Food Biophysics
·
2020
·Vol. 15
·期 4
·452-462
·
IF 2.387
Zeng Chaoxi,Wan Zheng,Xia Huiping,Zhao Haiyang,Guo Shiyin
In this study, naturally occurring ingredient diosgenin was utilized as an organogelator for structuring canola oil. Results show that stable diosgenin-based organogel can be obtained at only 2% of diosgenin concentration when the gel preparation temperature is 100 °C. Oil binding capacity and rheological properties of the organogel were investigated. Results demonstrate that these two macroscopic characteristics of the organogels can be significantly modified by simply changing the gel preparation temperature or diosgenin concentration. When the preparation temperature was 120 °C and the diosgenin concentration higher than 4%, oil binding capacity of at least 90% were obtained. Furthermore, higher gel preparation temperature resulted in higher G′values of the diosgenin-based organogels. According to the results analyzed by polarized light microscopy, XRD and FT-IR, it can be found that the possible gelation mechanism of the diosgenin-based organogels is formation of supramolecular structures by self-assembly of diosgenin molecule crystals via hydrogen bonding interaction. Varying gel preparation conditions of the organogels lead to self-assembly of diosgenin molecules to form different microstructures. Therefore, diosgenin can be considered as a good organogelator for producing functional organogel from canola oil. The novel diosgenin-based organogel is expected to be widely used in bio-related fields such as food and pharmaceutical industries.
研究领域:
食品科学
·
材料科学
✓ 已验证
DOI
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 67
·62478-62484
·
IF 3.289
Wen'en Li,Haibo Wang,Zeliang Wei,Juewei Ning,Limei Ma,Huajie Zheng,Hai Niu,Wen Huang
To improve the effect of thrombosis therapy, an amphiphilic supramolecular prodrug consisting of diosgenin derivative (theophylline–diosgenin) and uracil-terminated poly(ethylene glycol) (PEG-U) was designed and synthesized successfully. The prodrug could self-assemble into micelles which was not only enhanced the drug solubility but also prolonged systemic circulation. Bleeding time assay confirmed that the micelles have a better antithrombotic activity compared to diosgenin in vivo, and platelet aggregation assay in vitro got the same results. The low cytotoxicity of supramolecular copolymer micelles was confirmed by MTT assay against LO2/HK-2 cells and acute toxicity studies in mice. Based on these results, the supramolecular prodrug micelles are very promising candidates for thrombosis therapy.
研究领域:
药学
·
生物医学工程
✓ 已验证
DOI
高影响因子
PROCESS BIOCHEMISTRY
·
2015
·
IF 2.516
Chang-Wei Zhang,Cheng-Zhang Wang,Ran Tao,Chuanjie Fang
Polyprenols are one of the most important lipid components in Ginkgo biloba leaves (GBLs). In this study, an enzymolysis-based ultrasound extraction procedure of GBL polyprenol (GBP) lipids was established, and the antioxidant activities of polyprenols and six kinds of polar fractions separated from GBL lipids via an optimal extraction procedure were studied. The results showed that the optimum conditions were an enzyme quantity of 0.5 g (the mass ratio of cellulase and pectinase was 1:2, and the enzyme activity was 60 U/mg), enzymolysis pH of 4.5, and temperature of ultrasound of 45 °C. Under these conditions, the yield of polyprenols was 0.80% ± 0.22%, which is 69.70% higher than that obtained by direct petroleum ether extraction. In addition, concentration c (content of polyprenols was 91.53%), fraction 3 (content of polyprenols was 43.28%), polyprenols (content of polyprenols >99%), and fraction 3 showed the strongest scavenging effect on DPPH (2,2-diphenyl-1-picrylhydrazyl), ABTS (2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid)), superoxide anion, and hydroxyl radicals with the corresponding IC 50 values of 236.9, 76.84, 80.23, and 113.9 μg/mL. It is inferred that GBL lipids with different concentrations of polyprenols could play different roles in the research and development of cosmetics and functional food.
研究领域:
植物化学
·
药理学
✓ 已验证
产品关联
DOI
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
·
2020
·
IF 4.244
Chang-Wei Zhang,Ming-Fei Li,Ran Tao,Mi-Jun Peng,Zhi-Hong Wang,Zhi-Wen Qi,Xing-Ying Xue,Cheng-Zhang Wang
Polyprenol is an important active ingredient in Ginkgo biloba leaves (GBL) with great industrial application potential. In this paper, a novel high energy ball milling extraction technology coupled with silver-thiolate material purification method was developed, with which a high purity of GBL polyprenol (GBP) was obtained. Results showed that this method had a high extraction efficiency, and GBP of a purity up to 99.8 % was produced. GBP liposomal gel (GLG) was prepared, and its stability, rheological property, release behavior and antibacterial activity were evaluated. According to the results, GLG had a small particle size and high homogeneity which was desirable for topical application, and it also manifested good physiochemical stability and suitable plastic flow property. In addition, GLG illustrated excellent inhibitory effect against Staphylococcus aureus , Escherichia coli , Candida albicans and Streptococcus pneumoniae , and the minimal inhibitory concentration was 25∼200 μg/mL. The systematic research provided a useful method for the biorefining of GBL.
研究领域:
植物化学
·
药剂学
·
微生物学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）