMIPs and photoresponsive surface molecularly imprinted polymers (PSMIPs) were compared. Results showed the average diameter of PHSMIPs were about 480 nm with an approximately 40 nm shell. PHSMIPs possessed BET surface areas of 273.4 m 2 /g, the pore volume of 0.333 cm 3 /g, and average pore diameters of 4.3 nm. PHSMIPs displayed higher binding capacity, better recognition ability, and faster mass transfer rate toward α-CD than PSMIPs. Furthermore, PHSMIPs was successfully used in the separation of α-CD in real reaction solution, indicating potential application for purification and selective extraction of α-CD from complex environment.
研究领域:
材料科学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）