Journal of Energy Storage
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2025
·
IF 9.8
Cheng Liu,Yi Zhang,Pengrui Zhang,Yigang Ding,Jinhe Sun
A multitude of composite phase change materials (PCM) systems have been developed, resulting in significant advancements in the efficiency of solar thermal storage systems. However, there is a paucity of inorganic-organic composite PCMs systems, and the phase change mechanism remains unclear, which significantly constrains the deployment and advancement of this category of PCMs. To address this gap in the literature, this team has developed a novel organic-inorganic composite PCM system using 30 wt% Mg(NO 3 ) 2 ·6H 2 O (MNH) and 70 wt% propanamide (POA) as raw materials. The thermal physical properties of the PCMs were initially analyzed, and the results demonstrated that the PCMs exhibited favourable latent heat and thermal cycling stability. The melting point was found to be 376.2 K, with a latent heat of melting of 131.93 J·g −1 . It was observed that the melting temperature and latent heat remained essentially unaltered after 500 cycles. Subsequently, the structure of the PCMs was analyzed using X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FT-IR). Ultimately, the interaction between liquid MNH and POA was modeled using molecular dynamics, allowing for a deeper understanding of the phase transition mechanism. It is hypothesized that the hydrogen bonds (HBs) between the two substances affects the physical bond, and that HBs contribute to the PCMs having good stability and a high thermal decomposition temperature. The rational mechanism of this phenomenon is explained from many aspects, including structure, Hirshfeld surface and thermal analysis. It is anticipated that the discovery of this new PCMs will facilitate large-scale applications in solar energy storage.
研究领域:
材料科学
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能源存储
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产品关联
DOI
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2020
·
IF 2.369
Huimin Liu,Shui Wang,Chao Qu,Manman Li,Yixin Qu
In this paper, the solubility of chlorpropamide (CPA) in 14 solvents including 8 alcohols (ethanol, n-propanol, isopropanol, n-butanol, 2-butanol, iso-butanol, n-pentanol, and isopentanol) and 6 acetate esters (ethyl acetate, propyl acetate, isopropyl acetate, butyl acetate, amyl acetate, and methyl propionate) at temperatures of 283.15 to 323.15 K and atmospheric pressure was determined using a laser method. The solubility as a function of temperature was regressed using modified Apelblat, Van’t Hoff, λh, Wilson, and nonrandom two-liquid (NRTL) models. On the basis of the experimental and the simulation results, the mixing properties of the solutions, that is, mixing Gibbs energy, enthalpy, and entropy, were estimated.
研究领域:
化学工程
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药物化学
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DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
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2014
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IF 4.331
Yun Cai,Zhenhua Zhang,Shanshan Jiang,Miao Yu,Caihuan Huang,Ruixia Qiu,Yueyu Zou,Qirui Zhang,Shiyi Ou,Hua Zhou,Yong Wang,Weibing Bai,Yiqun Li
This research was aimed to investigate why chlorogenic acid, presents at high concentrations in some food raw material, influences acrylamide formation. In the asparagine/glucose Maillard reaction system (pH = 6.8), addition of chlorogenic acid significantly increased acrylamide formation and inhibited its elimination. In contrast, the quinone derivative of chlorogenic acid decreased acrylamide formation. Three mechanisms may be involved for increasing acrylamide formation by chlorogenic acid. Firstly, it increased the formation of HMF, which acts as a more efficient precursor than glucose to form acrylamide. Secondly, it decreased activation energy for conversion of 3-aminopropionamide (3-APA) to acrylamide (from 173.2 to 136.6 kJ/mol), and enhances deamination from 3-APA. And thirdly, it prevented attack of the produced acrylamide from free radicals by keeping high redox potential during the Maillard reaction.
研究领域:
食品科学
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化学
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DOI
高影响因子
CRYSTAL GROWTH & DESIGN
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2022
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IF 4.01
Chunhao Liu,Yongli Wang,Yihan Zhao,Xin Li,Na Wang,Xin Huang,Ting Wang,Hongxun Hao
In an attempt to understand the relationship between solution chemistry and polymorphic nucleation, the flexible molecule chlorpropamide is used as a model compound to study its cooling crystallization behavior in four solvent systems. Online ATR-FTIR spectra proved the existence of dimers and solvated monomers in the solution. 2D nuclear overhauser effect spectroscopy and molecular dynamics simulations further revealed the molecular preassembled species in the solution. The results show that, in ethanol, ethanol/n-heptane, and ethyl acetate/n-heptane solvents, the solute molecules exist in the form of solvated monomers in multiple conformations. The stable formation of metastable form γ in ethyl acetate/n-heptane shows that, compared to conformational flexibility, the desolvation process plays a crucial role in overall self-assembly during the nucleation process. While in ethyl acetate, the solute molecules mainly exist as dimers and the rearrangement of the “wrong conformation” dimers becomes a key step to the nucleation rate and leads to the formation of stable form α. As a result, the self-association mode and conformational distribution of chlorpropamide in the solution work together to affect the nucleation process and polymorphic outcome.
研究领域:
化学
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材料科学
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DOI
高影响因子
CHINESE CHEMICAL LETTERS
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2016
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IF 1.947
Hong-Lei Xie,Chun-Chi Liu,Yi-Qun Li,Chang-Lin Bai,Chen-Zhou Hao,Jing Guo,Chang-Qun Luo,Dong-Mei Zhao,Mao-Sheng Cheng
A novel series of β -propanamide derivatives as inhibitors of cholesteryl ester transfer protein (CETP) were synthesized. Previously, H3 (IC 50 2 μmol/L) was observed to inhibit CETP moderately (Xie et al ., 2016). Structural modifications based on H3 led to discovery of the successful CETP inhibitor, known as 1-methyl-4-arylpyrazole. Using a similar approach, compound Q08 was identified as a highly potent CETP inhibitor with an IC 50 of 490 nmol/L in vitro .
研究领域:
药物化学
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生物化学
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DOI
高影响因子
Polymer Chemistry
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2020
·Vol. 11
·期 47
·7542-7550
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IF 5.342
Haoyu Liu,Sen Zhang,Xiaoyu Huang,Aishun Ding,Guolin Lu
A new acrylamide monomer consisting of both difluoromethylthio and isopropylamide moieties, N-3-(difluoromethylthio)propyl-N-(3-(isopropylamino)-3-oxopropyl)acrylamide (DFTP-NIPAM-AM), was firstly synthesized from 3-difluorothiomethyl-1-propylamine via aza-Michael addition reaction followed by amidation with acryloyl chloride. A well-defined fluoropolymer with a relatively narrow molecular weight distribution, poly(DFTP-NIPAM-AM), was obtained via reversible addition–fragmentation chain transfer (RAFT) polymerization using 3-(benzylthiocarbonothioylthio)propanoic acid as chain transfer agent. The thermal property of the poly(DFTP-NIPAM-AM) homopolymer was examined by differential scanning calorimetry (DSC), which indicated that difluoromethylthio moiety has an obvious impact on the glass transition temperature (Tg). The critical micelle concentration (cmc) of poly(DFTP-NIPAM-AM) homopolymer in aqueous solution was determined by fluorescent probe technique. It was found that poly(DFTP-NIPAM-AM) homopolymer could self-assemble into spherical micelles in aqueous solution, which was visualized by transmission electron microscopy (TEM).
研究领域:
高分子化学
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材料科学
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DOI
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
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2018
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IF 4.61
Sisheng Wu,Ting Luo,Siyu Wang,Jicong Zhou,Yingchun Ni,Zhengwei Fu,Yuanxiang Jin
Propamocarb (PM) is a widely used fungicide that affects lipid biosynthesis in fungi. In this study, we explored the effects of PM on mouse metabolism and gut microbiota-related pathways by exposing C57BL/6J mice to 1, 3, and 10 mg/L PM through drinking water for a duration of 10 weeks. We found that hepatic bile acids (BAs) were considerably increased in the PM-treated group. The transcription of genes related to BA synthesis and transportation were also markedly altered in the liver and the ileum; accordingly, serous BA profiles were changed. BAs are tightly associated with energy metabolism and the gut microbiota; as expected, we observed that hepatic glycolysis; β-oxidation; fatty acid transportation, release and synthesis; and triacylglycerol synthesis and transportation were significantly altered at the transcriptional level. Gut microbial community structures were significantly changed both in cecal contents and feces. Using Linear discriminant analysis Effect Size (LEfSe), we found that Chloroflexi, Bacteroidetes and Actinobacteria phyla; Prevotellaceae, Odoribacteraceae and Porphyromonadaceae families; and Butyricimonas, Oscillospira, Parabacteroides, Prevotella and Dorea genera enriched in PM-treated mice. Fecal metabolites involved in energy metabolism were likewise altered. In addition, the atherosclerosis-promoting molecule trimethylamine was significantly increased in feces, which induced a disturbance in the cardiac NO/NOS pathway and an increase in NF-κB transcriptional levels. Our findings indicated that chronic PM exposure induced disorders in enterohepatic metabolism and had potential to increase the risk of cardiovascular disease.
研究领域:
毒理学
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代谢组学
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微生物组研究
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分子生物学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
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2018
·Vol. 135
·期 22
·46266
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IF 1.901
Jing Wu,Ming Li,Aili Zhang
A terpolymer comprising of sodium styrene sulfonate (SSS), n -methylol acrylamide (HAM), and acrylic acid (AA) was synthesized by aqueous free radical copolymerization and evaluated as fluid loss additive (FLA) in oil well cement. In this article, HAM is first introduced in the preparation of FLA as an environment-friendly monomer, which effectively improves the adhesion and fluid loss control of the terpolymer. The experimental synthesis conditions were optimized by orthogonal experiments. The molecule weight of the terpolymer was determined by gel permeation chromatography. The molecule structure of the synthesized terpolymer was verified by X-ray photoelectron spectroscopy and Fourier transformer infrared spectrum. The thermal stability of the synthesized terpolymer was tested by thermogravimetry (TG). The structure of the terpolymer aqueous solution was observed by scanning electron microscope. The results show that SSS/HAM/AA has an excellent thermal resistant. The thermal degradation is not obvious before 295.2 °C. Furthermore, the microstructure of SSS/HAM/AA in water conducive to good fluid loss control ability. When the dosage of SSS/HAM/AA is up to 2.0% in fresh water cement slurry, the filtration loss [FL (HTHP) ] can be controlled within 50 mL at 90–150 °C. SSS/HAM/AA has an excellent property of reducing filtration loss. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018 , 135 , 46266.
研究领域:
材料科学
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化学工程
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产品关联
DOI
高影响因子
MOLECULES
·
2017
·Vol. 22
·期 6
·888
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IF 2.861
Zhiyong Xiong,Bing Li,Lin Li,Liting Wan,Xiaolong Peng,Yongpo Yin
The effect of four mercapto flavor compounds (1,2-ethanedithiol, 1-butanethiol, 2-methyl-3-furanthiol, and 2-furanmethanethiol) on acrylamide elimination were investigated in model systems. The obtained results showed that mercaptans assayed were effective in elimination arylamide in a model system. Their reactivities for decreasing acrylamide content depended on mercaptan’s molecular structure and acrylamide disappearance decreased in the following order: 1,2-ethanedithiol > 2-methyl-3-furanthiol > 1-butanethiol > 2-furanmethanethiol. Mercaptans were added to acrylamide to produce the corresponding 3-(alkylthio) propionamides. This reaction was irreversible and only trace amounts of acrylamide were formed by thermal heating of 3-(alkylthio) propanamide. Although a large amount disappeared, only part of the acrylamide conversed into 3-(alkylthio) propionamides. All of these results constitute a fundamental proof of the complexity of the reactions involved in the removal of free acrylamide in foods. This implies mercapto flavor/aroma may directly or indirectly reduce the level of acrylamide in food processing. This study could be regarded as a pioneer contribution on acrylamide elimination in a model system by the addition of mercapto flavor compounds.Keywords:acrylamide;3-(alkylthio) propionamides;mercaptan;mercapto flavors;Michael addition
研究领域:
食品科学
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化学
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DOI
PubMed
高影响因子
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
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2019
·Vol. 393
·期 6
·967-978
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IF 2.058
Rong Rong,Zhang Rui-zhen,Wang Xin,Dan Yu-han,Zhao Yun-li,Yu Zhi-guo
R -/ S -2-(2-hydroxypropanamido) benzoic acid ( R -/ S -HPABA), marine-derived anti-inflammatory antiplatelet drugs, were initially synthesised in our group. However, preliminary research showed that R -/ S -HPABA were eliminated rapidly because of extensive hydroxylation metabolism of phenyl ring in vivo. In order to reduce significant hydroxylation metabolism to improve pharmacological activity and bioavailability, trifluoromethyl group was incorporated into R -/ S -HPABA to synthesise R -/ S -2-(2-hydroxypropanamido)-5-trifluoromethyl benzoic acid ( R -/ S -HFBA), respectively. The purposes of this study were to report the synthesis of R -/ S -HFBA and compare the anti-inflammatory antiplatelet effect and pharmacokinetic properties of R -/ S -HFBA with those of R -/ S -HPABA. Carrageenan-induced rat paw edema assay was used for the evaluation of the anti-inflammatory activity. R -/ S -HFBA showed better results in inhibiting edema and were able to prolong the anti-inflammatory effect after carrageenan injection. The antiplatelet aggregation activity of R -/ S -HFBA and R -/ S -HPABA was studied on arachidonic acid-induced platelet aggregation of rabbit platelet-rich plasma. The aggregation inhibition rate of R- / S -HFBA was significantly ( p < 0.05) higher than that of R- / S -HPABA, respectively. Molecular docking study revealed that R -/ S -HFBA possess more potent binding affinity with COX-1/COX-2 than R -/ S -HPABA, respectively, and that the presence of trifluoromethyl group leads to increase in activity of R -/ S -HFBA. R -/ S -HFBA also afford more favorable pharmacokinetic properties than R- / S -HPABA, respectively, such as higher C max , larger AUC 0-∞ , and longer t 1/2 , which, as expected, are more metabolically stable.
研究领域:
药理学
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药物化学
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药物设计
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MOLECULAR PHARMACEUTICS
·
2014
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IF 4.787
Yanping Li,Yangyang Zhou,Bowen Qi,Tao Gong,Xun Sun,Yao Fu,Zhirong Zhang
Parkinson’s disease (PD) has become one of the most deadly diseases due to a lack of effective treatment. Herein, N-3,4-bis(pivaloyloxy)dopamine-3-(dimethylamino)propanamide (PDDP), a brain-specific derivative of dopamine, was designed and synthesized, which consists of a brain targeted ligand, N,N-dimethyl amino group, and two dipivaloyloxy groups for lipophilic modification. PDDP was investigated both in vitro and in vivo by comparing with L-DOPA and another derivative (BPD) without N,N-dimethyl amino group. PDDP showed a more pronounced accumulation in mouse brain microvascular endothelial cells (bEnd.3) than BPD via an active transport process. The increased cellular uptake of PDDP was proven to be mediated by putative pyrilamine cationic transporters. Following intravenous administration, the concentration of PDDP in the brain was 269.28-fold and 6.41-fold higher than that of L-DOPA and BPD at 5 min, respectively. Additionally, PDDP effectively attenuated the striatum lesion caused by 6-hydroxydopamine (6-OHDA) in rats. More importantly, PDDP presented antioxidant and antiapoptotic effects on 6-OHDA-induced toxicity in human neuroblastoma cells (SH-SY5Y). Thus, N,N-dimethyl amino group-based PDDP represents an effective and safe treatment for PD.
研究领域:
神经科学
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药理学
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药物递送系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
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2014
·
IF 0.968
Mei-Yun Zhou,Zhao-Jun Wu,Wen-Qing Li,Xing-Peng Hu,Rian Yan,Shi-Yi Ou,Hua Zhou
(R)-3-(allylthio)-2-((R)-3-(allylthio)-2-aminopropanamido)propanoic acid was isolated from the bulb of garlic, together with four known amino acids. Its structure was elucidated on the basis of 2D NMR and MS techniques. To the best of our knowledge, (R)-3-(allylthio)-2-((R)-3-(allylthio)-2-aminopropanamido)propanoic acid, which showed antibacterial activity against the Staphylococcus aureus antibiotic resistant strain, was the first example of dipeptide from garlic.
研究领域:
化学
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药理学
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微生物学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）