ADVANCED MATERIALS
·
2025
·
IF 26.8
Quanwei Sun,Huiyu Lu,Wenshuo Yang,Zhengwei Song,Chen Chen,Xu Ruan,Min Luo,Yunlong Li,Huihui Li,Zexin Yang,Kang Liu,Wencui Shang,Yujing Xu,Qinghua Wu,Wei Shen,Ye Yang,Dengke Yin
Humoral immunity-cancer crosstalk has gained attention recently owing to its impact on tumor immune responses and therapy responsiveness. Here, it is shown that epithelial breast cancer cells can directly bind with non-antigen-specific IgA, dependent on polymeric immunoglobulin receptor (PIGR)-mediated transcytosis function, modulating tumoral inflammatory genes and sensitizing antitumor response. To harness this biology, a hybrid tumor vaccine is designed by covering the adjuvant-loaded cancer cell vesicles with a calcium phosphate shell, which retains the antigen information of the original tumor cells and exhibits robust mucosal adhesion in nasal tissues. Following intranasal vaccination, such a hybrid vaccine preferentially activates germinal center responses in nasal-associated lymphoid tissues and drives the production of tumoral antigen-specific IgA-dominated humoral immunity in both serum and lung through the property of “common mucosal immune system”, thus coordinating cellular immune responses to prevent lung colonization of IgA-opsonized breast cancer. In the inoperable and postoperative breast cancer model, intranasal vaccination with the hybrid vaccine also enables the amplification of the therapeutic benefits of local/systemic therapies. In summary, this work presents insights into the antitumor biology of IgA in epithelial breast cancer and explores a highly effective vaccine strategy focused on governing IgA-dominated humoral immunity to combat breast cancer, especially lung metastasis.
研究领域:
肿瘤学
·
免疫学
·
微生物学
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry A
·
2022
·Vol. 10
·期 38
·20414-20423
·
IF 14.511
Huanhuan Sun,Wei Hua,Shiyu Liang,Yueying Li,Jian-Gan Wang
Constructing a semiconductor–liquid junction (SCLJ) with efficient charge transfer and excellent anti-photocorrosion is crucial yet challenging for photoelectrochemical (PEC) water oxidation. Herein, we propose an effective surface reconstruction strategy to create a self-adaptive SCLJ for significantly enhancing the PEC activity and stability of BiVO4 photoanodes. It is revealed that a low-valence metal oxide (e.g., NiFeOx) serrated cocatalyst could be in situ transformed into a uniform and seamless oxygen-vacancy-rich metal (oxy)hydroxide nanolayer during the initial PEC test cycles. Such an intriguing reconstruction creates a self-adaptive SCLJ to promote hole trapping/migration at the semiconductor/cocatalyst junction and improve the water oxidation kinetics as well as photocorrosion resistance at the electrode/electrolyte interface. Remarkably, the self-adaptive SCLJ enables BiVO4 to show an impressive photocurrent density of 5.1 mA cm−2 at 1.23 V vs. RHE and superior working durability over 30 h. This study provides a fundamental insight on designing a self-adaptive SCLJ for highly efficient PEC water electrolysis.
研究领域:
材料科学
·
电化学
·
可再生能源
✓ 已验证
产品关联
DOI
高影响因子
ACS Nano
·
2023
·
IF 17.1
Yangkun Huang,Jinpeng Huang,Wenxiang Yin,Fei Xie,Benjamin Coleman,Yaoyu Cao,Satoshi Aya,Wei Zhu,Zhijie Yang,Lingxiang Jiang
It is an ongoing endeavor in chemistry and materials science to regulate coacervate droplets on a physiologically relevant spatiotemporal scale to ultimately match or even surpass living cells’ precision, complexity, and functionality. Herein, we develop a magnetic strategy orthogonal to the thermal, pH, light, or chemical counterparts that are commonly employed by biotic or artificial systems; its successful implementation thus adds a missing piece to the current arsenal of manipulative methodologies. Specifically, we paramagnetize the otherwise diamagnetic coacervate droplets by cooperatively combining paramagnetic ingredients (including organic radicals, metal ions, and Fe3O4 nanoparticles) and coacervate ingredients to obtain “MagCoa” droplets. A simple model is derived theoretically to account for migration and division of MagCoa droplets in an uneven magnetic field. Experimentally, we produce an array of compartmentalized and monodispersed droplets using microfluidics and magnetically steer them with uniformity and synchronicity. We design and fabricate spatial magnetic modulators to engineer the landscape of a magnetic field that, in turn, directs the MagCoa droplets into predesigned patterns in a reconfigurable fashion. These programmable liquid patterns can be potentially extended to dynamic assembly and information encryption. We envision that the toolbox established here is of generality and multitudes to serve as a practical guide to control droplets magnetically.
研究领域:
化学
·
材料科学
·
软物质物理
·
生物物理学
·
胶体科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2020
·
IF 6.785
Yu Ma,Yingqiu Zhang,Xiangyuan Li,Peng Yang,Jie-Yu Yue,Yu Jiang,Bo Tang
Phosphate is an important anion in both the aquatic environment and biological systems. The search for a selective and sensitive phosphate ratiometric fluorescent probe to quantify the phosphate level in water samples and body fluids is of great significance for the protection of the ecological environment and human health. Here, a porphyrin-based nano metal–organic framework (NMOF), PCN-224, was successfully exploited as a simple but highly sensitive and selective single-component ratiometric fluorescent probe with accurate composition and measurable structure for the quantitative determination of phosphate, based on the interesting double-emission fluorescence of the porphyrin ligand itself. Compared with other zirconium-based NMOF probes for phosphate, the reduced number of connections for ZrO clusters with the ligand in PCN-224 obtained by a linker-elimination strategy simultaneously provides more active recognition sites for phosphate, which effectively improves the sensitivity of the zirconium-based NMOF probes. The detection limit of the probe is only 54 nM. Additionally, the accuracy of the ratiometric detection based on this probe was further proved by the detection of phosphate in human serum and drinking water.
研究领域:
环境科学
·
分析化学
·
生物化学
✓ 已验证
DOI
高影响因子
AICHE JOURNAL
·
2025
·
IF 4
Daofan Ma,Yanjun Deng,Guangwei Wang,Youguang Ma,Chunying Zhu,Xiangyang Tang
Nanofluid droplets have considerable applications in industry. In this study, the coalescence dynamics of nanofluid droplets in an expansion chamber structure microchannel were visually investigated; the shape and liquid bridge evolutions of droplets were studied systematically. Five droplet coalescence flow patterns were observed: non-contact, double coalescence, cascade coalescence, compact slug flow, and jetting flow regimes. Due to the adsorption of nanoparticles on the fluid interface, a solidified layer is formed, which restrains the curvature change of the liquid bridge, slowing down the shrinkage of the liquid bridge. The evolution of the liquid bridge neck width with time could be divided into two stages: the dispersed phase control stage and the continuous phase control stage. The nanoparticles could affect markedly the dispersed phase control stage, while having less effect on the continuous control stage.
研究领域:
流体力学
·
纳米技术
·
工业应用
✓ 已验证
产品关联
DOI
高影响因子
CORROSION SCIENCE
·
2024
·
IF 7.4
Fei Gao,En Su,Jiaming Hou,Jiale Wang,Yukun Zhou,Haotian Qin,Zhenhai Xie,Jinlong Mao,Huaiyu Li,Wenjie Tao,Yingqi Chen,Junyu Qian,Guojiang Wan
Long-term corrosion profile of molybdenum was studied in three different simulated body fluids up to 28 days, compared with magnesium, zinc, and iron from the perspective of biodegradable metals (bio-metals). Their corrosion rate, mode, products and surface characteristics were comprehensively fathomed. Strikingly, Mo showed progressively advantageous long-term corrosion behavior with the smallest corrosion rate, and most importantly, more uniform mode, as compared with the other three bio-metals. It also performed bilaterally under the simulated inflammatory and bovine serum protein added conditions, with different corrosion progressions. These findings provide an optimistic outlook in opting molybdenum as a new type of bio-metal.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
BIOMASS & BIOENERGY
·
2024
·
IF 5.8
Linhua Song,Yushan Jiang,Zhengzheng Zhang,Yuqing Ouyang
Hydrogen-supplied liquefaction technology is considered to be one of the most essential thermal treatment strategies for improving the quality of bio-oil. This study employed wood chips as feedstock, inert alkanes as dispersing solvent, and tetraline as hydrogen donor. The yields of bio-oil rose substantially from 45.2% to 69.2% and 68.3% with CaO and 8% NiO/γ-Al 2 O 3 catalysts, respectively, at 310 °C for 30 min with a ratio of wood chips to n -heptane of 1:8 g ml −1 . The reaction mechanism was examined using microcrystalline cellulose and lignin as model compounds. Tetralin offered the active hydrogen, while the strong alkalinity of CaO brought about high-temperature fragmentation of cellulose to produce small-molecule ethers, aldehydes, and ketones. These species would eventually transform into alcohols through engaging with the active hydrogen. The introduction of NiO/γ-Al 2 O 3 promoted the ring-forming reaction of cellulose-derived fragments, resulting in an increase of furan content (up to 29.97%). This phenomenon suggested that the varied catalysts exerted a remarkable impact on the hydrogen-supplied liquefaction of cellulose. The catalytic effect on lignin was evident in the breakage of the C–O bond in the side chain of phenol, leading to the generation of an impressive amount of phenolics. In light of changes in the generated products and calculation of the theoretical bond energies, the bond-breaking approaches and potential reaction pathways of biomass impacted by different catalysts were proposed, providing a theoretical foundation for the development and application of biomass energy.
研究领域:
能源植物学
·
催化化学
✓ 已验证
产品关联
DOI
高影响因子
COMPOSITES PART B-ENGINEERING
·
2019
·
IF 6.864
Syed Asadullah,Han Wu,Shiqi Mei,Deqiang Wang,Yongkang Pan,Dongliang Wang,Jun Zhao,Jie Wei
Polyimide (PI) may become a promising biomaterial for dental and orthopedic application due to its high mechanical strength , good biocompatibility and bio-stability as well as modulus of elasticity similar to the bone of human body. In this study, bioactive tantalum pentoxide (Ta 2 O 5 , TO)/polyimide (PI) composites (TPC) were fabricated by blending modification through a process of cold-pressing and sintering. The results revealed that the compressive strength , thermal stability, surface roughness , hydrophilicity and surface energy of TPC were significantly enhanced with the increase of TO content. Moreover, apatite mineralization of TPC in simulated body fluid (SBF) was obviously improved, in which TPC with TO of 50 wt% content (TPC50) displayed the best bioactivity . Furthermore, the cellular responses (adhesion, proliferation and differentiation) of rat bone mesenchymal stem cells (rBMSCs) to TPC were obviously upregulated with the increase of TO content. The results demonstrated that the TO content in the composites remarkably affected not only physical-chemical properties but also the cells behaviors. It can be suggested that TPC50 with improved surface properties and bioactivity as well as good cytocompatibility would have great potential and prospect for dental and orthopedic applications.
研究领域:
生物材料学
·
骨科与牙科应用
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2022
·
IF 14.224
Quanquan Guan,Jin Jiang,Yan Huang,Qing Wang,Zhaofeng Liu,Xuan Ma,Xiaona Yang,Yong Li,Shangqian Wang,Weiding Cui,Junwei Tang,Hua Wan,Qing Xu,Yiming Tu,Di Wu,Yankai Xia
Exogenous microparticles including microplastics are novel pollutants that could persist in the environment with potential health effects, while crucial data on their exposure in humans are still lacking. To understand the panorama of microparticles including microplastics exposure and distribution characteristics in different kinds of body fluids. A non-targeted microparticle internal exposure landscape analysis was done in thirteen kinds of human enclosed body fluids covering eight body systems. Totally 104 patients aged 24–96 years with an average age of 56 years were included in this study. After sample digestion, non-soluble microparticles were detected and identified with one Raman Microspectroscope under a strict quality control-particle detection system. Totally 702 microparticles with size ranging from 2.15 to 103.27 µm were detected in samples. Microparticles were identified into 84 substances or 66 molecules, most of which were firstly reported inside human body. Nine kinds of microplastics were originally reported in human body fluids with their size ranging from 19.66 to 103.27 µm. Microparticles exposure was unexpectedly high inside the human body despite the protection of biological barriers and membranes, raising awareness of the impact of particle pollution on sustainable development.
研究领域:
环境科学
·
医学
·
生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CRYSTENGCOMM
·
2020
·Vol. 23
·期 3
·678-683
·
IF 3.117
Shuqin Jiang,Yuanyuan Cao,Chenxi Zong,Yuanfeng Pang,Zhiwen Sun
Amorphous calcium phosphate (ACP), as a precursor phase of hydroxyapatite (HAP, the main inorganic mineral of bone) crystallization in a biological system is well documented. Numerous studies have shown that Mg2+ can chemically inhibit the transformation of ACP to HAP. Importantly, the inhibition effect is closely related to the addition time of Mg2+ for bone mineralization in vivo. However, Mg2+ is also widely used to promote bone growth and regeneration in the biomedical field. So, the regulatory role of Mg2+ in HAP crystallization remains elusive. In this study, the detailed effect of Mg2+ (especially the adding time) on ACP-mediated HAP crystallization is revealed in simulated body fluids. We reported that adding Mg2+ before ACP formation or in ACP stable stage can effectively inhibit HAP crystallization; however, in the near phase transformation stage (ACP is unstable), Mg2+ does not affect HAP crystallization. In particular, surface associated Mg2+ on ACP (compared to Mg2+ incorporation) is more suppressive to HAP crystallization. This results indicates that appropriate regulation of Mg2+ adding time is vital for amorphous mediated biomineralization, which sheds new light on HAP crystallization regulation.
研究领域:
生物材料学
·
骨生物学
✓ 已验证
DOI
高影响因子
INTERNATIONAL IMMUNOPHARMACOLOGY
·
2024
·
IF 4.8
Lisha Ye,Tianjiao Wang,Simin Wu,Hui Liu,Feng Liu,Chunqun Wang,Min Hu
The intestinal native protein H11 is one of the most immunodominant antigen of Haemonchus contortus . However, H11 combined with QuilA adjuvant shows only short-lived protection for animals. Nano-adjuvants have the huge potential to extend the immune response in human and animals. Here, we compared the immune responses induced by H11 combined with three nano-adjuvants including lipid nanoparticles (LNP), immunostimulating complex matrix (IMX) and AddaS03™. We measured the cytokine levels of goat PBMCs stimulated by H11 mixed with three nano-adjuvants and QuilA. Results showed that the transcriptions of IL-6, IL-8 and IFN-γ genes were significantly inhibited in all adjuvant group compared with PBS control. H11-IMX combination significantly up-regulated IL-2, IL-17 and TNF-α gene transcriptions. The H11-LNP group showed a significant increase in IL-17 and TNF-α transcriptions, while the H11-AddaS03™ group significantly increased IL-2 transcription. Additionally, mice immunized with these formulations were assessed for splenic lymphocyte proliferation. All H11-adjuvant combinations, except H11-LNP, significantly stimulated lymphocyte proliferation compared to the H11 alone and PBS control groups, with the H11-AddaS03™ combination showing the strongest effect. Analysis of serum antibody levels revealed that all immune groups induced high IgM levels, with H11-IMX inducing the highest IgG levels. Our results demonstrated that IMX or LNP combined with H11 mainly induced a Th17 cell immune response in goat PBMCs, while IMX or AddaS03™ combined with H11 could induce a strong humoral immune response in mice. This study elucidates the immune response profiles of different nano-adjuvant combined with H11 antigen, providing important insights for vaccine development against parasitic nematodes.
研究领域:
寄生虫学
·
免疫学
·
疫苗开发
✓ 已验证
产品关联
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2020
·Vol. 45
·期 6
·3343-3348
·
IF 3.288
Ming Li,Yu Peng,Fei Yan,Chunguang Li,Yiqiang He,Yue Lou,Dingxuan Ma,Yi Li,Zhan Shi,Shouhua Feng
A novel cage-based crystalline covalent organic framework, i.e. Cage-COF-TT (TT = triammonia–terephthalaldehyde), was prepared from a prism-like triammonia-containing molecular cage and terephthalaldehyde. Its ordered structure and porosity are expected to ensure efficient drug delivery as a potent carrier. The excellent cell viability of Cage-COF-TT was testified through MTT assays with respect to both normal mouse cells and normal human hepatocyte cells. In terms of drug delivery performance, Cage-COF-TT exhibit a high loading capacity and efficient drug release profile in a simulated body fluid environment. This work offers new insights into the design and development of a COF-based drug carrier and inspires the development of versatile tools for biomedical applications.
研究领域:
材料科学
·
生物医学工程
·
药理学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）