阿拉丁SCI论文搜索工具

JOURNAL OF HETEROCYCLIC CHEMISTRY · 2014 ·Vol. 52 ·期 1 ·284-295 · IF 0.873

KOH-Oriented Ring Openings of N-Tosylaziridines with Carboxylic Acids in DMSO

F. Zhang,H. Chang,W. Wei

A facile and efficient KOH-oriented regioselective ring-opening reaction for the acetolysis of N -tosylaziridines in DMSO was developed under mild conditions. This operationally simple protocol could tolerate a variety of functionalized carboxylic acids as well as several N -tosylaziridines. Moreover, this strategy provided the corresponding ring-opening products with good results.

CAS / MDL: 865-49-6

研究领域: 有机化学 · 合成化学

✓ 已验证产品关联 DOI 高影响因子

查看原文查看 PubMed

SCIENCE OF THE TOTAL ENVIRONMENT · 2021 · IF 7.963

Degradation of antibiotic Cephalosporin C in different water matrices by ionizing radiation: Degradation kinetics, pathways, and toxicity

Xiaoying Chen,Jianlong Wang

Cephalosporin antibiotics are ubiquitous emerging pollutants in various aquatic environments due to their extensive production and application. Herein, the radiolytic degradation of antibiotic Cephalosporin C (CEP-C) in different water matrices was comprehensively investigated using gamma radiation at various experimental conditions. The results revealed that CEP-C oxidation obeyed pseudo first-order kinetics, and 100%, 94.9%, 67.0%, 44.6% and 34.5% removal of CEP-C with 10–200 mg/L was achieved at 0.4 kGy, respectively. The degradation was faster at higher absorbed dose and acidic conditions (pH = 3.5). The inorganic anions, including SO 4 2− , NO 3 − , and HCO 3 − , had negative influence on the degradation of CEP-C, the corresponding rate constant decreased from 4.603 to 3.667, 1.677 and 2.509 kGy −1 respectively in the presence of SO 4 2− , NO 3 − , and HCO 3 − . The analysis of intermediate products indicated that CEP-C was oxidized to generate about 10 intermediate products. Besides, it was inferred that the thioether sulfur oxidation , β-lactam ring opening, acetyl dissociation from dihydrothiazine ring and D-α-aminohexylamide group abscission were the major reaction mechanisms of CEP-C degradation by gamma radiation. Importantly, the antibacterial activity of CEP-C could be completely vanished by gamma radiation alone, while more toxic intermediate products might be formed. Addition of hydrogen peroxide and peroxymonosulfate could significantly improve the CEP-C degradation, and reduce the toxicity of intermediates of CEP-C degradation. Similar degradation behavior was observed in the groundwater and wastewater, implying that ionizing radiation can be used for degradation of Cephalosporin in water and wastewater.

CAS / MDL: 70693-62-8

研究领域: 环境科学 · 辐射化学 · 水处理 · 毒理学

✓ 已验证产品关联 DOI PubMed 高影响因子

查看原文查看 PubMed

查找使用阿拉丁产品的科研文献

与阿拉丁产品相关的已发表科研成果

热门产品

KOH-Oriented Ring Openings of N-Tosylaziridines with Carboxylic Acids in DMSO

Degradation of antibiotic Cephalosporin C in different water matrices by ionizing radiation: Degradation kinetics, pathways, and toxicity