SENSORS AND ACTUATORS A-PHYSICAL
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2022
·
IF 4.291
Bin Zhou,Yu Chen,Kun Hu,Shah Fahad,Yu-xuan Zhou,Yi-ming Yuan,Min Wang
Flexible pressure sensor array has attracted much attention in wearable electronics , but still lacks self-power, high resolution, large-area fabrication, and low crosstalk . Herein, we present a self-powered pressure sensor array via patterned piezoelectric polyvinylidene fluoride-trifluoroethylene (PVDF-TrFE) nanofibrous. The PVDF-TrFE nanofibers were collected by patterned metal ground electrodes that isolated each piezoelectric cell. The isolated sensing cells can effectively reduce the crosstalk caused by additional deformation. The potential from individual cell is detected through the row+column electrode configuration to determine the corresponding pressure point and trajectory information. The as-fabricated pressure sensor array showed an excellent linear piezoelectric response (2.5 mV/kPa), a fast response time (5 ms), and good repeatability (25,000 cycles). Furthermore, our piezoelectric devices with constructed PVDF-TrFE layer are feasible in scaling up to a large-area sensor array. Accurate recognitions of the letter "h" trajectory tracking and tactile sensation by our self-powered tactile sensor array show potential applications in electronic skin and artificial intelligence.
研究领域:
材料科学
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电子工程
✓ 已验证
产品关联
DOI
高影响因子
Nanoscale
·
2023
·Vol. 16
·期 3
·1102-1114
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IF 6.7
Song He,Xingyu Yu,Juanjuan Wang,WenKang Zhong,Baochang Cheng,Jie Zhao
Emerging resistive switching devices hold the potential to realize densely packed passive nanocrossbar arrays, suitable for deployment as random access memory devices (ReRAMs) in both embedded and high-capacity storage applications. In this study, we have engineered ReRAMs comprising ITO/(UVO-treated) amorphous ZnO (a-ZnO)/MAPbI3/Ag which effectively mitigate cross-talk currents without additional components. Significantly, we successfully executed a comprehensive set of 12 distinct 2-input sequential logic functions in a single halide perovskite ReRAM unit for the first time. Furthermore, these logic functions are devoid of any dependency on external light sources, entail merely 1 or 2 logic steps, and showcase symmetrical operability. A superior resistive switching behavior was achieved by harmonizing the charge transport within the bulk MAPbI3 and the tunneling barriers at the interfaces. The outcomes indicate progress in mitigating cross-talk and executing multiple logic functions within a single halide perovskite ReRAM unit, offering a new perspective for the advancement of halide perovskite ReRAMs.
研究领域:
材料科学
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电子工程
✓ 已验证
DOI
高影响因子
Science Advances
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2025
·Vol. 11
·期 19
·
IF 12.5
Wen-Hao Han,Feng-Bin Zhang,Shun-Xia Ji,Kai-Lu Liang,Jun-Xia Wang,Xiao-Ping Fan,Shu-Sheng Liu,Xiao-Wei Wang
According to the plant vigor hypothesis, younger, more vigorous plants tend to be more susceptible to herbivores compared to older, mature plants, yet the molecular mechanisms underlying this dynamic remain elusive. Here, we uncover a hormonal cross-talk framework that orchestrates the age-related balance between plant growth and herbivore defense. We demonstrate that the accumulation of salicylic acid (SA), synthesized by Nicotiana benthamiana phenylalanine ammonia-lyase 6 (NbPAL6), dictates insect resistance in adult plants. NbPAL6 expression is driven by the key transcription factor, NbMYB42, which is regulated by two interacting auxin response factors, NbARF18La/b. In juvenile plants, higher auxin levels activate NbmiR160c, a microRNA that simultaneously silences NbARF18La/b, subsequently reducing NbMYB42 expression, lowering SA accumulation, and thus weakening herbivore defense. Excessive SA in juvenile plants enhances defense but antagonizes auxin signaling, impairing early growth. Our findings suggest a seesaw-like model that balances growth and defense depending on the plant’s developmental stage.
研究领域:
植物学
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分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2025
·
IF 9.7
Zhe-Jian Yi,Xiao-Yue Chen,Jia-Zhen Zhao,Yi-Ming Xie,Ji-Huai Wu,Zhang Lan,Fu-Da Yu,Lan-Fang Que,Hao Luo
Zn||V 2 O 5 full cell exhibit excellent low-temperature performance in Zn(ClO 4 ) 2 based electrolytes due to the strong hydrogen bond breaking effect. However, the crosstalk effect between the V 2 O 5 cathode and Zn anode at room temperature leads to continuous side reactions, highly limiting their practical application. Herein, a water deactivation strategy by introducing methanol additive has been proposed and its effect mechanism on the crosstalk has been explored. It is found that the methanol additive is conducive to build a water-poor solvation structure and reduce the activity of free water, inhibiting the corrosion and improving the cycle stability of Zn anode. In addition, methanol additive triggers the reversible cycling of inert Zn 3 (OH) 2 (V 2 O 7 )(H 2 O) 2 , and suppress its deposition on Zn anode, then breaking the electrochemical crosstalk problem of the Zn||V 2 O 5 system. As expected, the Zn||V 2 O 5 full cell at the designed electrolyte demonstrates superior performance at room and low temperature, delivering a high specific capacity of 300 mAh g −1 at 25 °C, and operating stably for 7500 (>2000 h) cycles without capacity loss at −20 °C, which are superior to most reported works. This work might provide new ideas for addressing electrochemical crosstalk and constructing advanced batteries with superior temperature adaptability.
研究领域:
材料科学
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电化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Omega
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2025
·
IF 4.3
Shuai Wen,Ruipeng Zhang,Yahui Zhao,Xinyue Xu,Shaobo Ji
Electrophysiological sensors (electrodes) are used to collect complex electrophysiological signals, providing extensive information about the body’s condition. Reliable signal acquisition necessitates stable skin–electrode interfaces to prevent adverse effects arising from interface variations. Although the incorporation of conductive adhesive layers can improve the stability of these interfaces, in array electrodes, the layer may also cause short circuits and signal crosstalk. Here, we propose a general strategy for patterning the adhesive layer of array electrodes based on electrochemically grafted adhesive polymers (EGAPs). Utilizing the conductivity differences between the sensing sites and the substrate material of flexible electrodes, spatial selective loading of adhesive and ionically conductive polymers can be achieved through in situ electrochemical reactions, thus realizing spontaneous patterning. This EGAP-based method allows for a rapid and selective electrode surface modification in just two steps. Furthermore, array electrodes with EGAP acquired stable electrophysiological signals while improving the stability of the skin–electrode interface and the quality of signal collected and effectively avoided signal crosstalk between arrayed sensing sites.
研究领域:
生物医学工程
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Nano
·
2025
·
IF 16
Qing Zheng,Yifan Gao,Mengxiao Han,Yusong Wang,Hanghang Liu,Guozhi Cao,Tingting Wang,Hao Zhang,Zhen Li
Microglia usually phagocytose excessive α-synuclein (α-syn) aggregates and turn into diseased analogues in Parkinson’s disease (PD), which can present α-syn-associated antigens, secrete cytokines and chemokines to recruit peripheral immune cells, and form strong immune crosstalk to aggravate PD progression. Hence, targeting the diseased microglia and inhibiting their immune crosstalk emerge as promising strategies for PD therapy. Herein, we reprogram the diseased microglia to efficiently degrade α-syn aggregates and neutralize neuroinflammatory factors to reduce the detrimental immune crosstalk and enhance therapeutic efficacy using rationally designed core–shell IHM nanoparticles, which consist of a ligustilide-functionalized Cu2-xSe nanoparticle (CSL NP) core and a hybrid cell membrane shell. The CSL NPs can redress the diseased microglia to reduce over-presented antigens by dual roles of reducing microglial RAGE-mediated phagocytosis of α-syn aggregates and increasing the microglial mature cathepsin D (m-CTSD) to efficiently degrade α-syn aggregates. The hybrid cell membrane shell is formed by a MES23.5 cell membrane (MCM) and IFN-γ-treated RAW264.7 cell membrane (IRCM). It can not only target diseased microglia by the specific interactions between VCAM-1 on the MCM and α4β1 integrin on the microglial membrane but also absorb and reduce the secretion of neuroinflammatory factors by diseased microglia through upregulated neuroinflammatory cytokine receptors such as IL1R1, TNFR1, and CCR2 on the surface of IRCM. The biomimetic core–shell IHM nanoparticles can be effectively delivered into the brain via meningeal lymphatic vessels to modulate the diseased microglia for boosting PD therapy. Our study demonstrates the promise of targeting diseased microglia to reduce their immune crosstalk in the treatment of PD and other neurodegenerative diseases.
研究领域:
神经科学
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免疫学
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药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
·
2025
·
IF 6.1
Jingyi Ren,Longfei Li,Ziyi Wang,Siqi Zhu,Huanting Pei,Yadong Zhang,Bowen Yin,Zhenao Zhang,Xiaoya Sun,Huicai Guo,Yuxia Ma
Background Perfluorooctane sulfonate (PFOS) is a prototypical persistent organic pollutant that has been linked to liver inflammation. Sesamin (Ses), a major lignan in sesame, has been shown to exhibit health-promoting properties. However, the role and specific mechanism of Ses in PFOS-induced liver inflammation remain largely unclear. Purpose This study aimed to investigate the hepatoprotection and potential mechanism of Ses against PFOS-induced inflammation. Methods Wild-type (WT), Mincle knockout (Ko-mincle), and Hepatocyte-specific knockout Foxo1 (Hko-Foxo1) mice were intragastrically administered Ses and/or PFOS (10 mg/kg) for 4 weeks. In vitro, HepG2 cells were pretreated with Ses for 1 h, then exposed to PFOS for 24 h to establish a cell injury model. Results We revealed that Ses markedly alleviated PFOS-induced liver injury and inflammation, as evidenced by noticeable histopathological improvements, increased cell activity, and alterations in serum liver enzyme and inflammatory factor levels. Moreover, Ses pretreatment reduced the expression of Mincle and the phosphorylation of its downstream targets, SYK and p65, in macrophages. The reducing effect of Ses on liver inflammation in wild-type mice is significantly better than that in Mincle knockout mice. We also found that Ses decreased the expression of spliceosome-associated protein 130 (SAP130) and Foxo1. Further experiments revealed that SAP130 may serve as a mediator between hepatocytes and macrophages. Hepatocyte-specific knockout Foxo1 reduced the release of SAP130 from hepatocytes and inhibited Mincle/Syk signaling activation in macrophages. Conclusion This study demonstrates that Ses protects against PFOS-induced liver inflammation in mice by modulating crosstalk between hepatocytes and macrophages. Those findings support the potential of Ses as a promising natural compound for counteracting liver inflammation.
研究领域:
毒理学
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免疫学
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药理学
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环境科学
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分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MATERIALS & DESIGN
·
2023
·
IF 8.4
Shuheng Dong,Dedong Guo,Qingzhou Wang,Huixin Yu,Qing Xu,Ho-Kun Sung,Zhao Yao,Yuanyue Li,Yang Li
Flexible pressure sensors have found widespread application in medical diagnosis and human–computer interaction. These practical applications often require large-area pressure sensing arrays (PSAs) to explore spatial pressure distributions. However, the development of high-performance PSAs still presents significant challenges. Here, a new method is proposed for the fabrication of a high-resolution capacitive PSA in a 10 × 10 configuration. The array comprises the upper and lower electrode arrays of laser-induced graphene patterned on polyimide films, as well as the sandwiched dielectric units based on electrospun nanofiber membranes of H 3 PO 4 @PVPP (cross-linked polyvinyl pyrrolidone). Experimental results indicate that the PSA exhibits high sensitivity across a wide pressure range (0–200 kPa), while offering a rapid response/recovery time of 24/41 ms (at 1 kPa), an exceptionally low detection limit of ∼1.2 Pa, and a good stability of 4000 cycles. Moreover, the crosstalk of the PSA was found to be as low as 1.3%. By employing the PSA in conjunction with a convolutional neural network algorithm, a human foot-arch diagnostic system was developed for accurate detection and quantification of the plantar pressure for different types of foot arches. Such technology has significant potential in clinical detection and disease diagnosis of human foot.
研究领域:
生物医学工程
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
Device
·
2023
·
IF 0
Chang Gu,Yan Yan,Jiale He,Donglin Pu,Linsen Chen,Yu-Mo Zhang,Sean Xiao-An Zhang
Transparent non-emissive displays are ideal for augmented reality (AR) applications due to their ability to modulate ambient light as colored and transparent pixels. Electrochromic (EC) displays with transparent “ON” and “OFF” states can help enable such a display. However, unwanted image diffusion and signal crosstalk due to the imbalance between performance and the preparation process limit their practical application. In this work, we present a transparent and energy-efficient EC display prototype (4.2 inch, 16 × 16 pixels). We minimize the signal crosstalk problem by exploiting the confinement effect between EC pixels using the in situ photolithography of EC materials with the application of a photolithographic pixel definition layer and digital dispensing printing. The prototype has an optical modulation of ∼60%, a full-contrast lifetime tested beyond 20,000 cycles, an ultra-low power consumption (9.5 μW/cm 2 ), and the ability to provide spatiotemporally tunable information for potential AR applications.
研究领域:
材料科学
·
显示技术
·
光学工程
✓ 已验证
DOI
ADVANCED MATERIALS
·
2024
·
IF 27.4
Xuwen Li,Qin Guo,Qinjun Chen,Yongchao Chu,Yiwen Zhang,Hongyi Chen,Zhenhao Zhao,Yu Wang,Yifan Luo,Chufeng Li,Haoyu You,Haolin Song,Boyu Su,Kiyumars Jalili,Tao Sun,Chen Jiang
Targeting the competitive–cooperative relationships among tumor cells and various immune cells can efficiently reverse the immune-dysfunction microenvironment to boost the immunotherapies for the triple-negative breast cancer treatment. Hence, a bacterial outer membrane vesicle-based nanocomplex is designed for specifically targeting malignant cells and immune cells to reconcile the relationships based on metabolic-immune crosstalk. By uniquely utilizing the property of charge-reversal polymers to realize function separation, the nanocomplexes could synergistically regulate tumor cells and immune cells. This approach could reshape the immunosuppressive competition–cooperation pattern into one that is immune-responsive, showcasing significant potential for inducing tumor remission in TNBC models.
研究领域:
肿瘤学
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免疫学
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纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
IEEE ELECTRON DEVICE LETTERS
·
2023
·Vol. 44
·期 3
·516-519
·
IF 4.9
Weihao Zheng,Yunlong Zhao,Hongcheng Xu,Yangbo Yuan,Weidong Wang,Libo Gao
Soft piezocapacitive sensor, owing to its simple assembly and low power consumption, draws intensive interests for physiological monitoring. However, crosstalk between proximity sensing units and limited mechanically stretching suppressed its practical application for conventional capacitive sensor array. Here we report a stretchable iontronic pressure sensor (SIPS) array with low proximate crosstalk for epidermal monitoring. Benefiting from electric double layer (EDL) capacitance effect between robust aramid nanofiber (ANF) /MXene (Ti3C2Tx) composite electrode and ionic film, the SIPS exhibits a high sensitivity up to 521.69 kPa−1, low limit of detection (0.22 Pa), broad linear sensing range (200 kPa) and rapid response time (17 ms) as well as long-term stable working durability for 10,000 cycles. The serpentine island bridge structure enables the SIPS array to stretch up to 40%, allowing pulse and grip monitoring of a bent wrist and finger, respectively, through processing circuits. This demonstrates the promising application prospects in vital physiological monitoring.
研究领域:
生物医学工程
·
材料科学
✓ 已验证
DOI
高影响因子
Biotechnology Journal
·
2023
·Vol. 19
·期 1
·2300190
·
IF 4.7
Tangan Li,Chujun Zheng,Hao Xu,Qihong Ning,Qingwen Sun,Ruoyao Yu,Daxiang Cui,Kan Wang
Frequency-mixing technology has been widely used to precisely identify magnetic nanoparticles in applications of quantitative biomedical detection in recent years. Examples include immune adsorption, lateral flow assays (LFAs), and biomagnetic imaging. However, the signals of magnetic response generated by adjacent magnetic samples interfere with each other owing to the small spacing between them in applications involving multi-sample detection (such as the LFA and multiplexing detection). Such signal interference prevents the biosensor from obtaining characteristic peaks related to the concentration of adjacent biomarkers from the magnetic response signals. Mathematical and physical models of the structure of sensors based on frequency-mixing techniques were developed. The theoretical model was verified and its key parameters were optimized by using simulations. A new frequency-mixing magnetic sensor structure was then designed and developed based on the model, and the key technical problem of signal crosstalk between adjacent samples was structurally solved. Finally, standard cards with stable magnetic properties were used to evaluate the performance of the sensor, and strips of the gastrin-17 (G-17) LFA were used to evaluate its potential for use in clinical applications. The results show that the minimum spacing between samples required by the optimized sensor to accurately identify them was only about 4–5 mm, and the minimum detectable concentration of G-17 was 11 pg mL −1 . This is a significant reduction in the required spacing between samples for multiplexing detection. The optimized sensor also has the potential for use in multi-channel synchronous signal acquisition, and can be used to detect synchronous magnetic signals in vivo.
研究领域:
生物医学工程
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传感器技术
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诊断学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）