NEW JOURNAL OF CHEMISTRY
·
2023
·Vol. 47
·期 23
·11318-11324
·
IF 3.3
Jiazheng Zhu,Chengjie Duan,Sen Ye,Qizhong Zhang,Kun Li,Guangke He,Xiang Liu,Zhiguo Zhang
Exploring synthetic methods and catalysts that are easy to handle, highly active, and low-cost for producing industrially important chemicals is a long-term goal in both science and industry. Herein, we present a general and facile Ni-catalyzed reductive amination of aldehydes/ketones methodology using hydrazine as both nitrogen and hydrogen sources, instead of the traditionally used hydrogen gas and ammonia. The mesostructured alumina-supported Ni catalyst with a relatively high ratio of Ni0 and small-sized Ni nanoparticles plays a critical role in this transformation, resulting in 55 aldehydes/ketones successfully converting to their corresponding primary amines with 61–99% yields. This work outlines a low-cost yet robust catalytic methodology for the facile and general synthesis of primary amines for practical laboratory and industrial application.
研究领域:
有机化学
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催化化学
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产品关联
DOI
高影响因子
JOURNAL OF ORGANIC CHEMISTRY
·
2021
·
IF 4.354
Hao Song,Yao Xiao,Zhuohua Zhang,Wanjin Xiong,Ren Wang,Liangcheng Guo,Taigang Zhou
A simple and efficient copper-catalyzed selective transfer hydrogenation of nitriles to primary amine-boranes and secondary amines with an oxazaborolidine–BH3 complex is reported. The selectivity control was achieved under mild conditions by switching the solvent and the copper catalysts. More than 30 primary amine-boranes and 40 secondary amines were synthesized via this strategy in high selectivity and yields of up to 95%. The strategy was applied to the synthesis of 15N labeled in 89% yield.
研究领域:
有机化学
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催化化学
✓ 已验证
DOI
PubMed
高影响因子
DYES AND PIGMENTS
·
2019
·
IF 4.018
Weiguo Chen,Pu Gao,Hua Jiang,Zhihua Cui
Chemical modification of silk fibroin is a useful method for improving its performance. There are many existing methods of protein modification, some of which are limited for application to silk by the disadvantages of severe reaction conditions, poor reaction selectivity and problems with characterization of the product. In this paper, a series of dyes containing aromatic primary amine groups was designed and synthesized for modification of silk fibroin via the Mannich reaction. This three-component Mannich modification showed several advantages, such as mild reaction conditions, good selectivity, easy characterization and high fastness. In particular, the degree of modification could be established visually according to the color yield and the color fixation on silk fibroin. Therefore, the Mannich reaction of silk with dyes containing aromatic primary amine groups may become a novel reactive dyeing method. Studies of structure-performance relationships showed that suitable dyes for dyeing of silk should meet the following criteria: (1) High nucleophilicity of the aromatic primary amine group. (2) No high electron cloud density center around the amino group.
研究领域:
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
BIOMEDICAL CHROMATOGRAPHY
·
2020
·Vol. 34
·期 6
·e4824
·
IF 1.728
Chu Chu,Linmin Lian,Caijing Liu,Jing Li,Hui Mao,Luyi Jiang,Jizhong Yan
Electrokinetic supercharging, a convenient and powerful online preconcentration technique in capillary electrophoresis, was introduced and evaluated for the determination of two alkaloids, berberine and jatrorrhizine, in mice fecal samples for the first time. The method depended on using a bare fused silica capillary (50 cm × 50 μm i.d.) and applying the voltage of 25 kV with UV detection at 205 nm. Parameters that affect the separation and preconcentration efficiency have been optimized. The optimum conditions used were as follows: background electrolyte consisting of 40mM sodium dihydrogenphosphate containing 30% methanol (v/v); hydrodynamic injection of 20mM KCl (50 mbar × 150 s) as the leading electrolyte; electrokinetic injection of the sample (+15 kV, 120 s) followed by the hydrodynamic injection of 30mM dodecyl trimethyl ammonium chloride (50 mbar × 12 s) as the terminating electrolyte. The results showed that the detection sensitivity of berberine and jatrorrhizine was, respectively, improved up 2740- and 2928-fold compared with normal injection, providing limits of detection lower than 3 ng/mL with good repeatability in areas (relative standard deviation < 3%). In summary, the developed method proved its ability in analyzing trace alkaloids in complicated biological samples.
研究领域:
分析化学
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药理学
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2023
·
IF 4.7
Qiqi Lu,Xiu-Zhi Wei,Haiyong Wang,Qi zhang,Xinghua Zhang,Lungang Chen,Jianguo Liu,Longlong Ma
The selective hydrogenation of nitrile represents an atom-economical and reliable method to synthesize primary amine, a privileged compound in chemistry, biology, and medicine. However, this approach often displays severe selectivity issues, and additives or reducing agents are generally required to solve this problem. In this work, we aim to synthesize primary amine on a green catalytic system and probe into the catalytic mechanism of Pd-Ni interaction using benzonitrile (BN) as a model compound. The nitrile hydrogenation reaction was catalyzed by bimetallic Pd-Ni oxide nanospecies confined in Silicalite‑1 (S-1) zeolite using H 2 as hydrogen donor without any additive which was environmentally friendly and economic. A 92% yield of benzylamine (BA) was achieved on the [email protected] catalyst with a turnover number (TON) of 1667, and such BA yield was still maintained in upscaling experiment. Detailed characterizations shed light on the mechanism of the extraordinary performance of Pd-Ni oxide nanospecies on base-free nitrile hydrogenation.
研究领域:
化学
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材料科学
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产品关联
DOI
高影响因子
JOURNAL OF POLYMER RESEARCH
·
2025
·Vol. 32
·期 10
·1-10
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IF 2.8
Du Chenglong,Huang Zhibo,Wu Xiaohui,Jing Shuailin,Wang Feifei,Liu Xiao,Shi Yan,Zhang Liqun
The increasing demand for brominated butyl rubber (BIIR) has intensified the use of conventional ZnO/sulfur-based curing systems, raising significant environmental concerns. Herein, we present a sustainable, ZnO- and sulfur-free cross-linking strategy enabled by a primary amine, octadecylamine (ODA), which serves as an efficient cross-linker for BIIR. Upon thermal activation at 160 °C, ODA reacts with the benzylic bromide groups of BIIR via dual nucleophilic substitution, forming stable covalent networks. The cross-link density and resultant mechanical properties exhibit a positive correlation with ODA loading, reaching an optimum at 3 phr. In contrast, octadecyltrimethylammonium bromide (OTAB) and diethylamine hydrochloride—lacking N–H protons—show negligible reactivity, highlighting the essential role of the primary amine functionality in the cross-linking mechanism. This work establishes a quantitative structure–efficiency relationship for amine-based cross-linkers, providing both experimental validation and mechanistic insight for the rational design of environmentally benign vulcanization processes in halogenated elastomers.
研究领域:
高分子化学
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材料科学
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环境友好材料
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橡胶工业
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可持续化学
✓ 已验证
产品关联
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2023
·
IF 4.2
Haowen Shi,Zuoying Cao,Jia Li,Lihan Zhang,Mingyu Wang,Qiyuan Zheng,Jiawei Du,Wenjuan Guan,Guiqing Zhang
Deep separation of tungsten from molybdenum has become a bottleneck in molybdenum metallurgy, especially in high-chloride aqueous systems, because of competitive extraction. A new primary amine extractant, 3-(nonyloxy)propane-1-amine (NNA), was designed and synthesized to separate tungsten and molybdenum. Over 96% extraction efficiency of tungsten was achieved by NNA with the optimal conditions, with the saturated capacity exceeding 55 g/L. Meanwhile, a high separation coefficient of 40 for W to Mo was obtained by single-stage extraction. The extraction mechanism of different NNA concentration ranges was determined based on the H+–MoO42––WO42– aqueous system. The extraction order was Mo3W4O246–, Mo2W5O246–, and [WO42–, MoO42–], with the stoichiometric numbers of NNA determined as 8, 8, and 1, respectively. Remarkably, NNA exhibited good performance in high-chloride aqueous systems. The separation coefficient toward W over Mo was greater than 3.00 × 104 with a three-stage countercurrent extraction. In conclusion, NNA has a tremendous potential application value for tungsten and molybdenum separation, especially in complex systems.
研究领域:
冶金学
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化学工程
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材料科学
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产品关联
DOI
高影响因子
Microbiology Spectrum
·
2025
·
IF 3.8
Heng Zhang,Yizheng Zhou,Hanmo Yang,Xinyi Tao,Yinping Chen,Fuqiang Dong,Yi Sun
The growing resistance of Aspergillus to azoles poses a significant challenge in treating invasive fungal infections. This study aimed to investigate the synergistic effect of berbamine hydrochloride (BBM) combined with azoles in treating Aspergillus fumigatus and explore the role of efflux pump inhibition in this synergy. The efficacy of combining BBM with itraconazole (ITC), voriconazole (VOR), and posaconazole (POS) was tested against 69 A. fumigatus strains that had been identified using the M38-A3 broth microdilution method. quantitative reverse transcription PCR (RT-qPCR) was used to measure gene expression related to synergy, while flow cytometry was employed to assess mitochondrial reactive oxygen species (ROS) levels, and Rhodamine 6G exocytosis assays were performed to quantify efflux pump activity. BBM alone showed no significant antifungal activity. BBM combined with POS exhibited synergy against 66 strains (95.7%), while two clinical isolates (Af05/Af08) and one defective strain (Δcdr1B) showed no synergy. Synergy with ITC was observed in three strains (4.3%), but not with VOR. In the non-synergistic Af05 and Af08 strains, the expression of the cdr1B gene was significantly lower compared to wild-type (WT) strains. ROS levels increased significantly in WT with POS and BBM combination therapy, but not in the defective strains. Glucose uptake was also reduced in the POS-BBM combination. BBM enhances azole sensitivity in A. fumigatus primarily by inhibiting the cdr1B-mediated efflux pump, supported by reduced Rhodamine 6G exocytosis and synergy loss in cdr1B-deficient strains. ROS accumulation and metabolic disruption may further contribute to this synergy. Targeting efflux pumps with BBM provides a novel strategy to combat azole resistance.
研究领域:
医学
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微生物学
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药理学
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Yiqing Chen,Yingbin Lv,Wei Su,Guangyu Wu,Peiyuan Li
Wound infections are a significant threat to human health. Therefore, the development of wound dressings with rapid antimicrobial properties is crucial to promote effective wound healing. In this study, chitosan (CS) was combined with gelatin (GE) to create an active film dressing (GC/BP) loaded with berberine hydrochloride (BH) and polypyrrole (PPY). After the incorporation of the bioactive materials, the film retained good mechanical properties, allowing it to withstand changes in the external environment of the wound. The antimicrobial effect of the GC/BP film exceeded 99 % after brief exposure to near-infrared light. In addition, the GC/BP film demonstrated a strong antioxidant effect with a DPPH clearance rate of 92.54 % within 48 h. In vivo experiments revealed that GC/BP films could enhance angiogenesis by upregulating the expression of the growth factor CD31, reducing oxidative stress by downregulating TNF-α expression, and accelerating the formation of fibrous tissues to promote wound healing. Importantly, the GC/BP film exhibited no cytotoxicity or hemolysis and demonstrated good biocompatibility. In conclusion, the GC/BP film is a safe and effective wound dressing with a promising potential for promoting wound healing.
研究领域:
生物材料学
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医学工程
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药剂学
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产品关联
DOI
PubMed
高影响因子
APPLIED CATALYSIS A-GENERAL
·
2023
·
IF 5.5
Huanyu Zhao,Yurong He,Xiaochen Wang,Jie He,Anqiu Liu,Zehui Zhang
Selective hydrogenation of nitriles is a feasible route to synthesize primary amines. While highly desirable, conducting the synthesis under mild conditions is challenging. We report non-precious zinc and aluminum oxides supported Ni catalysts (Ni/ZnAlO x ) facilely prepared by calcination and reduction of NiZnAl layered double hydroxide (LDH) precursors. The optimized Ni/ZnAlO x -600 catalyst demonstrates great activity towards the selective hydrogenation of nitriles to primary amines. Proper-size metallic nickel provides the hydrogenation centers, and the presence of Ni-Zn alloys indicates strong metal-support interactions, which can produce electron-deficient nickel species and enhances the chemisorption of the C N bonds on the catalyst surface. The introduction of Zinc provides strong Lewis acid sites which also contribute to the catalytic activity. Based on the catalyst characterizations and control experiments, a plausible mechanism is proposed. This catalyst shows good stability and is conducive to the transformation of a variety of aromatic and aliphatic substrates, demonstrating potential application prospects.
研究领域:
化学
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催化科学
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2024
·
IF 5.3
Qian Ding,Jinlu Shang,Liuxuan Yang,Li Deng,Siqiong Wu,Jing Chen,Jing Yang,Ke Wang,Chunhong Li,Junyan Chen,Meiling Zhou
The development of innovative therapeutic strategies that combine multiple treatment modalities is essential for effective cancer therapy. In this study, we engineered berberine (BER)-loaded mesoporous polydopamine (MPDA) nanoparticles (BER-MPDA) to enhance anti-tumor efficacy through synergistic chemotherapy and photothermal therapy (PTT). The mesoporous structure of MPDA allowed for a high loading capacity of BER, a natural isoquinoline alkaloid with known anticancer properties. Upon near-infrared laser irradiation, BER-MPDA exhibited marked photothermal conversion efficiency, leading to effective tumor cell ablation. Both in vitro and in vivo experiments indicated that the combined treatment of BER-MPDA with near-infrared laser irradiation resulted in superior tumor inhibition compared to monotherapy. The synergistic effect was attributed to the enhanced cellular uptake and the simultaneous induction of chemo- and photothermal cytotoxicity. Our findings suggest that BER-MPDA represents a promising platform for multimodal cancer therapy, offering a potent approach to overcoming the limitations of conventional chemotherapy and PTT.
研究领域:
药学
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肿瘤学
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纳米医学
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产品关联
DOI
PubMed
高影响因子
CHIRALITY
·
2025
·Vol. 37
·期 1
·e70012
·
IF 3
Binhao Wang,Yu Shen,Ruonan Hao,Shuheng Pan,Ruizhi Han,Ye Ni
Efficient enantioselective separation is a critical process in pharmaceutical and chemical industries for the production of chiral compounds. Herein, we developed a novel approach for the efficient enantioselective separation of primary amines using supercritical fluid chromatography (SFC) with a commercially available SFC column, Cel1 . The key factors of separation, including cosolvent ratios, total cosolvent percentages, and temperature, were systematically assessed in this study. It revealed that utilization of a cosolvent mixture consisting of methanol and isopropanol in a 1:3 (v/v) ratio with a low total cosolvent percentage of 5% resulted in superior retention and selectivity. Additionally, it was observed that maintaining mid-range temperatures at 30 and 35°C achieved optimal balance between retention and efficiency. Employment of commercially available SFC columns streamlined the separation process, reducing analysis time and labor. This study highlights the effectiveness of SFC as a powerful tool for conducting high-throughput enantioselective separations in pharmaceutical and fine chemical industries.
研究领域:
药物化学
·
分析化学
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产品关联
DOI
PubMed
高影响因子
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