JOURNAL OF ALLOYS AND COMPOUNDS
·
2025
·
IF 6.3
Youquan Zhou,Xiaoyu Huang,Binyun Xia,Xiaohan Chen,Xinyue Jing,Ning Wang,Jinhua Li
Precise detection of ferric ions (Fe 3+ ) plays a critical role in maintaining biological homeostasis, ensuring industrial process quality control, and safeguarding ecological safety. Recently, various detection methods and sensors have been widely developed for measuring Fe 3+ , but the tradeoff between their performance and practical applications has not been achieved, such as high sensitivity, excellent specificity, simple structure and fabrication, low cost, and so on. In this study, an optical fiber SPR sensor was developed sensor for detecting Fe 3+ based on the multimode-coreless-multimode (MNM) structured optical fiber. The refractive index (RI) sensitivity of the MNM fiber coated with a 60 nm Au film modified with gold nanoparticles (AuNPs) reached 3440.45 nm/RIU. The organic groups functionalized carbon quantum dots (CQDs) were synthesized and immobilized onto the Au substrates for specifically trapping Fe 3+ , which will cause the variation of the effective RI around the fiber, thereby resulting in the SPR wavelength shift in the transmission spectrum. By recording the red shift of the SPR wavelength, the amount of Fe 3+ could be accurately quantified. Upon detection of Fe 3+ , the sensor was demonstrated with great linearity within a wide detection range of 10 −12 to 10 −2 M. The sensor’s sensitivity was obtained to be about 2.07 nm/lg (M) and its limit of detection (LOD) was calculated to be about 2.88 × 10 −13 M. It was also experimentally proved with excellent selectivity and stability, as well as the potential application in simulated real samples. The proposed sensing platform offered a simple configuration for Fe 3+ detection with excellent performance and had various potential practical applications such as health monitoring, disease diagnosis, dietary planning, medication treatment monitoring, environmental monitoring, etc.
研究领域:
生物医学工程
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分析化学
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环境科学
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产品关联
DOI
高影响因子
IEEE SENSORS JOURNAL
·
2024
·
IF 4.3
Lingling Li,Shen Yu,Chonglu Jing,Lihua Chen,Ai Zhou
In order to deal with the issue of low sensitivity to biomolecules concentrations in traditional optical fiber surface plasmon resonance (SPR) biosensors, a fiber SPR deoxyribonucleic acid (DNA) biosensor was developed, which is based on an amino-functionalized Zr-based metal–organic framework (MOF) (UIO-66-NH2)-modified heterogeneous core structure. Porous material UIO-66-NH2 facilitates electron transfer and amplifies the SPR effect, resulting in a heightened sensitivity for the detection of DNA hybridization. This can be attributed to the material’s advantageous characteristics, including a substantial specific surface area, an excellent water stability, and a pronounced affinity for probe-DNA (pDNA). The DNA biosensor presented in this study demonstrates enhanced sensitivity as a result of the covalent attachment of MOFs to pDNA, hence increasing the number of binding sites available for target DNA (tDNA). The optical fiber SPR biosensor, which has been modified with UIO-66-NH2, exhibits remarkable capabilities in detecting DNA concentrations ranging from 1 pM to 1 μM . It demonstrates a sensitivity of −7.72 nm/log ( μM ) and achieves a detection limit of 3 pM. In addition, the DNA biosensor has exceptional performance in terms of specificity and durability, rendering it a highly favorable option for utilization in several fields, such as drug delivery, protein identification, and environmental surveillance.
研究领域:
生物传感技术
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分子生物学
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产品关联
DOI
高影响因子
IEEE SENSORS JOURNAL
·
2024
·Vol. 24
·期 6
·7932-7938
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IF 4.3
Chunlan Liu,Ziqiang Zhang,Yabin Shao,Yong Wei,Puxi Ren,Yixiong Tang,Mingjun Cai,Zhihai Liu
Traditional methods for chromium ion detection have problems, such as slow detection speed, long detection cycle, and difficulty in on-site detection. Although fiber surface plasmon resonance (SPR) sensor has overcome these problems, their sensitivity cannot meet the detection requirements for chromium ion detection. Based on this, this article proposes a fiber SPR sensor based on a double helix loopback structure. By adjusting the parameters of the double helix structure, the light incidence angle in the sensing area was adjusted to improve the sensitivity. The symmetrical double helix structure increases the surface area of the sensing area and also enhances the structural strength of the sensor, and its optimal sensitivity is 6356 nm/RIU. After functionalizing the surface of the sensing probe, it is used for specific detection of chromium ion concentration, with a detection limit as low as 0.15 ng/mL, which achieves the rapid, real-time, and highly sensitive specific detection of chromium ions.
研究领域:
传感技术
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环境监测
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材料科学
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产品关联
DOI
高影响因子
SENSORS
·
2025
·Vol. 25
·期 5
·1630
·
IF 3.5
Qiang Xu,Huiting Yin,Mei Cui,Renliang Huang,Rongxin Su
A fiber-reinforced SPR sensor based on silver-nucleated gold-shell bimetallic nanoparticles and graphene oxide was developed and applied to human IgG detection. The refractive index (RI) sensitivity of the Ag@Au/GO fiber SPR sensor is as high as 4715.9 nm/RIU in the RI range of 1.333–1.365. Staphylococcus aureus protein A (SPA) can specifically recognize and bind to the fragment crystallizable (Fc) of the antibody; it facilitates the highly targeted immobilization of the antibody. SPA and rabbit anti-human IgG were immobilized on the surface of the Ag@Au/GO fiber SPR sensor for the detection of different concentrations of human IgG with a sensitivity of 0.53 nm/μg/mL and detection limits of 0.037 μg/mL. This biosensor based on the mixed structure of GO and Ag@Au combined the common advantages of the two materials. Therefore, our study provides a simple platform for biological analysis and has a good application prospect.
研究领域:
生物传感技术
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材料科学
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免疫学
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产品关联
DOI
PubMed
高影响因子
OPTICS EXPRESS
·
2023
·Vol. 31
·期 23
·38179-38190
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IF 3.8
Yong Wei,Chen Shi,Yonghui Zhang,Chunbiao Liu,Yixiong Tang,Puxi Ren,Chen Wang,Yu Zhang,Zhihai Liu
The current temperature-compensated fiber-optic surface plasmon resonance (SPR) biosensors are mainly open-ended outside the sensing structure, and there is a lack of temperature compensation schemes in fiber-optic microfluidic chips. In this paper, we proposed a temperature-compensated optical fiber SPR microfluidic sensor based on micro-nano 3D printing. Through the optical fiber micro-machining technology, the two sensing areas were designed on both sides of the same sensing fiber. The wavelength division multiplexing technology was used to collect the sensing light signals of the two sensing areas at the same time. The specific measurement of berberine and the detection of ambient temperature in the optical fiber SPR biological microfluidic channel were realized, and the temperature compensation matrix relationship was constructed, and then the temperature compensation was realized when measuring berberine biomolecules. Experiments have shown that the temperature sensitivity of the optical fiber SPR microfluidic sensor was 2.18 nm/°C, the sensitivity of the detection of berberine was 0.2646 nm/(µg/ml), the detection limit (LOD) was 0.38 µg/ml, and in a mixed solution showed an excellent specific detection impact.
研究领域:
生物医学工程
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光学传感
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微流控技术
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DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Chao Zhao,Jiayi Zhu,Xingye Ma,Jiaqi Sun,Ning Wang,Xi Chen,Xiaohan Chen,Yihao Wang,Chuanquan Wang,Xinyue Jing
Rapid and accurate pathogen detection is critical for optimizing clinical decision-making within precision medicine frameworks, specifically for identifying Staphylococcus aureus (S. aureus) in wound infections. Most of conventional detection methods suffer from procedural complexity, protracted analysis times, and insufficient sensitivity, thereby constraining their clinical deployment. In this work, an optical fiber surface plasmon resonance (SPR) sensor enhanced by Ti 3 C 2 T x MXene was developed for detecting S. aureus , biofunctionalized with goat anti-human immunoglobulin G (IgG). The optimal thickness of Ti 3 C 2 T x MXene layer, determined to be approximately 94 nm based on maximizing figure of merit (FOM) of 17.88 RIU −1 , yielded high sensitivity and low full width at half maximum (FWHM). By monitoring SPR wavelength shifts in the transmission spectra, the sensor was employed to detect S. aureus with a low limit of detection (LOD) of 1.14 CFU/mL and a high sensitivity of 3.063 nm/log (CFU/mL). It exhibited excellent linearity across the concentration range of 10 2 –10 8 CFU/mL, alongside high stability and selectivity. Validation using S. aureus -infected wound tissue from diabetic murine models exhibited a precision exceeding 97 %. This technology represents a promising avenue for developing next-generation, high-performance biosensing platforms with significant translational potential in precision medicine diagnostics.
研究领域:
生物传感器
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光学传感
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纳米材料
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生物医学诊断
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传染病检测
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产品关联
DOI
高影响因子
TALANTA
·
2022
·
IF 6.556
Like Li,Ya-nan Zhang,Wanlu Zheng,Xuegang Li,Yong Zhao
An optical fiber SPR biosensor based on multimode fiber (MMF)- hollow core fiber (HCF)-MMF is proposed and experimentally confirmed for in situ DNA hybridization analysis. In order to improve the sensitivity of DNA hybridization detection, a sandwich model based on gold nanoparticles (AuNPs) amplification is proposed. In this model, the probe DNA (pDNA) is first modified on the optical fiber sensing area by covalent bonding, and then the biotinylated target DNA (tDNA) is modified on the AuNPs by the high affinity between biotin and streptavidin. Finally, the tDNA on the surface of the AuNPs specifically hybridizes with the pDNA on the optical fiber to form a sandwich model. The near field coupling enhancement between AuNPs and gold film and the high mass ratio of AuNPs give high sensitivity to DNA hybridization detection. Experimental results show that the sandwich-type fiber SPR sensor has a log-linear response in the DNA concentration range of 1 pM–10 nM, and the sensitivity and detection limit are 4.04 nm/log(μM) and 1pM, respectively. This is 1.44 times more sensitive than that without sandwich assay. In addition, the DNA sensor has good specificity and stability, which foreshadows its great application potential in the fields of disease diagnosis, microbial detection and environmental science.
研究领域:
生物传感
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纳米技术
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光纤技术
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生物医学工程
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分析化学
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产品关联
DOI
PubMed
高影响因子
OPTICS EXPRESS
·
2023
·Vol. 31
·期 13
·21212-21224
·
IF 3.8
Zhuo Ren,Chunlan Liu,Yong Wei,Chunbiao Liu,Chen Shi,Xingkai Wang,Yixiong Tang,Rui Wang,Zhihai Liu
The Fiber SPR chip laboratory has become a popular choice in biochemical detection. To meet the needs of different kinds of analytes for the detection range and number of channels of the chip, we proposed a multi-mode SPR chip laboratory based on microstructure fiber in this paper. The chip laboratory was integrated with microfluidic devices made from PDMS and detection units made of bias three-core fiber and dumbbell fiber. By injecting light into different cores of a bias three-core fiber, different detection areas of dumbbell fiber can be selected, enabling the chip laboratory to enter high refractive index detection, multi-channel detection and other working modes. In the high refractive index detection mode, the chip can detect liquid samples with a refractive index range of 1.571-1.595. In multi-channel detection mode, the chip can achieve dual parameter detection of glucose and GHK-Cu, with sensitivities of 4.16 nm/(mg/mL) and 9.729 nm/(mg/mL), respectively. Additionally, the chip can switch to temperature compensation mode. The proposed multi working mode SPR chip laboratory, based on micro structured fiber, offers a new approach for the development of portable testing equipment that can detect multiple analytes and meet multiple requirements.
研究领域:
生物化学检测
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光学传感
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微流控技术
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生物医学工程
✓ 已验证
DOI
高影响因子
INFRARED PHYSICS & TECHNOLOGY
·
2025
·
IF 3.4
Lixia Li,Yurui Huang,Jiabin Zhao,Feiyou Liu,Ning Feng,Yufang Liu
Mercury ions (Hg 2+ ) are highly toxic heavy metal pollutants that pose significant risks to the environment and human health. In this paper, a fiber optic surface plasmon resonance (SPR) sensor is proposed for ultra-sensitive detection of Hg 2+ . The probe features Ag/ Ge 2 Sb 2 Te 5 (GST)/Ag composite film and metal–organic framework (MOF)-sensitized layer functionalized with probe DNA (pDNA). In the presence of Hg 2+ , pDNA interacts with target DNA (tDNA) carrying gold nanoparticles (AuNPs) in the solution through the T-Hg 2+ -T structure, immobilizing AuNPs on the sensing surface and inducing a spectral red shift. By combining GST’s high dielectric constant and MOF’s large surface area with strong pDNA affinity, the sensor achieves a maximum refractive index (RI) sensitivity of 11471 nm/RIU, detecting Hg 2+ as low as 10 pM. Furthermore, the deep learning model based on the residual neural network (ResNet) is employed to classify and recognize the SPR spectra corresponding to six distinct concentrations of Hg 2+ , achieving a training accuracy of 99.88 % and a test accuracy of 97.5 %. Therefore, ultra-sensitive fiber optic SPR sensor with deep learning delivers high-performance sensing while enabling rapid, precise, and sensitive quantification of Hg 2+ detection.
研究领域:
传感器
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环境监测
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光学传感
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纳米技术
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重金属检测
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机器学习
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产品关联
DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2021
·
IF 10.618
Zhuoyue Zhou,Zhao Yang,Li Xia,Houjin Zhang
Chiral analysis of amino acids (AAs) is of great importance in medical science due to the distinctive effect of AA isomers on human health. Although various chiral recognition techniques have been developed, the quantitative chiral recognition of low-level AA isomers remains challenging. Here, we combined the fiber optic SPR with an enzyme-substrate recognition mechanism to construct a direct-assay-type chiral AA biosensor. As a proof-of-concept attempt, a recently discovered Rasamsonia emersonii D-amino acid oxidase (ReDAAO) with a wide substrate spectrum and high stability was immobilized on the graphene oxide and gold nanorods composites (GO-AuNRs), using both EDC/NHS coupling and the gold-binding peptide (GBP) method. Such a biosensor can distinguish two AA isomers at the same concentration. It achieved specific detection of D-amino acids (D-AAs) with a linear range from 5x10 -4 mM to 30 mM. Furthermore, it showed good resistance to enantiomeric interference. When the percentage of D-AA increases in the isomer mixture, a good linear relationship between the D/(D + L)-AA ratio and SPR spectral shift was obtained. This unique combination of the enzyme , nanocomposite , and SPR taps into the rich reservoir of proteins for chiral receptors. It lays the foundation for protein-based chiral recognition of other clinically important small molecules in future biosensor designs.
研究领域:
生物传感器
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分析化学
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生物医学工程
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纳米技术
·
酶学
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产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2019
·
IF 6.393
Ling-Xin Kong,Yan-Xin Zhang,Wei-Gang Zhang,Yun-Shan Zhang,Tie-Yi Yan,Peng-Cheng Geng,Biao Wang
Lab-on-tip technology opens a new door for optical fiber surface plasmon resonance (SPR) sensors. In this paper, we first demonstrate an ultra-compact reflective SPR microtip probe on the flat fiber end in experiment, which has a length of tens of microns and a diameter of several microns. Simulations and experiments show that this new fiber SPR microtip probe coated with a nano-goldfilm has excellent refractive index (RI) sensing characteristic and great potential for biochemical detection at single cell level. Based on the high RI sensitivity, a bio-probe assembled with Chitosan/Polysodium Styrene Sulfonate (Cs/PSS) nano-polyelectrolyte film and the sheep anti-human IgG-HRP is prepared to recognize human IgG specifically. Due to the high surface sensitivity, the SPR microtip probe exhibits an ultra-low detection limit for human IgG. Due to the high bulk sensitivity and high thermo-optical coefficient (TOC) of polydimethylsiloxane (PDMS), a reference temperature probe based on SPR microtip is proposed, which is used to compensate for the temperature cross-sensitivity of the bio-probe. This new SPR microtip probe can be used not only in optical fiber sensor, but also in Tip-Enhanced Near-Field Raman Microscopy and Scanning Near-Field Optical Microscope.
研究领域:
光纤传感器
·
表面等离子体共振(SPR)技术
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生化传感
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纳米技术
·
显微镜
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）