SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2021
·
IF 4.098
Qin Wang,Li-Bing Lü,Zhu Tao,Tao Sun,Qing Tang,Ying Huang
In the present work, we have investigated the effect of pH and mercury ions on the host–guest complex formed between cucurbit[7]uril (Q[7]) and Hoechst 33342 (H33342). 1 H NMR, UV–vis and fluorescence spectroscopy revealed that acid/base stimulation could change the binding stoichiometry between Q[7] and H33342. The results suggest that two complexation equilibria (1:1 and 2:1) may exist between H33342 and Q[7] at pH 2.0 and 4.5, respectively. However, a 1:1 host–guest complex was formed between H33342 and Q[7] at pH 7.0 and 10.0. Q[7] shows differential affinities for the protonated and neutral forms of H33342 dye. Moreover, the switching between H33342∙2H + @2Q[7](1:2) at pH 4.5 and H33342∙H + @Q[7](1:1) at pH 7.0 was reversible. Furthermore, as a metal stimulus, Hg 2+ ions could push (i) Q[7] from the piperazine ring to the benzimidazole position with a 1:1 guest–host ratio and (ii) a second Q[7] onto the ethyl position with a 1:2 guest–host stoichiometry. This stimulus response system will have potential applications in the field of molecular switch design.
研究领域:
超分子化学
·
分析化学
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DOI
PubMed
高影响因子
ChemPlusChem
·
2020
·Vol. 85
·期 4
·679-683
·
IF 2.753
Shengke Li,Kit Ieng Kuok,Xia Ji,Anni Xu,Hang Yin,Jun Zheng,Huaping Tan,Ruibing Wang
Graphical Antibacterial switch : The capability of cucurbit[7]uril (CB[7]) in modulating the antibacterial activity of ambroxol hydrochloride (ABX) was successfully demonstrated by using two strains of Pseudomonas aeruginosa and Escherichia coli . The antibacterial activity of ABX was “turned off” upon encapsulation by CB[7] and “turned on” after ABX was released from the CB[7]-ABX host–guest complex upon addition of a competitive guest amantadine hydrochloride. Supramolecular encapsulation by cucurbit[7]uril (CB[7]) was recently demonstrated to provide a simple and efficient method for antibacterial activity regulation of antibiotics. In this work, CB[7] was shown to form binary host-guest complex with ambroxol hydrochloride (ABX), a clinical mucokinetic and expectorant drug, which was reported to exhibit certain antibacterial activity. 1 H NMR titration and isothermal titration calorimetry experiment results suggested that the 4-hydroxyl cyclohexylamine group of ABX was included inside the CB[7] cavity, with a binding constant K a of (6.69±0.11)×10 5 M −1 in phosphate buffered saline (PBS) solution, thermodynamically driven by both enthalpy change (ΔH=−12.2 kJ/mol) and entropy change (TΔS=21.1 kJ/mol). More importantly, ABX's inhibitory activity (MIC 50 ) against bacillary strains towards Pseudomonas aeruginosa and Escherichia coli strains was decreased from (5.11±0.31)×10 −6 M −1 and (2.63±0.34)×10 −5 M −1 to zero upon encapsulation by CB[7], and was subsequently recovered to almost its original activity when a competitive guest, amantadine hydrochloride, for disassembling CB[7]-ABX complex, was added, suggesting that the antibacterial activity of ABX could be readily “turned off/on” upon its complexation and decomplexation with CB[7].
研究领域:
药理学
·
微生物学
·
化学
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DOI
高影响因子
DYES AND PIGMENTS
·
2025
·
IF 4.2
Xin Lin,Fang-Fang Shen,Ren-Jie Song
In this study, two novel fluorescent probes, H 1 /G and H 2 /G, were constructed using two alkyl-substituted cucurbit[6]urils (CB[6]s), H 1 and H 2 , and a cationic dye guest, G. The G molecules were encapsulated within the cavities of CB[6] hosts, forming 1:1 host–guest complexes. While free G molecules exhibited negligible fluorescence in solution, the inclusion complexes demonstrated a strong fluorescence signal (618 nm). The detection limits for glutamic acid (Glu) recognition by the two probes were as low as 2.98 × 10 −7 M and 4.20 × 10 −7 M, respectively. Notably, although the two modified CB[6]s differed by only a single substituent, their resulting probes demonstrated different degrees of amino acid recognition ability. The H 2 /G probe was capable of recognizing both Glu and lysine (Lys), while the H 1 /G probe detected only Glu. By employing structurally modified CB[6]s as hosts and constructing CB[6]-based fluorescent probes capable of selectively recognizing non-aromatic amino acids, this study paves the way for the biological applications of CB[6]-based supramolecular host–guest systems.
研究领域:
超分子化学
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分析化学
·
生物有机化学
·
荧光传感
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产品关联
DOI
高影响因子
Science China-Chemistry
·
2024
·Vol. 67
·期 10
·3283-3290
·
IF 10.4
Fan Peng,Cai Li-Xuan,Duan Xiao-Fang,Yin Fan,Li Chen-Chen,Deng Zhong-Hua,Li Xiao-Zhen,Sun Qing-Fu
Chiral hybrid metal halides with high photoluminescence quantum yield (PLQY) and superior dissymmetry factor ( g lum ) are promising candidates for circularly polarized luminescence (CPL) emitting sources. However, it is a great challenge to achieve both high g lum and large PLQY. Here, we report a new supramolecular strategy to fabricate chiral hybrid Cu(I)-halides with near-unity quantum yields and intense CPL emissions. The dissymmetry factor can be dramatically modulated by tuning the host-guest complexations. Attributing to the chirality and variable conformations of the host-guest complexes, a series of chiral [G@L R/S ] 2 Cu 4 I 6 have been prepared. The incorporation of different cations within the chiral L R/S hosts leads to variations of packing modes along the c -axis and different extent of distortions in the [Cu 4 I 6 ] 2− polyhedra. Among them, [H 3 O@L R/S ] + cations are stacked based on Van der Waals interactions and hierarchically self-assemble into a right/left-handed helix in [H 3 O@L R/S ] 2 Cu 4 I 6 , which results in a high g lum of −7×10 −3 and a large PLQY of 96.92%. Notably, [G@L R/S ] 2 Cu 4 I 6 shows promising applications in single-component white light emitting diodes (WLEDs), exhibiting a maximum dissymmetry factor of −1.2×10 −3 . The effective host-guest complexation and oriented hierarchical self-assembly provide an effective strategy for the development of high-performance CPL materials.
研究领域:
材料科学
·
光学
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产品关联
DOI
高影响因子
Soft Matter
·
2018
·Vol. 14
·期 21
·4231-4237
·
IF 3.709
Dahua Li,Yuzhi Xing,Lan Ding,Chengfeng Wu,Guangliang Hou,Bo Song
3-Hydroxyflavone derivatives have great potential as fluorescent probes for bio-labeling in aqueous medium. They were extensively studied in various organic solvents for the “excited state intramolecular proton transfer” process, but seldom addressed in aqueous solution due to the poor water solubility. Herein, an amphiphilic molecule bearing 3-hydroxyflavone and oligo(ethylene oxide) (denoted as 3HF-EO) was designed and synthesized. Different from the fluorescence in organic solvents, 3HF-EO in aqueous solution showed a remarkable single fluorescence emission, which is ascribed to the fluorescence of its anionic species. We found that the fluorescence intensity could be efficiently tuned via host–guest complexation. α-CD has little effect on the emission, while β-CD and γ-CD lead to enhanced and reduced emissions of 3HF-EO, respectively. The 1H NMR and 2D NOESY NMR spectra indicate that α-CD barely had any interaction with 3HF-EO, while β-CD and γ-CD formed complexes with one and two 3HF-EO molecules, respectively. These results provide a sound explanation for the modulated fluorescence intensity.
研究领域:
有机化学
·
生物化学
·
荧光探针设计
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DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2021
·
IF 4.539
Liang Xiao Gan,Chun Ling Hao,Xiao Ming Jiang
The adsorption and desorption of surfactants play an important role in the industrial processes. We used cucurbituril (Q[7]) to tune the adsorption and desorption of a cationic surfactant at quartz. The cationic surfactant, N-Benzyl-N-hexadecyl dimethylammonium halide , can spontaneously absorb on the quartz surface. But when the absorbed surfactant at quartz reacts with Q[7] to form the host-guest complex, the absorbed surfactant is desorbed from the quartz surface. Adamantanamine hydrochloride was selected as another stronger guest molecule. Owing to the higher binding constant , Q[7] preferentially complex adamantanamine. Therefore, the surfactant molecules in the cavity of Q[7] are expelled to the water–quartz interface and absorb again on the quartz surface. In this manner, the adsorption and desorption of the cationic surfactant can be modulated. Through the measurements of the surface activity, contact angle and Zeta potential , we studied the adsorption and desorption of the cationic surfactant at quartz. The real-time adsorption and desorption of the cationic surfactant were monitored by the quartz crystal microbalance with dissipation (QCM-D). The surfactant aggregates on the quartz surfaces were scanned by the atomic force microscope (AFM). We expect to provide a way of tuning the adsorption and desorption of surfactants on solid surfaces .
研究领域:
界面科学
·
化学
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DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2023
·
IF 4.4
Xing-Xing Chen,Shu-Zhen Huang,Ru-Pei Yang,Ying Huang,Qing Tang
A supramolecular fluorescent probe based on a host–guest complex has been developed for amino acid recognition and detection in aqueous solution. Cucurbit[7]uril (Q[7]) with 4-(4-dimethylamino-styrene) quinoline (DSQ) formed a fluorescent probe (DSQ@Q[7]). The DSQ@Q[7] fluorescent probe nearly generated changes in fluorescence in response to four amino acids (arginine, histidine, phenylalanine and tryptophan). These changes were attributed to the host–guest interaction between DSQ@Q[7] and amino acids, which occurred as a consequence of the subtle cooperation of ionic dipole and hydrogen bonding. Linear discriminant analysis showed that the fluorescent probe could recognize and distinguish four amino acids, and a mixture with different concentration ratios could be well categorized in ultrapure water and tap water.
研究领域:
分析化学
·
生物化学
·
材料科学
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DOI
PubMed
高影响因子
Frontiers in Chemistry
·
2023
·
IF 5.5
Jia Liu,Su-Hang He,Hugues Lambert,Tung-Chun Lee
Resazurin (Alamar Blue, RZ) is a widely utilized fluorescent probe for biological sensing, whose fluorescent intensity can be modulated by changing its redox states; thereby, electrochemical reactivity of RZ is of significance when designing a sensing assay. Herein, we report novel two-way electrochemical reactivity modulation of RZ using host-guest complexation with rigid molecular containers cucurbit[ n ]uril (CB n , n = 7, 8). The complexation between CB n and RZ is confirmed by 1 H NMR measurements and supported by computational simulation, and the binding constants are determined via UV-vis titration. Notably, the voltametric data highlights that the redox reactivity of RZ can be activated or deactivated upon encapsulation by CB8 or CB7, respectively. This two-way reactivity modulation is hypothesized to be mediated by the difference in cavity volume that favors or hinders the approach of water molecules to the encapsulated reaction center during the reduction process. Despite the similar cavity size to CB, molecular containers such as cyclodextrins (CDs) exhibit considerably weaker modulation effects. Our approach can potentially be applied to other redox processes that involve proton transfer, and open new possibilities in supramolecular electrochemistry.
研究领域:
分析化学
·
超分子化学
·
生物传感
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产品关联
DOI
PubMed
高影响因子
FUEL
·
2024
·
IF 6.7
Wei-An Huang,Rui Su,Jing-Wen Wang,Yu Fan,Lin Jiang,Xuan Li,Jie Cao
The development of carbon (CO 2 ) dioxidecapture, utilization, and storage methods is crucial to achieving carbon neutrality. The use of supercritical CO 2 (sc-CO 2 ) in enhanced oil recovery applications offers a promising carbon utilization route; however, its application in petroleum exploration and production is limited by its low viscosity. Here, a host–guest complex was synthesized based on acetylated-β-cyclodextrin (ACD) and polyphthalamide (PPA) to enhance the viscosity of sc-CO 2 , and various techniques were used to characterize its structure. The results showed that adding 2.0 wt% ACD-PPA/10 wt% ethanol at an ACD/PPA molar ratio of 1:3 increased the viscosity of sc-CO 2 to 4.36 mPa·s, an increase of ∼ 109 times compared with pure sc-CO 2 . The mechanism for viscosity enhancement involves the building of a large number of C O bonds between the ACD and CO 2 molecules, contributing to the polymer’s high solubility in sc-CO 2 . Meanwhile, a strong hydrogen bond network is formed between the hydroxyl groups of the PPA terminal groups. Hence, a supramolecular system is developed through interactions of the host and guest molecules, which dramatically improves the viscosity of sc-CO 2 . Increasing the viscosity of sc-CO 2 allows it to be used in underbalanced drilling, anhydrous fracturing, thick oil extraction, etc., as well as being valuable in the field of carbon capture and storage.
研究领域:
材料科学
·
化学工程
·
石油工程
·
碳捕集与利用
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产品关联
DOI
高影响因子
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
·
2022
·
IF 3.571
He Cheng,Jie Song,Zhiyi Yao
Rocuronium is widely used in surgery as a neuromuscular relaxant, but it has been difficult to accurately control its specific dosage in clinical operation. Therefore, the development of fast and instant rocuronium detection methods has important application value for reducing risks and safeguarding health. In this study, N, N, N -trimethyl-4-(pyrene-1-butyl)-ammonium bromide (PyBTA) was designed as a probe to detect rocuronium rapidly. The method relied on replacing PyBTA in sugammadex with rocuronium to induce changes in fluorescence intensity of PyBTA, thereby realizing quantitative detection. Its sensing performance and detection mechanism were explored systematically by spectroscopy. The linear range of this method was 0.5–10 μM and the detection limit of it was 0.3 μM. In addition, we confirmed that the host-guest interaction among PyBTA, sugammadex, and rocuronium was mainly driven by electrostatic and hydrophobic interactions.
研究领域:
药理学
·
分析化学
·
生物医学工程
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DOI
高影响因子
Chemistry-An Asian Journal
·
2018
·Vol. 14
·期 1
·235-242
·
IF 3.692
Weitao Xu,Jinglan Kan,Bo Yang,Timothy J. Prior,Bing Bian,Xin Xiao,Zhu Tao,Carl Redshaw
Graphical Can I have some pumpkin soup, please? In the host–guest complexes formed between cucurbit[8]uril and the alkyl-substituted 4-pyrrolidinopyridinium salts 4-(C 4 H 8 N)C 5 H 5 NRBr (R=Et, n -butyl, n -pentyl, n -dodecyl), the orientation of the guest molecule changes with the length of R. Solid state structures are different to those observed in solution, and for R= n -pentyl, there are two different interactions between Q[8] and the guest. The interaction between cucuribit[8]uril (Q[8]) and a series of 4-pyrrolidinopyridinium salts bearing aliphatic substituents at the pyridinium nitrogen, namely 4-(C 4 H 8 N)C 5 H 5 NRBr, where R=Et (g1), n -butyl (g2), n -pentyl (g3), n -hexyl (g4), n -octyl (g5), n -dodecyl (g6), has been studied in aqueous solution by 1 H NMR spectroscopy, electronic absorption spectroscopy, isothermal titration calorimetry and mass spectrometry. Single crystal X-ray diffraction revealed the structure of the host–guest complexes for g1, g2, g3, and g5. In each case, the Q[8] contains two guest molecules in a centrosymmetric dimer. The orientation of the guest molecule changes as the alkyl chain increases in length. Interestingly, in the solid state, the inclusion complexes identified are different from those observed in solution, and furthermore, in the case of g3, Q[8] exhibits two different interactions with the guest. In solution, the length of the alkyl chain plays a significant role in determining the type of host–guest interaction present.
研究领域:
化学
·
超分子化学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2025
·
IF 11.5
Shan He,Pei-Juan Wu,Li Zhang,Jia-Xue Wu,Hou-Li Li,Kun Yi,Qiu-Yun Sun,Zi-Yang Wang,Yu-Xin Yue,Dong-Sheng Guo,Ke Hu,Xiao-Bei Huang,Wen-Juan Wan
Myopia is one of the most common visual impairments worldwide. Recent studies suggest that scleral hypoxia may act as an early trigger for myopia, initiating oxidative stress (OS) that disrupts extracellular matrix (ECM) remodeling and, in turn, drives axial elongation. In this study, we constructed a novel hypoxia-responsive host-guest complex, DOX@SAC4A, by encapsulating doxycycline (DOX) within sulfonated azocalix[4]arene (SAC4A). In vitro, this system significantly reduced DOX cytotoxicity and enabled efficient hypoxia-triggered drug release. Moreover, the intrinsic activity of SAC4A synergistically enhanced the antioxidant and anti-apoptotic effects of DOX, helping to maintain ECM homeostasis. In vivo studies further confirmed that DOX@SAC4A selectively targeted hypoxic sclera and markedly increased local drug accumulation. Consequently, it effectively suppressed myopia progression in guinea pigs by delaying axial elongation and alleviating myopic refractive shift. In conclusion, DOX@SAC4A is a multifunctional drug delivery system that offers both therapeutic effects and targeted delivery. These results present a promising candidate and an improved delivery strategy for myopia prevention and control.
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PubMed
高影响因子
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