MOLECULAR PHARMACEUTICS
·
2024
·
IF 4.5
Xudong Xie,Tiantian Sun,Heyu Pan,Dongliang Ji,Zhongyuan Xu,Ge Gao,Jiefei Miao,Lei Wang,Yanan Zhang,Ji Liu,Yong Ling,Xing Su
Chemo-photodynamic therapy is a treatment method that combines chemotherapy and photodynamic therapy and has demonstrated significant potential in cancer treatment. However, the development of chemo-photodynamic therapeutic agents with fewer side effects still poses a challenge. Herein, we designed and synthesized a novel series of β-carboline/furylmalononitrile hybrids 10a–i and evaluated their chemo-photodynamic therapeutic effects. Most of the compounds were photodynamically active and exhibited cytotoxic effects in four cancer cells. In particular, 10f possessed type-I/II photodynamic characteristics, and its 1O2 quantum yield increased by 3-fold from pH 7.4 to 4.5. Most interestingly, 10f exhibited robust antiproliferative effects by tumor-selective cytotoxicities and hypoxic-overcoming phototoxicities. In addition, 10f generated intracellular ROS and induced hepatocellular apoptosis, mitochondrial damage, and autophagy. Finally, 10f demonstrated extremely low acute toxicity (LD50 = 1415 mg/kg) and a high tumor-inhibitory rate of 80.5% through chemo-photodynamic dual therapy. Our findings may provide a promising framework for the design of new photosensitizers for chemo-photodynamic therapy.
研究领域:
药理学
·
肿瘤学
·
生物化学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF CHEMICAL RESEARCH
·
2018
·
IF 0.668
Xiaoyun Ma,Daqin He,Zhengjian Chen
A simple method for the preparation of nitriles in moderate to good yield has been achieved by treatment of aromatic and heterocyclic aldoximes with malononitrile in water at reflux in the presence of copper acetate as catalyst. Arylaldoximes with an electron-donating group showed the highest reactivity, their conversion being achievable at room temperature.
研究领域:
有机化学
·
合成化学
✓ 已验证
DOI
高影响因子
JOURNAL OF POWER SOURCES
·
2025
·
IF 7.9
Dongmei Zhang,Dingrong Long,Jiangping Zhang,Jiaxin Tu,Baoyi wang,Rubing Xu,Kunda Yang,Qianxiao Fan,Wendi Zhang,Lehao Liu,Meicheng Li
Succinonitrile (SN)-based electrolytes have emerged as promising candidates for lithium metal batteries (LMBs) due to their high ionic conductivity and thermal stability. However, the limited mechanical robustness, low reduction resistance, and residual free SN molecules can damage the electrochemical performance of batteries. Herein, an ultrathin (10 μm) yet mechanically robust composite electrolyte is developed by introducing a rigid multifunctional supporting skeleton, fabricated through in situ growth of zeolitic imidazolate framework (ZIF) nanoparticles within a three-dimensional (3D) aramid nanofibers (ANF) network. The rigid supporting skeleton functionalized with ZIF-67 nanoparticles can selectively absorb lithium salt anions to regulate Li + transport. The well-designed composite electrolyte exhibits a high Li + ionic conductivity of 3 × 10 −4 S cm −1 and a Li + transference number of 0.83 at room temperature. Meanwhile, the rigid multifunctional skeleton effectively mitigates side reactions between SN and lithium metal through inducing the formation of the LiF-rich solid electrolyte interphase layer. As a result, the composite electrolyte-based Li||Li, Li||LiFePO 4 and Li||LiNi 0.6 Co 0.2 Mn 0.2 O 2 cells show superior electrochemical performance at room temperature. Notably, the Li||LiFePO 4 cells also deliver stable performance at low temperature. This design offers an efficient, scalable fabrication method for ultrathin solid-state electrolyte-based highly stable and safe LMBs.
研究领域:
材料科学
·
电化学
·
储能技术
·
纳米复合材料
·
固态电池
✓ 已验证
产品关联
DOI
高影响因子
DYES AND PIGMENTS
·
2019
·
IF 4.018
Linfeng Chen,Xike Tian,Yong Li,Chao Yang,Liqiang Lu,Zhaoxin Zhou,Yulun Nie
Portable, rapid, accurate and on-site detection of analysis target has always been the goal of continuous efforts in the field of analysis. In this work, a novel intelligent and rapid detection system based on an AIE dye (TPA-DCV) was established for portable and on-site detection of trace water in organic solvents and CN − in water by integrating the smartphone and linear discriminant analysis (LDA). The TPA-DCV displayed remarkable solvatochromism effect and showed different fluorescence colors to different water contents of different solvents, with the minimum detection limit of 54 ppm. In addition, TPA-DCV also exhibited specific response to CN − , and showed significant fluorescence changes to different amounts of CN − . With the assist of this detection system, these different fluorescence color signals could be accurately classified in canonical score plot. What's more, the classification and distribution of fluorescence color in canonical score plot showed regular change with the target concentration, which could be used to quantify the trace water and CN − . The rationality and practicability of this detection system were preliminary verified by a large number of real sample analyses. This detection system greatly simplifies the analysis process, which is in the proof of intelligent and rapid detection just using a simple color analysis without any instrument test, which may be a big step forward.
研究领域:
分析化学
·
环境科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
RESEARCH ON CHEMICAL INTERMEDIATES
·
2015
·Vol. 41
·期 8
·5915-5927
·
IF 1.221
Li Changjiang,Xiang Kaiqiang,Liu Yunchang,Zheng Yuchuan,Pan Le,Tian Baozhu,Zhang Jinlong
4-(dicyanomethylene)-2-methyl-6-[p-(dimethylamino)-styryl]-4H-pyran (DCMS) as a colorimetric fluorescent chemodosimeter for Cu 2+ was synthesized. DCMS can selectively recognize Cu 2+ without disturbance by other metal ions in acetonitrile. Furthermore, the DCMS solution showed a distinguishable color change visible to the naked eye after addition of Cu 2+ . DCMS for Cu 2+ sensing in acetonitrile had a remarkably low detection limit of 0.2 μM, which is 1 % of the toxicity level in drinking water defined by the US Environment Protection Agency (USEPA). Interestingly, the results suggest that the Cu 2+ sensing mechanism may be involved in a redox reaction between Cu 2+ and DCMS.
研究领域:
分析化学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
TALANTA
·
2022
·
IF 6.556
Xiang-yu Kong,Shao-Min Shuang,Yue-tao Zhang,Yu Wang,Chuan Dong
A novel dicyanoisophorone-based red-emissive fluorescence probe (YT) with large Stokes shift (230 nm) was synthesized for rapid (<20 s) and selective detection of hypochlorite ions in nearly 100% aqueous medium. YT responded to hypochlorite ions via the ClO − -promoted oxidative deprotection of thioacetal , leading to a red shift in its fluorescence maximum from 590 nm to 640 nm accompanied by naked-eye color change from orange to red. The emission response of the probe toward ClO − presented a good linear relationship in the 5–160 μM concentration range, with the LOD of 4.64 μM. Further, the probe YT was successfully employed in exogenous and LPS-induced endogenous imaging of ClO − in live cells and zebrafish, demonstrating its potential applications in biological science.
研究领域:
分析化学
·
生物化学
·
生物成像
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Xiao-Chen Ma,Chun Pu,Yue-Xing Zhang,Gang-Gang Chang,Ge Tian,Si-Ming Wu,Jia-Wen Liu,Zhi-Yi Hu,Li-Ying Wang,Yi-Xia Yin,Christoph Janiak,Xiao-Yu Yang
Efficient regeneration of Pd catalysts is a challenge and has a very high technological importance. Herein, we report confined Pd clusters with the ultrafine size (1.2 nm) and ultralow loading amount (0.14 wt%) in a metal–organic framework (MOF), which could potentially allow for the successive realization of the cascade-type catalytic reaction from starting reagents to final desired products, and thus to avoid the excessive processes, save energy and reduce waste. Experiments and theoretical computations have been conducted to study the strong host–guest interaction between the Pd clusters and the MOF support, leading to the high catalytic activity and dynamic of the Pd clusters. A unique dynamic structure from active disordered arrangement to deactive crystalline arrangement and then back to the active disordered arrangement (>99% of activity after regeneration by simple H 2 reduction). The MOF-confined Pd shows excellent catalytic activity (>99% activity), selectivity (around 100%) and stability (>99% activity after recycling) under mild reaction conditions (atmospheric temperature and pressure).
研究领域:
催化
·
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
Chemical Engineering and Processing-Process Intensification
·
2023
·
IF 4.3
Qiang Liu,Jia-Ni Zhang,Ting-Liang Xie,Shi-Xiao Wei,Hao-Tian Tong,Shuang-Feng Yin
The average size and particle size distribution (PSD) of zeolitic imidazolate frameworks (ZIFs) (such as ZIF-8, ZIF-67) are closely related to their physical and chemical properties. However, it is difficult to prepare small ZIFs with narrow PSD in traditional batch reactors owing to poor mixing efficiency. Here, a four-stage oscillating feedback microreactor (FOFM) was developed to prepare ZIFs by microemulsion method. CFD simulations and visualization experiments were conducted to investigate liquid-liquid two-phase flow patterns involved, demonstrating that chaotic advection can be effectively produced, thus dispersed phase is broken up into small droplets and homogeneous microemulsions are obtained. The proposed microemulsion method based on FOFM enables preparation of ZIF-8 with small average size (38.2 nm) and narrow PSD ( σ g = 1.24) without surfactant at a flow rate of 90 mL/min.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）